1,720,965 research outputs found

    Diclofenac vs indomethacin in reducing postoperative inflammation : a randomized clinical trial

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    Purpose. To compare the efficacy and tolerability of diclofenac vs indomethacin eyedrops in reducing postoperative inflammation after phaco-extraction and IOL implantation. Methods. 100 patients undergoing phaco through a standard corneal tunnel procedure: 50 were given diclofenac 0.1% eyedrops, while 50 received indomethacin 0.1% eyedrops and were examined 1, 7 and 14 days after surgery. Postop inflammation was graded according to a dedicated scoring system that included evaluation of conjunctival hyperaemia, flare and cells count in the anterior chamber, corneal edema, and ciliary flush. Burning, stinging and blurred vision symptoms at drops instillation were recorded through a questionnaire. Other variables such as IOP, occurrence of surgical complications, duration of surgery, duration and intensity of phaco ultrasounds that might be related to study outcomes were also recorded. Results. Mean inflammatory scores were 4.00 (sd=1.05) and 5.32 (sd=1.64) at day 1, 1.14 (sd=0.45) and 1.61 (sd=0.51) at day 7, and 0.29 (sd=0.16) and 0.33 (sd=0.18) at day 14 for diclofenac and indomethacin respectively. After adjusting for factors related to surgery (i.e. duration of phacoemulsification, duration and intensity of ultrasounds, type of IOL, postop IOP etc.) the difference between the two groups failed to reach statistical significance. Tolerability was good both for diclofenac and indomethacin and no significant difference arised. Conclusions. Diclofenac and indomethacin seem to be both effective in reducing postop inflammation and provide a safe alternative to steroids for the management of the patients undergoing phacoemulsification

    Effectiveness of diclofenac eyedrops in reducing inflammation and the incidence of cystoid macular edema after cataract surgery

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    PURPOSE: To evaluate the effectiveness of diclofenac eyedrops in reducing inflammation and the incidence of angiographic cystoid macular edema (CME) after cataract surgery and intraocular lens (IOL) implantation. SETTING: Eye Clinic, Institute of Biomedical Sciences, San Paolo Hospital, Milan, Italy. METHODS: Eighty-eight patients having cataract extraction were enrolled in a randomized clinical trial: 42 were given diclofenac eyedrops and 46, placebo. Postoperative inflammation in both groups was graded for 6 months using a dedicated system. RESULTS: Eight patients (9%) had evidence of angiographic CME approximately 1 month after surgery: seven of these were in the placebo group (P = .039). This difference was not significant 3 and 6 months postoperatively. The signs of ocular inflammation were greater in the eyes receiving placebo; the difference was particularly evident up to 1 week after surgery. There was no significant difference in visual acuity between the two groups at any follow-up point, but the contrast sensitivity of the eyes that received diclofenac improved significantly at 10.5 cycles per degree 1 month postoperatively. CONCLUSION: Diclofenac eyedrops effectively reduced ocular inflammation and the occurrence of angiographic CME after cataract surgery

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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