1,721,079 research outputs found
Paul Hazard
No full textCabrini G. Paul Hazard. In: Bulletin de l'Association Guillaume Budé, n°1, juillet 1946. pp. 18-22
Paul Hazard
No full textCabrini G. Paul Hazard. In: Bulletin de l'Association Guillaume Budé, n°1, juillet 1946. pp. 18-22
Trimetilangelicina come correttore di CFTR in cellule dell'epielio bronchiale.
No full textL'invenzione si riferisce all'impiego di trimetilangelicina (TMA) e analoghi strutturali, per la preparazione di un medicamento per il trattamento della fibrosi cistica con l'obiettivo primario di correggere e potenziare il CFTR
Molecular basis of cystic fibrosis: from bench to bedside
No full textCystic fibrosis (CF), is an autosomal recessive disease affecting different organs. The lung disease, characterized by recurrent and chronic bacterial infection and inflammation since infancy, is the main cause of morbidity and precocious mortality of these individuals. The innovative therapies directed to repair the defective CF gene should account for the presence of more than 200 disease-causing mutations of the CF transmembrane conductance regulator (CFTR) gene. The review will recall the different experimental approaches in discovering CFTR protein targeted molecules, such as the high throughput screening on chemical libraries to discover correctors and potentiators of CFTR protein, dual-acting compounds, read-through molecules, splicing defects repairing tools, CFTR "amplifiers"
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Revealing the microRNA-transcription factors network in cystic fibrosis:from microRNA therapeutics to precision medicine (CF-miRNA-THER) FFC 7/2018
No full textThe project by Gambari et al. proposes to identify miRNAs that regulate (i) CFTR, (ii) transcription factors that regulate CFTR, and (iii) factors that enhance CFTR cell surface expression. Next, they will design and synthesize PNAs and PNA masks to inhibit these miRNAs and their interactions with specific mRNAs with important roles in CF, respectively; the effect of these PNA molecules and combinations thereof on gene expression and the secretome will be assessed. MiRNAs in various CF body fluids will be quantified. Overall the project aims to develop new therapeutics to enhance CFTR expression/function that may be used as adjunct therapies for people with CF
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Deepening into Silicone...Is It a Rubber Wall?
No full textRubber molding is a critical step in the investment casting process. Getting a mold to replicate the same master model over a long period and being highly reliable in terms of pattern integrity, detail reproduction and dimensional accuracy are necessary goals to get consistent results during casting. The introduction of silicone rubbers was a breakthrough in the traditional natural rubber molding technique, improving mold life cycle and, most of all, providing the opportunity to choose different material properties as a consequence of the pattern geometry.
In this study, different silicone rubbers with modified thermal behavior (and more specifically thermal conductivity) were produced and developed. In doing so, it was possible to get better performing silicone molds that were less affected by thermal aging. Improvements in thermal conductivity helped the solidification step of the injected wax and reduced shrinkage and defects.
Experimental work was required for fine tuning the vulcanization stage in order to get optimized mechanical properties
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