192 research outputs found
Helmuth Schepp, 1894 - 1982, Plastiken, Zeichnungen : [eine Ausstellung in der Sparkasse Aachen, Zentrale Friedrich-Wilhelm-Platz, 19. April - 6. Mai 1994]
No full textAge rationing. Means of resource allocation in healthcare systems
No full textThe necessity of limiting resource in healthcare systems is becoming increasingly more evident. The population has requirements especially in the field of healthcare which are principally unlimited. However, there are only limited financial resources which can be used to satisfy the wishes of the population. For this reason rationing models are being discussed increasingly more often. One example of these models is called age rationing which means that defined services are only offered to patients up to a particular age. The aim of this article is to discuss the model of age rationing in the context of an optimized use of resources in the healthcare system
Autoantibodies in juvenile idiopathic arthritis: Glucose-6-phosphate isomerase is not a specific target
No full textObjective. Antibodies recognizing the ubiquitous cytosolic enzyme glucose-6-phosphate isomerase (GPI) cause arthritis in the K/BxN mouse model. Studies have shown that these antibodies are not specific for rheumatoid arthritis (RA) in humans. We evaluated GPI as a target of autoantibodies in juvenile idiopathic arthritis (JIA). Methods. We studied 324 serum and 48 synovial fluid (SF) samples from 103 patients with JIA, 36 with RA, and 8 with arthralgia and 11 controls. Anti-GPI antibodies were assessed by densitometrically evaluating immunoblots and ELISA using native and recombinant GPI. We determined the GPI activity of the soluble antigen in serum and SF. Results. Although several samples contained anti-GPI-IgG antibodies, this was not specific for JIA or its subgroups, or for RA. Other proteins in the GPI preparation were also frequently recognized by antibodies. Additionally, we observed increased GPI activity in patients with the systemic manifestation of JIA, but not in other patients. Neither anti-GPI concentrations nor GPI activity were associated with disease activity. Conclusion. In addition to the findings in RA, our results indicate that GPI is not a general target of autoantibodies in JIA
The Case for Reforming Euro Area Entry Criteria
No full textThe global economic and financial crisis has raised further concerns about the euro-entry criteria, in
addition to other factors, such as the effective tightening of the criteria due to the enlargement of the
EU from 12 to 27 members, the highly unfavourable property of business cycle dependence, the
internal inconsistency of the criteria due to the structural price level convergence of Central and
Eastern European countries, and the continuous violation of the criteria by euro-area members. The
interest rate criterion became a highly volatile measure. Many US metropolitan areas would fail to
qualify to be members of the US monetary union by applying the currently used inflation criterion to
the US. It is time to reform the criteria and to strengthen their economic rationale within the legal
framework of the EU treaty. A good solution would be to relate all criteria to the average of the euro
area and simultaneously to extend the compliance period from the currently considered one year to a longer period
A Pécsi Tudományegyetem gazdaságtudományi képzéseinek helyzetéről és fejlesztési lehetőségeiről
No full textAz előadás „A felsőoktatás és iparpolitika — helyzetfelmérés” c. konferencián hangzott el 2018. november 7-én. A rendezvényt a Magyar Statisztikai Társaság Statisztika-oktatási Szakosztálya, a Budapesti Corvinus Egyetem Statisztika Tanszéke és a Köz-Gazdaság c. folyóirat szerkesztősége szervezte
Tax morale and tax evasion: Social preferences and bounded rationality
No full textWe study a family of models of tax evasion, where a flat-rate tax finances only the provision of public goods, neglecting
audits and wage differences. We focus on the comparison of two modeling approaches. The first is based on optimizing
agents, who are endowed with social preferences, their utility being the sum of private consumption and moral utility. The second approach involves agents acting according to simple heuristics. We find that while we encounter the
traditionally shaped Laffer-curve in the optimizing model, the heuristics models exhibit (linearly) increasing Laffercurves. This difference is related to a peculiar type of behavior emerging within the heuristics based approach: a
number of agents lurk in a moral state of limbo, alternating between altruism and selfishness
Uncovering Yield Parity: A New Insight into the UIP Puzzle through the Stationarity of Long Maturity Forward Rates
No full textResults and models of this paper are based on a strikingly new empirical observation: long maturity forward rates between bilateral currency pairs of the US, Germany, UK, and Switzerland are stationary. Based on this result, we suggest a new explanation for the UIP-puzzle maintaining rational expectations and risk neutrality. The model builds on the interaction of foreign exchange and fixed income markets. Ex ante short run and long run UIP and the EHTS is assumed. We show that ex post shocks to the term structure could explain the behavior of the nominal exchange rate including its volatility and the failure of ex post short UIP regressions. We present evidence on ex post validity of long run UIP and strikingly new evidence on the stationarity of the long forward exchange rates of major currencies. We set up, calibrate and simulate a stylized model that well captures the observed properties of spot exchange rates and UIP regressions of major currencies. We define the notion of yield parity and test its empirical performance for monthly series of major currencies with favorable resultsEHTS, forward discount bias, stationarity of long maturity forward rates, UIP, yield parity
Effects of prostaglandins on gastrin release from canine antral mucosal cells in primary culture
No full textEvidence in vivo indicates that endogenous and exogenous prostaglandins can alter gastrin secretion. We have used primary cultures containing canine antral G-cells to study the cellular actions of prostaglandins on gastrin secretion, comparing the effects of prostaglandin E2 (PGE2) and its synthetic analogue enprostil. Enprostil (10(-10)-10(-6) M) inhibited gastrin secretion in response to bombesin, carbachol, and forskolin, the latter a receptor-independent activator of adenylate cyclase. This inhibition by enprostil was reversed by treatment with pertussis toxin (200 ng/ml, 8 h). However, enprostil did not inhibit the postreceptor stimuli 8-bromoadenosine 3',5'-cyclic monophosphate (10(-3) M), calcium ionophore A-23187 (10(-7) M), or 4 beta-phorbol 12-myristate 13-acetate (10(-8) M). In contrast, whereas PGE2 inhibited forskolin-stimulated gastrin release, PGE2 did not inhibit the response to carbachol or bombesin in control cultures. However, in pertussis toxin-treated cultures, PGE2 inhibition was reversed and, in contrast, the responses to bombesin, carbachol, and possibly forskolin were augmented. Indomethacin at a dose of 10(-5) M did not alter basal or bombesin-stimulated gastrin secretion. However, the somatostatin antibody CURE-S6 enhanced the response to forskolin and enhanced inhibition by PGE2, suggesting that endogenous somatostatin produced an inhibitory tone in these cultures and excluding the possibility that PGE2 acted via release of endogenous somatostatin. Our data suggest that in cultured antral cells gastrin release is regulated by inhibitory and stimulatory prostaglandin mechanisms.(ABSTRACT TRUNCATED AT 250 WORDS)LR: 20061115; PUBM: Print; JID: 0370511; 0 (Adenylate Cyclase Toxin); 0 (Gastrins); 0 (Prostaglandins); 0 (Virulence Factors, Bordetella); 363-24-6 (Dinoprostone); 73121-56-9 (Enprostil); EC 2.4.2.31 (Pertussis Toxin); ppublishSource type: Electronic(1
A kötvény- és devizapiacok kölcsönhatásának szerepe a rugalmas devizaárfolyamok alakulásának értelmezésében = The role of the interaction between foreign exchange and fixed income markets in understanding exchange rate behavior
No full textKutatásaink három főbb vonalon hoztak eredményeket: 1) A devizapiac és a hozamgörbe várakozási hipotéziseinek együttes feltevéséből kiinduló elméleti megközelítésünkben rámutattunk, hogy a kötvény- és devizapiacok sokkjai között szimultán összefüggés valósul meg. Szimulációs vizsgálataink szerint a hozamgörbe hosszú végének sokkjai a gyakorlatban megfigyelt jelenségekkel összhangban transzformálódhatnak a devizaárfolyamok mozgásaiba. 2) Elméleti megközelítésünkkel összefüggésben felfedeztünk egy eddig nem vizsgált empirikus tényt: a vezető devizák határidős devizaárfolyamainak perzisztenciája a lejárat növelésével csökken. Hosszú (5-10 éves) lejáratoknál a stacionaritás lehetőségét sem vetik el a formális tesztek. 3) A hosszú lejáratú határidős devizaárfolyamok stacionaritását vélelmező hibakorrekciós modellek lehetővé teszik az azonnali árfolyamok mintán kívüli előrejelzését: a) 20 éves mintán kívüli előrejelzési időszakot vizsgáltunk havi frekvencián; b) Az amerikai dollár 9 legfontosabb árfolyamát vizsgáltuk (a devizapiac 75%-a!); c) A mintán kívüli előrejelzések szignifikanciáját bootstrap-teszttel ellenőriztük; d) Valamennyi esetben szignifkánsan jobb mintán kívüli előrejelzést adtunk, mint a benchmark martingál hipotézis (véletlen bolyongás), ill. az alternatív modellek. e) Bár eredményeink a világgazdasági válság 2008 őszi kirobbanását követően minimálisan romlottak, alapvető következtetéseink továbbra sem módosultak. | Our research has reached delivered new findings in the following three main topics: 1) Our model combining the expectation hypotheses of the FOREX market and the term structure of interest rates has revealed the interconnection of shocks to FOREX and fixed income markets. We showed that shocks to the term structure could explain the behaviour of the nominal exchange rate including its volatility and the failure of regressions to provide evidence in favour of the hypothesis of short horizon uncovered interest rate parity. 2) In connection to our theoretical model, we have discovered a strikingly new empirical observation: long maturity (e.g. 5/10 years) forward rates between major currencies are less persistent than spot exchanges rate and even many of them are found to be stationary by a large number of unit root and stationarity tests. 3) Our error correction models assuming that long-maturity forward rates are stationary provide extraordinary forecasting results. These models outperform the random walk (and many alternative models) in out-of-sample forecasting at forecasting horizons mostly above one year, for US dollar exchange rates against nine industrial countries? currencies, using a 20-year long period (1990-2009) for evaluating out-of-sample forecasts. The improvement in forecast accuracy of our models is economically significant for most of the exchange rate series and statistically significant according to a bootstrap test
Endoskopischer Verschluss einer iatrogenen Perforation bei der endoskopischen Divertikuloösophagotomie eines Zenker-Divertikel mittels Clips
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