319,859 research outputs found
Concilium Nicenum, Synodi Nicenae ... anno a Christo nato DCC.LXXXI ... habitae : actiones omnes contra iconoclastas & iconomachos ... in quibus imaginum usus ut pius & sanctorum suffragia, ut necessaria asseruntur
No full textCCBE S. XVI, C, 2503
Colofón
Sign.: a6, A-Q6A Res. 04/2/1
Navigation et commerce dans le delta du Rhône: l’épave Arles-Rhône 14 (IIIe s. ap. J.-C.)
No full textCondiscipuli Sumus
No full textThis chapter addresses the place of horizontal learning in monastic
culture. Firstly, it focuses on the relation between theoretical instances
of horizontal learning and the evidence for horizontal learning practices
in monastic everyday life. On the basis of this, it proposes a reflection
on the extent to which horizontal learning can be associated with the
monastic world in comparison to other contexts, first and foremost the
world of secular clerics and canon regulars. While there can be no doubt
that horizontal learning is not unique to the monastic world, an evaluation
of the complex balance between horizontal learning and vertical learning
must always consider that much depends on the individual author, his or
her social and religious status, the kind of community, and the specific
contents and contexts of learning
Experimental warming and long-term vegetation dynamics in an alpine heathland
No full textHigh mountain ecosystems are vulnerable to the effects of climate warming and Australia’s alpine vegetation has been identified as particularly vulnerable. Between 2004 and 2010, we monitored vegetation changes in a warming experiment within alpine open grassy-heathland on the Bogong High Plains, Victoria, Australia. The study was part of the International Tundra Experiment (ITEX Network) and used open-topped chambers (OTC) to raise ambient growing-season temperatures by ~1°C at two sites. We assessed the effects of experimental warming on vegetation composition, diversity and cover using ordination, linear models and hierarchical partitioning. Results were compared with vegetation changes at four long-term (non-ITEX) monitoring sites in similar vegetation sampled from 1979 to 2010. The warming experiment coincided with the driest 13-year period (1996–2009) since the late 1880s. At the ITEX sites, between 2004 and 2010, graminoid cover decreased by 25%, whereas forb and shrub cover increased by 9% and 20%, respectively. Mean canopy height increased from 7 cm to 10 cm and diversity increased as a result of changes in relative abundance, rather than an influx of new species. These vegetation changes were similar to those at the four non-ITEX sites for the same period and well within the range of changes observed over the 31-year sampling period. Changes at the non-ITEX sites were correlated with a decrease in annual precipitation, increase in mean minimum temperatures during spring and increase in mean maximum temperature during autumn. Vegetation changes induced by the warming experiment were small rather than transformational and broadly similar to changes at the long-term monitoring sites. This suggests that Australian alpine vegetation has a degree of resilience to climate change in the short to medium term (20–30 years). In the long term (>30 years), drought may be as important a determinant of environmental change in alpine vegetation as rising temperatures. Long-term vegetation and climate data are invaluable in interpreting results from short-term (≤10 years) experiments
EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing: a NICE medical technology guidance
No full textOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.This article has been made available through the Brunel Open Access Publishing Fund.A routine part of the process for developing National Institute for Health and Care Excellence (NICE) medical technologies guidance is a submission of clinical and economic evidence by the technology manufacturer. The Birmingham and Brunel Consortium External Assessment Centre (EAC; a consortium of the University of Birmingham and Brunel University) independently appraised the submission on the EXOGEN bone healing system for long bone fractures with non-union or delayed healing. This article is an overview of the original evidence submitted, the EAC’s findings, and the final NICE guidance issued.The Birmingham and Brunel Consortium is funded by NICE to act as an External Assessment Centre for the Medical Technologies Evaluation Programme
A simple disc wind model for broad absorption line quasars
No full textApproximately 20 per cent of quasi-stellar objects (QSOs) exhibit broad, blue-shifted absorption lines in their ultraviolet spectra. Such features provide clear evidence for significant outflows from these systems, most likely in the form of accretion disc winds. These winds may represent the ‘quasar’ mode of feedback that is often invoked in galaxy formation/evolution models, and they are also key to unification scenarios for active galactic nuclei (AGN) and QSOs. To test these ideas, we construct a simple benchmark model of an equatorial, biconical accretion disc wind in a QSO and use a Monte Carlo ionization/radiative transfer code to calculate the ultraviolet spectra as a function of viewing angle. We find that for plausible outflow parameters, sightlines looking directly into the wind cone do produce broad, blue-shifted absorption features in the transitions typically seen in broad absorption line (BAL) QSOs. However, our benchmark model is intrinsically X-ray weak in order to prevent overionization of the outflow, and the wind does not yet produce collisionally excited line emission at the level observed in non-BAL QSOs. As a first step towards addressing these shortcomings, we discuss the sensitivity of our results to changes in the assumed X-ray luminosity and mass-loss rate, Ṁwind. In the context of our adopted geometry, Ṁwind ∼ Ṁacc is required in order to produce significant BAL features. The kinetic luminosity and momentum carried by such outflows would be sufficient to provide significant feedback
Modeling the spectral signatures of accretion disk winds: a new Monte Carlo approach
No full textBipolar outflows are present in many disk-accreting astrophysical systems. In disk-accreting cataclysmic variables (CVs), these outflows are responsible for most of the strong features in the ultraviolet spectra of these systems. However, there have been few attempts to model these features quantitatively. Here we describe a new, hybrid Monte Carlo/Sobolev code, which allows us to synthesize the complete spectrum of a disk-dominated, mass-losing CV. The line profiles that we calculate for C IV resemble those calculated by previous workers when an identical geometry is assumed. However, our synthetic spectra exhibit not only the well-known resonance lines of O VI, N V, Si IV, and C IV but, with an appropriate choice of mass-loss rate and wind geometry, also many lines originating from excited lower states. Many of these lines have already been seen in the far-ultraviolet spectra of CVs obtained with the Hopkins Ultraviolet Telescope, the Far Ultraviolet Spectroscopic Explorer, and the Hubble Space Telescope. In order to illustrate the degree to which we are currently able to reproduce observed spectra, we finally present a preliminary fit to the Hopkins Ultraviolet Telescope spectrum of the dwarf nova Z Cam in outburst
Optimization of Long-Haul C+L+S Systems by Means of a Closed Form EGN Model
No full textWe investigate C+L+S long-haul systems using a closed-form GN/EGN non-linearity model. We perform accurate launch power and Raman pump optimization. We show a potential 4x throughput increase over legacy C-band systems in 1000 km links, using moderate S-only Raman amplification. We simultaneously achieve extra-flat GSNR, within ±0.5 dB across the whole C+L+S spectrum
Ribosomes as a nexus between translation and cancer progression: Focus on ribosomal Receptor for Activated C Kinase 1 (RACK1) in breast cancer
No full textRibosomes coordinate spatiotemporal control of gene expression, contributing to the acquisition and maintenance of cancer phenotype. The link between ribosomes and cancer is found in the roles of individual ribosomal proteins in tumorigenesis and cancer progression, including the ribosomal protein, receptor for activated C kinase 1 (RACK1). RACK1 regulates cancer cell invasion and is localized in spreading initiation centres, structural adhesion complexes containing RNA binding proteins and poly-adenylated mRNAs that suggest a local translation process. As RACK1 is a ribosomal protein directly involved in translation and in breast cancer progression, we propose a new molecular mechanism for breast cancer cell migration and invasion, which considers the molecular differences between epithelial and mesenchymal cell profiles in order to characterize and provide novel targets for therapeutic strategies. Hence, we provide an analysis on how ribosomes translate cancer progression with a final focus on the ribosomal protein RACK1 in breast cancer
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
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