44 research outputs found
Fernand Pouillon. Costruzione, Città, Paesaggio
No full textLa Mostra Fernand Pouillon. Costruzione, città, paesaggio costituisce un’occasione di riflessione e confronto sull’opera di un maestro dell’architettura del Novecento che appartiene, con altri, a un’altra storia spesso troppo poco raccontata. La lunga carriera e il gran numero di edifici realizzati da Pouillon in diversi paesi del Mediterraneo, sono prova di una ricerca appassionata e di grande valore che spazia dalla scala urbana a quella della costruzione. La selezione dei lavori, a cura degli ideatori dell’iniziativa Giulio Barazzetta, Renato Capozzi e Catherine Sayen - allestiti in mostra da Francesca Patrono, Mirko Russo e Claudia Sansò presso l’Ambulacro della Biblioteca di Palazzo Gravina a Napoli - rappresenta uno sguardo attento su questa significativa produzione, concentrandosi accuratamente su quattro opere ritenute ‘paradigmatiche’ e individuando, per ciascuna di esse, un’altra che ne rappresentasse una declinazione secondo un principio di continuità di temi affrontati e soluzioni proposte. I grandi complessi urbani costruiti in Francia e Algeria indicano la vocazione di queste architetture a costituire pezzi della città moderna che siano in grado di interpretare le tracce dei contesti. Si rinvengono i temi della complessità tipo-morfologica ma anche della prefabbricazione e della razionalizzazione del processo edilizio, mediando tra la tradizione e una industrializzazione finalizzata all’edilizia di massa
Mutations of Histidine 13 to Arginine and Arginine 5 to Glycine Are Responsible for Different Coordination Sites of Zinc(II) to Human and Murine Peptides
No full textBecause mice and rats do not naturally develop Alzheimer's disease, genetically modified animals are required to study this pathology. This striking difference in terms of disease onset could be due to three alterations in the murine sequence (R5G, Y10F and H13R) of the amyloid-β peptide with respect to the human counterpart. Whether the metal-ion binding properties of the murine peptide are at the origin of such different amyloidogenicity of the two peptides is still an open question. Herein, the main zinc binding site to the murine amyloid-β at physiological pH has been determined through the combination of several spectroscopic and analytical methods applied to a series of six peptides with one or two of the key mutations. These results have been compared with the zinc binding site encountered in the human peptide. A coordination mechanism that demonstrates the importance of the H13R and R5G mutations in the different zinc environments present in the murine and human peptides is proposed. The nature of the minor zinc species present at physiological pH is also suggested for both peptides. Finally, the biological relevance and fallouts of the differences determined in zinc binding to human versus murine amyloid-β are also discussed
The RNA Processing Enzyme Polynucleotide Phosphorylase Negatively Controls Biofilm Formation by Repressing Poly-N-Acetylglucosamine (PNAG) Production in Escherichia coli C
No full textLink between Affinity and Cu(II) Binding Sites to Amyloid-β Peptides Evaluated by a New Water-Soluble UV-Visible Ratiometric Dye with a Moderate Cu(II) Affinity
No full textBeing able to easily determine the Cu(II) affinity for biomolecules of moderate affinity is important. Such biomolecules include amyloidogenic peptides, such as the well-known amyloid-β peptide involved in Alzheimer's disease. Here, we report the synthesis of a new water-soluble ratiometric Cu(II) dye with a moderate affinity (109 M-1 at pH 7.1) and the characterizations of the Cu(II) corresponding complex by X-ray crystallography, EPR, and XAS spectroscopic methods. UV-vis competition was performed on the Aβ peptide as well as on a wide series of modified peptides, leading to an affinity value of 1.6 × 109 M-1 at pH 7.1 for the Aβ peptide and to a coordination model for the Cu(II) site within the Aβ peptide that agrees with the one mostly accepted currently
The Emperor and the Secretary: What the Corpus Juris Civilis and The Secret History of Procopius Reveal about Imperial Ideology in the Age of Justinian
No full textM2ex project. Metformin and Lamotrigine sorption on a digestate amended soil in presence of trace metal contamination [Dataset]
No full textExploiting metal-microbe applications to expand the circular economy (M2ex) GA no 861088, 12 pages, 3 tables, 7 images.The antidiabetic drug metformin and antiepileptic drug lamotrigine are contaminants of emerging concern that have been detected in biowaste-derived amendments and in the environment, and their fate must be carefully studied. This work aimed to evaluate their sorption behaviour on soil upon digestate application. Experiments were conducted on soil and digestate-amended soil as a function of time to study kinetic processes, and at equilibrium also regarding the influence of trace metals (Pb, Ni, Cr, Co, Cu, Zn) at ratio pharmaceutical/metal 1/1, 1/10, and 1/100. Pharmaceutical desorption experiments were also conducted to assess their potential mobility to groundwater. Results revealed that digestate amendment increased metformin and lamotrigine adsorbed amounts by 210% and 240%, respectively, increasing organic matter content. Metformin adsorption kinetics were best described by Langmuir model and those of lamotrigine by Elovich and intraparticle diffusion models. Trace metals did not significantly affect the adsorption of metformin in amended soil while significantly decreased that of lamotrigine by 12–39%, with exception for Cu2+ that increased both pharmaceuticals adsorbed amounts by 5 – 8%. This study highlighted the influence of digestate amendment on pharmaceutical adsorption and fate in soil, which must be considered in the circular economy scenario of waste-to-resource.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 861088.Peer reviewe
Modern Art and Modern Movement: Images of Dance in American Art, c. 1900-1950
No full text"Modern Art and Modern Movement: Images of Dance in American Art, c. 1900-1950," considers the intersections and interrelations of two of the major artistic developments of the twentieth century, modern dance and modern art, through an examination of the paintings, sculptures, photographs, and drawings that engage simultaneously with these developing art forms. The first chapter introduces cultural attitudes toward dance performances in the United States at the beginning of the twentieth century with an examination of Everett Shinn's, Louis Kronberg's, and Malvina Hoffman's depictions of European ballet dancers, such as Russian Anna Pavlova. Chapter two discusses images of Isadora Duncan, the mother of modern dance, created by Abraham Walkowitz, John Sloan, Robert Henri, and Arthur B. Davies. Constructs of "Orientalism" and "the Other" in images of dance created by Paul Manship, Gaston Lachaise, and Alexander Calder, artists who felt the influence of the Indian dances of Ruth St. Denis and Ted Shawn and l'art n�_��gre fervor surrounding Josephine Baker, respectively, make up chapter three. Chapter four examines the of art of H. Lyman Sayen, Stanton Macdonald-Wright, Morgan Russell, and Franz Kline who were inspired by the Ballets Russes's lavish productions and consequently sought to convey the relationship between dance, costume, music, and set. Chapter five discusses depictions of the prolific choreographer and modern dancer Martha Graham by photographer Barbara Morgan, painter Paul Meltsner, and sculptors David Smith and Louise Nevelson. The concluding chapter examines the gestural abstractions of Jackson Pollock and the mobiles of Alexander Calder; artists who were not responding to individual dancers or specific dance styles, but whose involvement with dance was at a much more basic level. Pollock and Calder incorporated the fundamental element of dance, movement through time, into their works of art
Metformin and lamotrigine sorption on a digestate amended soil in presence of trace metal contamination
No full text12 Páginas.-- 7 Figuras.-- 3 Tablas.
Este trabajo es financiado por el proyecto M2ex “Exploiting metal-microbe applications to expand the circular economy”, cuyo Investigador Principal es el Dr. Fernando G. Fermoso (Instituto de la Grasa-CSIC)The antidiabetic drug metformin and antiepileptic drug lamotrigine are contaminants of emerging concern that have been detected in biowaste-derived amendments and in the environment, and their fate must be carefully studied. This work aimed to evaluate their sorption behaviour on soil upon digestate application. Experiments were conducted on soil and digestate-amended soil as a function of time to study kinetic processes, and at equilibrium also regarding the influence of trace metals (Pb, Ni, Cr, Co, Cu, Zn) at ratio pharmaceutical/metal 1/1, 1/10, and 1/100. Pharmaceutical desorption experiments were also conducted to assess their potential mobility to groundwater. Results revealed that digestate amendment increased metformin and lamotrigine adsorbed amounts by 210% and 240%, respectively, increasing organic matter content. Metformin adsorption kinetics were best described by Langmuir model and those of lamotrigine by Elovich and intraparticle diffusion models. Trace metals did not significantly affect the adsorption of metformin in amended soil while significantly decreased that of lamotrigine by 12-39%, with exception for Cu2+ that increased both pharmaceuticals adsorbed amounts by 5 - 8%. This study highlighted the influence of digestate amendment on pharmaceutical adsorption and fate in soil, which must be considered in the circular economy scenario of waste-to-resource.This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 861088.Peer reviewe
