67,590 research outputs found
Dr. Lin Sun, CAU, March 2013
No full textThis video is a conversation with Dr. Lin Sun. Dr. Sun talks about an exhibit at the Woodruff Library titled "At The Boundary." Jordan Moore, AUC Woodruff Library, is the interviewer
Przedstawianie chińskiej filozofii zachodnim czytelnikom – Lin Yutang jako tłumacz międzykulturowy
No full textThe article reconstructs selected motifs in the philosophy of Lin Yutang, a twentieth-century Chinese thinker, translator and editor, especially popular in the West, undertaken, as it were, on the margins of his work to explain and popularize Chinese culture and philosophy in the West. Lin reflects on issues such as how to effectively and accurately explain a radically alien civilization to the Western-educated reader, in his or her own language, and who can appoint himself as the representative of Chinese culture at all? As a bilingual author, Lin very accurately shows the state of suspension between two cultures, characteristic of an intercultural interpreter who attempts to simultaneously move within two disproportionate, culturally determined conceptual schemes.W artykule rekonstruuję wybrane wątki refleksji Lin Yutanga, popularnego, zwłaszcza na Zachodzie, dwudziestowiecznego chińskiego myśliciela, tłumacza i redaktora, podejmowanej niejako na marginesie jego pracy na rzecz objaśniania i popularyzowania chińskiej kultury i filozofii na Zachodzie. Lin zastanawia się nad następującymi zagadnieniami, jak: W jaki sposób skutecznie, a jednocześnie trafnie opowiedzieć czytelnikowi wykształconemu w kulturze zachodniej, w jego własnym języku, o radykalnie obcej cywilizacji? Kto w ogóle może mianować samego siebie reprezentantem kultury chińskiej?
Jako autor dwujęzyczny Lin nader celnie ukazuje stan zawieszenia, stan bycia pomiędzy, charakterystyczny dla tłumacza międzykulturowego, który podejmuje próbę jednoczesnego poruszania się w obrębie dwóch niewspółmiernych, kulturowo zdeterminowanych schematów pojęciowych
Thermoresponsive Behaviors of Poly(oxypropylene)-amidoamine Functionalized Carbon Nanotubes
No full textDifferential roles of the microRNA let-7 in C. elegans tissue development
No full textThe organs and tissues of the human body comprise of an astonishing variety of cells as different in morphology and function as muscle cells and neurons. Amazingly, despite their different protein contents, they largely contain the identical genomic information. In order to understand the processes that enable this differentiation, we need to determine the underlying regulatory mechanisms. A very recent discovery in this context was the posttranscriptional regulation of gene expression by microRNAs (miRNAs). miRNAs are small RNA molecules that mediate translational repression and degradation of mRNA transcripts through partial complementarity to their 3’ untranslated region (UTR) . Among the first miRNAs to be identified, let-7 stands out for its high conservation in sequence and developmental functions in development throughout the animal kingdom. During my PhD, I studied the role of let-7 in Caenorhabditis elegans in the context of two distinct processes of tissue development, namely differentiation of the epidermis (called hypodermis), and morphogenesis of the vulva. The functions of the let-7 miRNA in formation of the adult cuticle have been extensively studied and are well understood. let-7 controls differentiation of specific, mitotically active epidermal cells by inducing cell cycle exit, fusion, and switch to an adult specific transcriptional program upon repression of targets such as lin-41, daf-12, hbl-1 and let-60/ras. I set out to identify novel interactors of let-7 in a genome-wide RNAi screen for suppression of the lethal let-7 bursting phenotype. Candidates were then verified using fluorescence-based reporter systems for onset of hypodermis differentiation and intensity of repression of a known target. Thereby, I was able to validate a whole set of novel members of the let-7 network, comprising genes downstream in the pathway as well as potential regulators of let-7 activity. Notably, both groups of repressors contain factors required for cell cycle progression and mitosis, which indicates an active crosstalk between let-7 and the cell-cycle machinery. In a second project, I explored the molecular basis for the prominent let-7 vulval bursting phenotype. Despite the absence of overproliferation or any other obvious phenotype in vulval morphogenesis, I was able to show that let-7 activity is required in the vulva, and that its major function in this context is repression of a single target, namely lin-41. Disruption of let-7 binding to lin-41 through modification of the let-7 complementary sites by CRISPR/Cas9 mediated genome editing suffices to trigger the bursting phenotype, proving that repression of a single target is the key function of the miRNA in this context. In summary, my work shows that while both differentiation of hypodermis as well as vulval integrity are mediated through repression of lin-41, the downstream effect of this regulation seem to differ, suggesting that let-7 can be wired to control distinct processes depending on the cellular context. With respect to the latest findings both in C. elegans as well as in mammals, it will be interesting to determine if this depends on differential molecular functions of LIN-41 in the two tissues
Spatial Chow-Lin Methods for Data Completion in Econometric Flow Models
No full textFlow data across regions can be modeled by spatial econometric models, see LeSage and Pace (2009). Recently, regional studies became interested in the aggregation and disaggregation of flow models, because trade data cannot be obtained at a disaggregated level but data are published on an aggregate level. Furthermore, missing data in disaggregated flow models occur quite often since detailed measurements are often not possible at all observation points in time and space. In this paper we develop classical and Bayesian methods to complete flow data. The Chow and Lin (1971) method was developed for completing disaggregated incomplete time series data. We will extend this method in a general framework to spatially correlated flow data using the cross-sectional Chow-Lin method of Polasek et al. (2009). The missing disaggregated data can be obtained either by feasible GLS prediction or by a Bayesian (posterior) predictive density.Missing values in spatial econometrics, MCMC, non-spatial Chow-Lin (CL) and spatial Chow-Lin (SCL) methods, spatial internal flow (SIF) models, origin and destination (OD) data
Anomalous temperature-driven magnetization switching in CoxNi1?x/Cu(1 0 0) binary alloy films
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IL-4 Modulates Lipopolysaccharide-mediated Nitric Oxide and IL-6 Release via Inhibition of the Extracelular Signal-regulated Kinases, p38 Mitogen-activated Protein Kinase and Protein Kinase C.
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