8,923 research outputs found
Competitive and Synergistic Interactions between Polymer Micelles, Drugs, and Cyclodextrins: The Importance of Drug Solubilization Locus
No full textPolymeric micelles, in particular PEO-PPO based Pluronic, have emerged as promising drug carriers, while cyclodextrins, cyclic oligosaccharides with an apolar cavity, have long been used for their capacity to form inclusion complexes with drugs. Dimethylated β-cyclodextrin (CD) has the capacity to fully breakup F127 Pluronic micelles, while this effect is substantially hindered if drugs are loaded within the micellar aggregates. Four drugs were studied at physiological temperature: lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salicylate (SAL); higher temperatures shift the equilibrium toward higher drug partitioning and lower drug/CD binding compared to 25 °C (Valero, M.; Dreiss, C. A. Growth, Shrinking, and Breaking of Pluronic Micelles in the Presence of Drugs and/or β-Cyclodextrin, a Study by Small-Angle Neutron Scattering and Fluorescence Spectroscopy. Langmuir 2010, 26, 10561−10571). The impact of drugs on micellar structure was characterized by small-angle neutron scattering (SANS), while their solubilization locus was revealed by 2D NOESY NMR. UV and fluorescence spectroscopy, Dynamic and Static Light Scattering were employed to measure a range of micellar properties and drug:CD interactions: binding constant, drug partitioning within the micelles, critical micellar concentration of the loaded micelles, aggregation number (Nagg). Critically, time-resolved SANS (TR-SANS) reveal that micellar breakup in the presence of drugs is substantially slower (100s of seconds) than for the free micelles (<100 ms) (Valero, M.; Grillo, I.; Dreiss, C. A. Rupture of Pluronic Micelles by Di-Methylated β-Cyclodextrin Is Not Due to Polypseudorotaxane Formation. J. Phys. Chem. B 2012, 116, 1273−1281). These results combined together give new insights into the mechanisms of protection of the drugs against CD-induced micellar breakup. The outcomes are practical guidelines to improve the design of drug delivery systems as well as an improved understanding of competitive assembly mechanisms leading to shape and function modulation
Selection Models for the Internal Quality of Fruit, based on Time Domain Laser Reflectance Spectroscopy
No full textTime domain laser reflectance spectroscopy (TRS) was applied for the first time to evaluate internal fruit quality. This technique, known in medicine-related knowledge areas, has not been used before in agricultural or food research. It allows the simultaneous measurement of two optical characteristics of the sample: light scattering inside the tissues and light absorption. Models to estimate non-destructively firmness, soluble solids and acid contents in tomato, apple, peach and nectarine were developed using sequential statistical techniques: principal component analysis, multiple stepwise linear regression, clustering and discriminant analysis. Consistent correlations were established between the two parameters measured with TRS, i.e. absorption and transport scattering coefficients, with chemical constituents (soluble solids and acids) and firmness, respectively. Classification models were created to sort fruits into three quality grades (‘low’, ‘medium’ and ‘high’), according to their firmness, soluble solids and acidity
Design Guidelines for a Quality Assessment System of Fresh Fruits in Fruit Centers and Hypermarkets
No full textRosana G. Moreira, Editor-in-Chief; Texas A&M UniversityThis is a Technical article from International Commission of Agricultural Engineering (CIGR, Commission Internationale du Genie Rural) E-Journal Volume 2 (2000): C. Valero and M. Ruiz-Altisent. Design Guidelines for a Quality Assessment System of Fresh Fruits in Fruit Centers and Hypermarkets
Thermodynamic and hydrological drivers of the subsurface thermal regime in Central Spain: open data and code
No full textQuality controlled temperature data at daily resolution at CTS, HRR, HYS, NVC, RSI and SGV and the most relevant codes for data processing used in:
García-Pereira, F., González-Rouco, J. F., Schmid, T., Melo-Aguilar, C, Vegas-Cañas, C., Steinert, N. J., Roldán-Gómez, P. J., Cuesta-Valero, F. J., García-García, A., Beltrami, H., and de Vrese, H.: "Thermodynamic and hydrological drivers of the subsurface thermal regime in Central Spain". Earth Surf. Dynam., submitted, 2023.
All data can be also freely obtained for research from the original data sources, GuMNet (https://www.ucm.es/gumnet/) and AEMET (https://www.aemet.es/en/datos_abiertos). Further details of the code are available upon request to the corresponding author (Félix García-Pereira, [email protected])
Sistemas con capacidad de cola limitada. M/M/c/K
No full textUna aproximación a los problemas de cola con capacidad limitada.https://polimedia.upv.es/visor/?id=b59c9e88-3ae8-8b4c-9121-d8ea9e0f35a3García Sabater, JP.; Maheut, JPD.; Valero Herrero, M. (2012). Sistemas con capacidad de cola limitada. M/M/c/K. https://riunet.upv.es/handle/10251/1645
Detection of internal quality in kiwi with time-domain diffuse reflectance spectroscopy
No full textTime-domain diffuse reflectance spectroscopy (TRS), a medical sensing technique, was used to evaluate internal kiwi fruit quality. The application of this pulsed laser spectroscopic technique was studied as a new, possible non-destructive, method to detect optically different quality parameters: firmness, sugar content, and acidity. The main difference with other spectroscopic techniques is that TRS estimates separately and at the same time absorbed light and scattering inside the sample, at each wavelength, allowing simultaneous estimations of firmness and chemical contents. Standard tests (flesh puncture, compression with ball, .Brix, total acidity, skin color) have been used as references to build estimative models, using a multivariate statistical approach. Classification functions of the fruits into three groups achieved a performance of 75% correctly classified fruits for firmness, 60% for sugar content, and 97% for acidity. Results demonstrate good potential for this technique to be used in the development of new sensors for non-destructive quality assessment
C. Valero-Garcés. Lingüística Forense. Contextos, Teoría y Práctica [Reseña de libro]
No full textReseña del libro: Carmen Valero-Garcés (ed.) 2018. Lingüística forense. contextos, teoría y práctica. Madrid: Edisofer, 172 páginas. ISBN: 978-84-15276-81-
A Computational Study of Stress Fiber-Focal Adhesion Dynamics Governing Cell Contractility
No full textWe apply a recently developed model of cytoskeletal force generation to study a cell’s intrinsic contractility, as well as its response to external loading. The model is based on a nonequilibrium thermodynamic treatment of the mechanochemistry governing force in the stress fiber-focal adhesion system. Our computational study suggests that the mechanical coupling between the stress fibers and focal adhesions leads to a complex, dynamic, mechanochemical response. We collect the results in response maps whose regimes are distinguished by the initial geometry of the stress fiber-focal adhesion system, and by the external load on the cell. The results from our model connect qualitatively with recent studies on the force response of smooth muscle cells on arrays of polymeric microposts
Application of Thermoeconomic Analysis to the Evaluation of Potential Improvement for Energy Resources Saving in Process Plants
No full textEstructura biposte 25m
No full text[ES] El TFG trata sobre el diseño estructural en acero de un cartel de publicidad de 25m de altura y una suprefice de 20x5m.[EN] The TFG deals with the structural design in steel of a 25m high public sign and a 20x5m surface.Bueno Valero, C. (2020). Estructura biposte 25m. Universitat Politècnica de València. https://riunet.upv.es/handle/10251/148740TFG
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