11,352 research outputs found
A novel variant in CMAH is associated with blood type AB in Ragdoll cats
No full textCitation: Gandolfi, B., Grahn, R. A., Gustafson, N. A., Proverbio, D., Spada, E., Adhikari, B., . . . Helps, C. R. (2016). A novel variant in CMAH is associated with blood type AB in Ragdoll cats. Plos One, 11(5). doi:10.1371/journal.pone.0154973The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase is associated with the production of sialic acids on cat red blood cells. The cat has one major blood group with three serotypes; the most common blood type A being dominant to type B. A third rare blood type is known as AB and has an unclear mode of inheritance. Cat blood type antigens are defined, with N-glycolylneuraminic acid being associated with type A and N-acetylneuraminic acid with type B. Blood type AB is serologically characterized by agglutination using typing reagents directed against both A and B epitopes. While a genetic characterization of blood type B has been achieved, the rare type AB serotype remains genetically uncharacterized. A genome-wide association study in Ragdoll cats (22 cases and 15 controls) detected a significant association between blood type AB and SNPs on cat chromosome B2, with the most highly associated SNP being at position 4,487,432 near the candidate gene cytidine monophospho-N-acetylneuraminic acid hydroxylase. A novel variant, c.364C>T, was identified that is highly associated with blood type AB in Ragdoll cats and, to a lesser degree, with type AB in random bred cats. The newly identified variant is probably linked with blood type AB in Ragdoll cats, and is associated with the expression of both antigens (N-glycolylneuraminic acid and N-acetylneuraminic acid) on the red blood cell membrane. Other variants, not identified by this work, are likely to be associated with blood type AB in other breeds of cat. © 2016 Gandolfi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Narrative support for technical documents: Formalising Rhetorical Structure Theory
No full textBusiness Process Re-engineering (BPR) is an area that requires a lot of technical documents and an important feature of a well-written document is a coherent narrative. Even though computer software has helped authors in many other aspects of writing, support for document narratives is almost non-existent. Therefore, we introduce CANS (Computer-Aided Narrative Support), a tool that uses Rhetorical Structure Theory to enhance the narrative of a document. From this narrative, the tool generates questions to prompt the author for the content of the document. CANS also allows the author to explore alternative narratives for a document. A catalogue of predefined narrative structures for popular types of documents is provided too. Our tool is still in its rudimentary stages but sufficiently complete to be demonstrated
Educazione sessuale come educazione morale
No full textIl saggio introduce e analizza il dibattito che vede tra i protagonisti il ginecologo Doléris e il sociologo Durkheim permettendo di osservare in che termini e con quali osservanze, alle porte della Grande Guerra, la sessualità entrava nei dibattiti, come anche nelle scuole e negli istituti; dall’altro lato aiuta nella comprensione di una figura poliedrica, eclettica, quella del padre putativo del funzionalismo organicista, tassello fondamentale per l’intera storia della sociologia, Émile Durkheim. Ancora oggi la figura del sociologo è piuttosto dibattuta e si muove all’interno di un paradosso che lo vede sia come un progressista che come un conservatore.The essay introduces and analyzes the debate that sees the gynecologist Doléris and the sociologist Durkheim among the protagonists, allowing us to observe in what terms and with what observances, at the gates of the Great War, sexuality entered debates, as well as in schools and institutes; on the other hand, it helps in the understanding of a multifaceted, eclectic figure, that of the putative father of organicist functionalism, a fundamental piece for the entire history of sociology, Émile Durkheim. Even today the figure of the sociologist is rather debated and moves within a paradox that sees him as both a progressive and a conservative
Bringing Hidden Organizations Out of the Shadows: Introduction to the Special Issue
No full textThis introduction to the special issue describes hidden organizations, offers several reasons for the lack of research on these collectives, and explains how this collection of articles helps move us forward in efforts to empirically study hidden organizations. After providing background information on the history of this special issue, the five articles published here are described in terms of the type of collective examined, the theories and methods used, and the key research questions addressed. Three observations about the published pieces are made: being hidden requires communicative effort; hiddenness is usefully understood in terms of identity management; and any discussion of hidden organizations raises ethical considerations. The piece closes with acknowledgements and a call for continued conceptual/theoretical and empirical research into hidden organizations.This is an introduction to a special issue on Hidden Organizations edited by the author. Published online before print: July 19, 2015
Losses of NG2 and NeuN immunoreactivity but not astrocytic markers during early reperfusion following severe focal cerebral ischemia
No full textDiane R. Lee, Stephen C. Helps, Ian L. Gibbins, Michael Nilsson, Neil R. Sim
Consumers' attitudes towards product care: An exploratory study of motivators, ability factors and triggers
No full textTo contribute to a more sustainable way of consumption, products should stay usable as long as possible. Therefore, it is necessary to take care of products. Product care should be understood as any action that helps prolonging the lifetime of a product, such as maintenance, repair etc. These product care activities can be conducted by the consumer or by a service. Our interview study helps to understand consumers’ current product care behaviour towards products of different categories. Our study is based on Fogg’s behaviour model, which states that motivation, ability and triggers have to be present at the same time to lead to certain behaviour. We were able to identify different motivators (e.g. pleasure, price, functionality), ability factors (e.g. tools, time and effort) and triggers (e.g. appearance triggers, social triggers) for product care. Based upon the findings of this study, strategies that enhance product care are suggested and relevant aspects for future research are proposed.Marketing and Consumer Researc
Slides: How open science helps researchers succeed
No full textSlides based on eLife article:McKiernan, E. C., Bourne, P. E., Brown, C. T., Buck, S., Kenall, A., Lin, J., McDougall, D., Nosek, B. A., Ram, K., Soderberg, C. K., Spies, J. R., Thaney, K., Updegrove, A., Woo, K. H., & Yarkoni, T. How open science helps researchers succeed. eLife 2016;10.7554/eLife.16800</div
Beginning Programming with C++ For Dummies
No full textLearn to program with C++ quickly with this helpful For Dummies guide Beginning Programming with C++ For Dummies, 2nd Edition gives you plain-English explanations of the fundamental principles of C++, arming you with the skills and know-how to expertly use one of the world's most popular programming languages. You'll explore what goes into creating a program, how to put the pieces together, learn how to deal with standard programming challenges, and much more. Written by the bestselling author of C++ For Dummies, this updated guide explores the basic development concepts and techniques of C++ from a beginner's point of view, and helps make sense of the how and why of C++ programming from the ground up. Beginning with an introduction to how programming languages function, the book goes on to explore how to work with integer expressions and character expressions, keep errors out of your code, use loops and functions, divide your code into modules, and become a functional programmer. Grasp C++ programming like a pro, even if you've never written a line of code Master basic development concepts and techniques in C++ Get rid of bugs and write programs that work Find all the code from the book and an updated C++ compiler on the companion website If you're a student or first-time programmer looking to master this object-oriented programming language, Beginning Programming with C++ For Dummies, 2nd Edition has you covere
Beyond Sentence-Level End-to-End Speech Translation: Context Helps
No full textDocument-level contextual information has shown benefits to text-based machine translation, but whether and how context helps end-to-end (E2E) speech translation (ST) is still under-studied. We fill this gap through extensive experiments using a simple concatenation-based context-aware ST model, paired with adaptive feature selection on speech encodings for computational efficiency. We investigate several decoding approaches, and introduce in-model ensemble decoding which jointly performs document- and sentence-level translation using the same model. Our results on the MuST-C benchmark with Transformer demonstrate the effectiveness of context to E2E ST. Compared to sentence-level ST, context-aware ST obtains better translation quality (+0.18-2.61 BLEU), improves pronoun and homophone translation, shows better robustness to (artificial) audio segmentation errors, and reduces latency and flicker to deliver higher quality for simultaneous translation
The practice of going helps children to stop:The importance of context monitoring in inhibitory control
No full textHow do we stop ourselves during ongoing action? Recent work implies that stopping per se is easy given sufficient monitoring of contextual cues signaling the need to change action. We test key implications of this idea for improving inhibitory control. Seven- to 9-year-old children practiced stopping an ongoing action or monitoring for cues that signaled the need to go again. Both groups subsequently showed better response inhibition in a Stop-Signal task than active controls, and practice monitoring yielded a dose-response relationship. When monitoring practice was optimized to occur while children engaged in responding, the greatest benefits were observed—even greater than from practicing stopping itself. These findings demonstrate the importance of monitoring processes in developing response inhibition and suggest promising new directions for intervention
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