52 research outputs found
Tenascin-C is Strongly Expressed in the Anterior Vaginal Walls of Women with Pelvic Organ Prolapse
No full textObjectives: To compare the expression of tenascin in the anterior vaginal wall in women with pelvic organ prolapse and without pelvic organ prolapse (POP).
Method: This study was a cross sectional study. The study was conducted in RS Dr. Wahidin Sudirohusodo and other network hospitals of Obstetrics and Gynecology Department of Hasanuddin University, Makassar, from 1st January 2011 to 1st April 2012. This study assessed the expression of tenascin in 35 women with pelvic organ prolapse grade III and IV and the controls were 35 women without pelvic organ prolapse. Tenascin expression was assessed by immunohistochemical examination using tenascin antibody staining (mouse monoclonal antibody Novacastratenascin C, code NCLTenasC). Sampling was done by consecutive sampling. Data processed by the chi-square. The significance level used was 0.05. Result: The result of this research shows that with exception of history of bearing baby > 4000 gr weight (p=0.572); age, parity, menopausal status, and body mass index were significantly different between the group. This indicates that the variable does not affect the calculation of research data. While parity, menopausal status and body mass index (BMI), from an analysis of risk factors for POP were associated with increased intensity of tenascin is significant in postmenopausal status, and BMI > 25 (overweight) (p <0.05). Expression of tenascin in a sample of moderate (+ +) as many as 18 cases (51.5%) compared with controls expression of tenascin weaker (+) 25 cases (71.5%).
Conclusion: Expression of tenascin robust anterior vaginal wall in women with POP and weak women without POP.
Keywords: pelvic organ prolaps, risk factors, tenascin-
Child Abuse Negl
No full textBackground:Peer violence during childhood is associated with negative outcomes. Data are limited on its associated factors in sub-Saharan Africa.Objective:This study assesses the prevalence and factors associated with peer emotional and physical violence among children and adolescents aged 13\u201317years in C\uf4te d\u2019Ivoire.Participants and setting:Data from the 2018 C\uf4te d\u2019Ivoire Violence Against Children and Youth Survey (VACS) were used to examine peer emotional and physical violence victimization. VACS is a national cross-sectional household survey of females and males aged 13\u201324years.Methods:Data included physical, emotional, and sexual violence and socioeconomic, demographic, and relationship factors. We computed the adjusted odds ratios (AOR) and confidence interval (CI) for associated factors adjusted for food insecurity and rural or urban setting.Results:Thirty-one percent of females and 46.7 % of males experienced lifetime peer physical violence and 36.8 % of females and 40.2 % of males experienced peer emotional violence in the past 12 months. Witnessing violence in the home towards the mother (female AOR 1.2, CI 1.0\u20131.3); male AOR 1.4, CI 1.2\u20131.6) and witnessing violence in the home towards a sibling (female AOR 1.2, CI 1.1\u20131.3; male AOR 1.3, CI 1.12\u20131.4) increased the odds of ever experiencing peer physical violence. In males, not living with their biological mother (AOR 1.2, CI 1.0, 1.4) or biological father (AOR 1.2, CI 1.1\u20131.3) was associated with ever experiencing peer physical violence.Conclusion:Interventions for children and adolescents living without parents and programming focused on education and skills-building may help to reduce peer violence against children in C\uf4te d\u2019Ivoire.CC999999/ImCDC/Intramural CDC HHSUnited States/PEPFAR/PEPFARUnited States
Pop-Q Components Comparison among Multiparous and Nulliparous Women
No full textObjective: To compare the measurement of POP-Q components between multiparous and nulliparous women.
Method: This study is a cross-sectional research conducted in several hospitals in Makassar during the period of June to October 2012, with 270 women as the subjects. Subjects were divided into three groups: nulliparous, parity 1-2, and parity 3 (multiparous). We analyzed the mean POP-Q components results between 3 groups using t-test, analysis of prolapse based on POP-Q components measurement, and analysis of correlation between risk factors with prolapse was done using Chi-square test.
Result: There is a significant difference in POP-Q components measurement between multiparous and nulliparous women, consecutively for: Aa point -2.14 and -2.97 cm, Ba point -2.11 and -2.99 cm, C point -5.69 and -6.86 cm, gh 3.33 and 2.70 cm, pb 2.60 and 3.27 cm, TVL 8.65 and 9.06 cm, Ap point -2.35 and -2.93 cm, Bp point - 2.61 and -2.96 cm, D point -6.61 and -7.42 cm. In multiparous women, points Aa, Ba, C, D, Ap and Bp became more prolapsed, gh became longer, while pb and TVL became shorter.
Conclusion: The proportion of prolapse is higher in multiparous women with significant associations with age, body mass index, education level, and history of heavy physical work, delivering a large baby and use of hormonal contraceptives.
Keywords: multiparous women, nulliparous women, parity, POP-
Expression of Tenascin in the Uterosacral Ligament is Stronger in Women with Pelvic Organ Prolapse
No full textObjective: This study aimed to compare the expression of tenascin uterosacral ligament in women with and without pelvic organ prolapsen (POP).
Methods: The research was carried out in Dr. Wahidin Sudirohusodo Hospital and other educational hospitals of obstetrics and gynecology division UNHAS Faculty of Medicine, which began on January 1st, 2011 until April 2012. This study assessed the expression of tenascin in 35 women with POP levels III and IV, and the controls were 35 women without POP. Tenascin expression was assessed by immunohistochemical examination using tenascin antibody staining (mouse monoclonal antibody Novacastra tenascin C, code NCL-Tenas C). The research was carried out cross sectional. Sampling was done by consecutive sampling. Data processed by the chi-square. The significance level used was 0.05.
Results: The results showed that the characteristics of research subjects based on age, education, parity, labor history, history of big babies, not statistically significant. This indicates that the variable does not affect the calculation of the research data. While the characteristics of menopausal status and body mass index (BMI), from the analysis of risk factors for POP is associated significantly with a higher intensity of tenascin in post-menopausal status and BMI> 25 (overweight) (p <0.05). Expression of tenascin in the sample are significantly more powerful, the weak expression (8.6%), moderate (40.0%), and strong (51.4%) than without pelvic organ prolapsed. Expression of tenascin in the control, intensity tenascin weak (77.1%), moderate (20.0%), and strong (2.9%).
Conclusion: Expression of tenascin uterosacral ligament was stronger in women with POP compared with a weaker expression of tenascin in women without POP.
Keywords: pelvic organ prolapse, risk factors, tenasci
PENGARUHEKSTRAK DAUN LIDAH MERTUA (Sansevieria trifasciata laurentii) TERHADAP KADAR HEMOGLOBIN TIKUS PUITH JANTAN (Rattus norvegicus strain wistar) YANG DIINDUKSI TIMBAL PER-ORAL
No full textLogam berat timbal yang masuk kedalam tubuh dalam waktu singkat dan jumlah yang banyak dapat menyebabkan keracunan timbal sub-akut. Di sisi lain, daun Lidah Mertua (Sansevieria trifasciata laurentii) memiliki kandungan pregnane glycoside dan vitamin C sebagai antioksidan yang mampu mengikat logam berat timbal.Tujuan : Mengetahui pengaruh pemberian ekstrak daun Lidah Mertua (Sansevieria trifasciata laurentii) terhadap kadar hemoglobin pada tikus putih jantan (Rattus norvegicus starin wistar) yang telah diinduksi oleh timbal per-oral.Metode Penelitian : Penelitian ini menggunakan desain True Experimental Post Test Only Group Design. Penelitian ini dilakukan selama 15 hari dengan lima kelompok tikus, yaitu kelompok tanpa perlakuan (K-), kelompok yang diinduksi timbal saja (K+), kelompok P1, P2, dan P3 yang diberi ekstrak daun Lidah Mertua dengan dosis 8,3; 41; 83 mg/kgBB/hari, kemudian dilakukan induksi timbal menggunakan larutan timbal asetat dosis 15 mg/100gBB/hari. Pengambilan sampel darah tikus melalui ventrikel kemudian dilakukan uji kadar hemoglobin menggunakan metode cyanomethemoglobin.Hasil Penelitian dan Diskusi : Hasil penelitian 4 minggu didapatkan rerata hemoglobin kelompok K- adalah 12,98 g/dL, kelompok K+ adalah 13,18 g/dL, kelompok P1 adalah 12,16 g/dL, kelompok P2 adalah 12,64 g/dL, dan kelompok P3 adalah 12,96g/dL. Setelah diuji komparasi oneway ANOVA didapatkan nilai signifikansi 0,521 > p (0,05) yang berarti penelitian ini tidak terdapat perbedaan bermakna antara kadar hemoglobin pada seluruh kelompok.Kesimpulan : Pemberian ekstrak daun Lidah Mertua (Sansevieria trifasciata laurentii) tidak berpengaruh terhadap peningkatan kadar hemoglobin tikus putih jantan (Rattus norvegicus strain wistar) yang diinduksi timbal per-oral
“Beasts, Men and Gods”. A red purifying smoke offering (marsang) in Trika (Amdo)
No full textCet article traite d’un rituel rarement décrit, une offrande sanglante purificatrice (marsang) dédiée à Trike Yülha, le dieu du terroir d’un village de Amdo-Rebgong, et son évolution au cours des ans. Il soulève la question de l’identification de cette divinité locale avec deux divinités chinoises importantes : le dieu de la littérature Wenchang et celui de la guerre, Guandi. Utilisant des sources tibétaines et occidentales, l’auteure montre que cette identification daterait de l’époque des Qing et suggère qu’elle aurait peut-être permis de mieux faire accepter cette offrande si décriée dans le monde bouddhique.This article deals with a rarely described ritual, the red purifying smoke offering (marsang) and its evolution over the years. This bloody offering is dedicated to Trike Yülha, the territorial god of a village of Amdo-Rebgong. It raises the question of the identification of this local god with two important Chinese deities: the god of literature, Wenchang and that of war, Guandi. Using Tibetan and Western sources, the author shows that this identification dates back to the Qing period and suggests that it might have made an offering of this kind, that is so disparaged in the Buddhist world, more acceptable
A rare case of Takotsubo cardiomyopathy
No full textBACKGROUND: The recent advent of the cyclin-dependent kinase (CDK) 4/6 inhibitors has considerably evolved hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer treatment. Palbociclib, an orally administered pyridopyrimidine derivative, was the first CDK4/6 inhibitor to be introduced into daily clinical practice in combination with classic endocrine backbone, based on progression-free survival (PFS) benefit assessed in the pivotal PALOMA series of randomized clinical trials. Regarding its safety profile, neutropenia and leukopenia are the most common and well-defined adverse effects, while cardiac complications are rather scarce. CASE REPORT: We present the rare case of a middle-aged female patient with HR+/HER2-metastatic breast cancer, without prior exposure to cardiotoxic antineoplastic agents, who developed Takotsubo cardiomyopathy (TTC) in the context of systemic therapy with palbociclib plus letrozole combination. CONCLUSIONS: Pharmacovigilance and experimental studies are warranted to confirm any causative relationship and to explore the underlying pathophysiology, respectively. © 2024 Verduci Editore s.r.l. All rights reserved
The erotic imaginary of divine realization in Kabbalistic and Tantric metaphysics
No full textIn this paper I consider the way in which divinity is realized through an imaginary locus in the mystical thought of Jewish kabbalah and Hindu tantra. It demonstrates a reflective consciousness by the adept or master in understanding the place of God’s being, as a supernal and mundane reality. For the comparative assessment of these two distinctive approaches I shall use as a point of departure the interpretative strategies employed by Elliot Wolfson in his detailed work on Jewish mysticism. He argues that there is an androcentric bias embedded in the speculative outlook of medieval kabbalah, as he reads the texts through a psychoanalytic lens. In a similar way, I will argue that there is an androcentric bias to the speculations presented in medieval Shaiva tantra, in particular that division known as the Trika. Overall, my aim is to suggest some functional and perhaps structural similarities to the characterization of divinity in these two traditions, through brief analyses of the erotic understanding of the nature of the Godhead
Flamability evaluation of the fire-fighter underwear garment
No full textBakalářská práce se zaměřuje na metody měření hořlavosti a fyziologických vlastností nehořlavého materiálu s využitím pro hasiče. V první části jsou popsána vybraná funkční trika a jejich materiál, dále je popsán vnější oděv pro hasiče a zvolené vlastnosti. Ve druhé části je popsáno propojení a rozdíly mezi propustností vodních par, výparným odporem, vystavení sálavému teplu a zapálením. Pomocí vybraných přístrojů k měření. A následně jsou porovnány a vyhodnoceny jednotlivé materiály.The bachelor's work focuses on methods of measuring the flammability and physiological properties of non-flammable material using for firefighters. The first part describes the selected functional tricks and their material composition. As well as the external clothing for firefighters and the chosen properties. The second part describes the interconnection and differences between water vapour permeability, vapour resistance, exposure to radiant heat and ignition. Using selected instruments to measure. And subsequently, individual materials are compared and evaluated
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