118,089 research outputs found
[Supplementary Offense Report by J. C. Day #2]
No full textSupplementary offense report by J. C. Day. Day states that F. T. Alexander has the clothing worn by Lee Harvey Oswald when he was shot and that the clothing is locked up as evidence
[Supplementary Offense Report by J. C. Day #1]
No full textSupplementary offense report by J. C. Day. Day states that F. T. Alexander has the clothing worn by Lee Harvey Oswald when he was shot and that the clothing is locked up as evidence
[Supplementary Offense Report by J. C. Day #3]
No full textSupplementary offense report by J. C. Day, stating that F. T. Alexander of Dallas County Criminal Investigations Lab had locked up clothing worn by Lee Harvey Oswald as evidence
Tracking Virus-Specific CD4+ T Cells during and after Acute Hepatitis C Virus Infection
No full textBackground. CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving chronic hepatitis C CD4+ T cell helper responses appear to be absent or short-lived, using functional assays. Methodology/Prencipal Findings. Here we used a novel HLA-DR1 tetramer containing a highly targeted CD4+ T cell epitope from the hepatitis C virus non-structural protein 4 to track number and phenotype of hepatitis C virus specific CD4+ T cells in a cohort of seven HLA-DR1 positive patients with acute hepatitis C in comparison to patients with chronic or resolved hepatitis C. We observed peptide-specific T cells in all seven patients with acute hepatitis C regardless of outcome at frequencies up to 0.65% of CD4+ T cells. Among patients who transiently controlled virus replication we observed loss of function, and/or physical deletion of tetramer+ CD4+ T cells before viral recrudescence. In some patients with chronic hepatitis C very low numbers of tetramer+ cells were detectable in peripheral blood, compared to robust responses detected in spontaneous resolvers. Importantly we did not observe escape mutations in this key CD4+ T cell epitope in patients with evolving chronic hepatitis C. Conclusions/Significance. During acute hepatitis C a CD4+ T cell response against this epitope is readily induced in most, if not all, HLA-DR1 + patients. This antiviral T cell population becomes functionally impaired or is deleted early in the course of disease in those where viremia persists
Day, C T, NX118484
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/381073Surname: DAY. Given Name(s) or Initials: C T. Military Service Number or Last Known Location: NX118484. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 47296.195771
Item: [2016.0049.13366] "Day, C T, NX118484
Operational Tritium Inventories in the EU-DEMO Fuel Cycle
No full textThe European Demonstration Fusion Power Reactor (EU-DEMO) has to operate in a completely tritium self-sufficient mode after initial start-up, which includes producing excess tritium to allow the start-up of other reactors. The initial start-up inventory is mainly dictated by operational inventories in the fuel cycle (FC). Advances in FC technologies and immediate recycling of a large fraction of the torus exhaust gas in the direct internal recycling loop are expected to contribute greatly to an overall low operational inventory. The remainder of the torus exhaust gas, as well as tritium from the blankets, nevertheless requires treatment in the tritium plant in order to perform the necessary purification and isotope rebalancing. Here, the employed systems still feature significant operational inventories and predominantly require steady-state operation in order to maximize their performance. In this paper the operational tritium inventories in the major FC systems are reported based on the pre-concept FC design. Additionally, major dependencies of these inventories on key design drivers of the FC are discussed. It is predicted that the EU-DEMO FC will be able to operate with an overall tritium inventory of less than 2 kg
Environmental context and drug history modulate amphetamine-induced C-FOS mRNA expression in the basal ganglia, central extended amygdala and associated limbic forebrain
No full textThe context in which amphetamine is administered modulates its ability to induce both behavioral sensitization and immediate early gene expression. When given in a novel test environment amphetamine produces greater levels of c-fos and arc mRNA expression in many brain regions relative to when it is given in the home cage. The purpose of the current study was to determine if environment and drug history interact to influence amphetamine-induced c-fos mRNA expression. Rats with a unilateral 6-hydroxydopamine lesion were treated for 7 days with saline or 0.5 mg/kg of d-amphetamine (i.v.) in a distinct and relatively novel test environment (Novel), or in their home cage (Home). Following a 10-12-day withdrawal period, a challenge injection of either saline or 0.5 mg/kg d-amphetamine was administered. In situ hybridization histochemistry was used to examine c-fos mRNA expression in several regions of the basal ganglia, the central extended amygdala, and limbic forebrain. In most brain regions amphetamine given in the Novel environment produced greater c-fos mRNA expression than when given it was given at Home, and drug history had no effect on amphetamine-induced c-fos mRNA expression. However, within the subthalamic nucleus, substantia nigra reticulata, and central nucleus of the amygdala prior experience with amphetamine in the Novel but not Home environment enhanced the effect of an amphetamine challenge injection on c-fos mRNA expression. In contrast, there was a decrease in c-fos mRNA expression in amphetamine-pretreated animals, regardless of environmental context, in the ventral portion of the far caudal striatum. Reexposure to an environment previously paired with amphetamine produced a conditioned increase in c-fos mRNA expression in portions of the caudate-putamen, the subthalamic nucleus, the nucleus accumbens shell and a conditioned decrease in c-fos mRNA expression in the central nucleus of the amygdala. We conclude that environmental context and drug history interact to alter the basal ganglia and central extended amygdala circuitry engaged by subsequent exposure to amphetamine, or exposure to an environment previously paired with amphetamine. (C) 2003 IBRO. Published by Elsevier Science Ltd. All rights reserved
Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection
No full textThe aim of this project was to compare the breadth and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T cell phenotypes associated with latent infection and active disease. Ex vivo IFN? Elispots and proliferation assays were used to identify immunodominant ESAT6 and CFP10 15mer peptides targeted by CD8 T cells in LTBI and TB donors. A multiparameter flow cytometry panel was designed and optimized to assess turnover, susceptibility to apoptosis and terminal differentiation/senescence in CD8 T cells from TB and LTBI donors. Bcl-2, Ki67,CD95, CD57, CD127 and IFNγ were thus measured in each group
[Letter from Captain C. T. Edwards to Major T. N. Carswell - October 13, 1941]
No full textA letter written to Major T. N. Carswell, Commander, Tenth Battalion, Texas Defense Guard, from C. T. Edwards, Capt. CO D 34th BN Texas Defense Guard Inf Commanding, Brownfield, Texas, dated October 13, 1941. Edwards declines the invitation from Carswell for Company D of the 34th Battalion to attend the Armistice Day ceremonies in Abilene
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