410 research outputs found

    Growth hormone (GH) profiles in response to continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 in children with GH deficiency.

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    Six children presenting with partial growth hormone (GH) deficiency (mean GH peak in two different tests, 8.0 +/- 1.3 micrograms/l) aged 8-10.3 years (mean, 2.7 +/- 0.9 years) were treated for 6 months by continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 (GHRH(1-29)-NH2); 24-hour GH profiles and height velocity were measured. A biphasic effect of GHRH(1-29)-NH2 infusion was observed. After an early substantial increase in the 24-hour integrated concentration of GH, from 1.6 +/- 0.1 to 3.5 +/- 0.7 micrograms/l/minute, a subsequent consistent decrease occurred by 3 months, which was more pronounced after 6 months (mean 24-hour integrated concentration of GH, 1.9 +/- 0.9 micrograms/l/minute). This effect reflects modification of both pulse amplitude and frequency of GH secretion. At the end of the study, one child had complete suppression of GH secretion and two others showed only one peak above 5 micrograms/l during a 24-hour period. No correlation was found between these changes and height velocity. Three children did not grow significantly; the other three children who had a growth response to GHRH(1-29)-NH2 were those with the lowest 24-hour integrated GH concentration at the end of the study. The possible mechanisms involved in this biphasic effect, including GHRH antibodies, changes in somatostatin levels and/or desensitization of pituitary GHRH receptors, have been investigated

    Impact of the microbial pesticide Bacillus thruingiensis Berliner subsp. kurstaki on Hymenopterous parasites of the imported cabbageworm, Pieris rapae (L.) (Lepidoptera: Pieridae)

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    Three formulations of Bacillus thuringiensis Berliner subsp. kurstaki (Dipel 4L, Dipel 2X, and ABG-6167) were compared with the synthetic pyrethroid perrnethrin ( common name Pounce 3. 2 EC) for insecticidal activity and impact upon parasitism of the imported cabbageworrn, Pieris rapae (L.) (Lepidoptera: Pieridae) in field broccoli (CV Packrnan) from fall 1986 to spring 1988. Perrnethrin, Dipel 4L, and ABG-6167 were not significantly different in their efficacy towards imported cabbageworm larvae. Parasitization of P. rapae by the larval parasite Cotesia glomerata (L.) (Hymenoptera: Braconidae) and the pupal parasite Pteromalus puparum (L.) (Hyrnenoptera: Pteromalidae) continued after spraying in the B. thuringiensis plots, but was not significantly different from perrnethrin. However, 100% of the P. rapae chrysalids recovered were parasitized by P. puparum. The impact of seasonal hyperparasitism was compared between .Q. glomerata, and a Yugoslavian strain of Cotesia rubecula (Marshall), an exotic larval parasite of the imported cabbageworm. Four hyperparasites, two of them attacking both~. glomerata and~. rubecula, were found in field plots from 1986-1988. The level of hyperparasitization for the two primary parasites was significantly different. Hyperparasitization averaged only 8.1% for C. glomerata from 1986-1988, but was 37. 9% for C. rubecula from 1987-1988. During the early- to mid-season of 1988, hyperparasite activity was not detectable and C. rubecula outcompeted C. glomerata for hosts; but by mid-season, hyperparasite activity against C. rubecula increased to 100%, causing its populations to crash. C. glomerata then became the dominant parasite of P. rapae. C. rubecula was not recovered in 1989. Hyperparasites may be a limiting factor in establishing C. rubecula in southwestern Virginia. Mortality and successful pupation of P rapae fourth instars parasitized by C. rubecula to B. thuringiensis endotoxin at dosages of 850, 85, and 8.5 I.U./ml was examined. After day two, the LC50's of parasitized fourth instars were approximately thirty times higher than that of unparasitized larvae and by day four, the LC50 response of parasitized fourth instars was 180 times higher than unparasitized larvae. Twenty-five percent of parasitized fourth instars exposed to a concentration of 850 I.U./ml successfully pupated, compared to 76% at 85 I.U./ml and 69% at 8.5 I.U./ml. Parasitized fourth instar P. rapae consume less food and are therefore less susceptible to B. thuringiensis than unparasitized larvae at the same dosages.Ph. D

    Chronique Droit fiscal de l'UE - La Cour apporte des précisions sur les opérations exonérées de TVA

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    International audience[CJUE, 5e ch., 28 févr. 2018, aff. C-307/16, Stanislaw Pienkowski c/ Dyrektor Izby Skarbowej w Lublinie (1re esp.) ; CJUE, 2e ch., 25 juill. 2018, aff. C-5/17, Commissioners for Her Majesty's Revenue and Customs c/ DPAS Limited (2e esp.) ; CJUE, 7e ch., 8 nov. 2018, aff. C-495/17, Cartrans Spedition SRL c/ Directia Generale Regionala a Finantelor Publice Ploiesti - Administratia Judeteana a Finantelor Publice Prahova, Directia Regionale a Finantelor Publice Bucuresti - Administratia Fiscale pentru Contribuabili Mijlocii (3e esp.) ; CJUE, 10e ch., 19 déc. 2018, aff. C-17/18, Virgil Mailat, Delia Elena Mailat, Apcom Select SA (4e esp.) ; CJUE, 4e ch., 19 avr. 2018, aff. C-580/16, Firma Hans Bühler KG c/ Finanzamt de Graz-Stadt (5e esp.)

    Seasonal abundance and biology of hyperparasites and their hosts associated with Pieris rapae (L.) (Lepidoptera: Pieridae) in the Brassica crop system

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    Hyperparasitism of beneficial parasites of Pieris rapae was studied on Brassica crops in Montgomery County, Virginia. The goal of the study was to determine whether the hyperparasites attacking the larval parasites of P. rapae were capable of eliminating an introduced population of the larval parasite Cotesia rubecula (Marshall) (Hymenoptera: Braconidae). Pieris rapae was found to be active from April to November with possibly six generations per year in this region. It was attacked throughout this period by five generations of the larval parasite Cotesia glomerata (L.) (Hymenoptera: Braconidae). Although P. rapae larvae were twice as numerous on broccoli (var. Premium Crop) than on cabbage (var. Rio Verde), a higher proportion of P. rapae larvae was parasitized by C. glomerata on cabbage, indicating that C. glomerata preferred to forage for P. rapae in cabbage. In spring plantings, up to 36.9% of C. glomerata cocoon masses had been affected by the hyperparasite T. galaetopus (Ratzeburg) (Hymenoptera: (Eulophidae) and 23.3% by the hyperparasite Spiloehaleis torvina Cresson (Hymenoptera: Chalcididae). In the fall, 93.2% and 4.2% of the cocoon masses were affected by T. galaetopus and S. torvina, respectively. Tetrastiehus galaetopus activity was observed from May to November, but it was most active after mid July. Tetrastiehus ga/aetopus had little impact on the gregarious C. glomerata, and even though it could affect >90% of the C. glomerata cocoon masses for extended periods, 500/0 of the cocoons in each mass were unaffected. However, it's high reproductive capacity could adversely affect a solitary host such as C. rubecula. Spilochalcis torvina was observed as early as late May but it was most active during the mid summer months. It's reproductive activity ceased by early October even though hosts were abundant in the month which followed. Four generations were seen between June and October. Spilochalcis torvina's hosts were Cotesia orobenae Forbes (Hymenoptera: Braconidae), C. glomerata, and Plutella xylostella (L.) (Lepidoptera: Plutellidae), but the principal host was C. glomerata. However, the proportion of female S. torvina progenies was <31% from the Cotesia spp. hosts and 70% from P. xylostella hosts. Spilochalcis torvina typically hyperparasitized <4 pupae per Cotesia spp. cocoon mass in the field. In laboratory experiments, S. torvina hyperparasitized an average of <7 C. rubecula pupae daily, and the maximum number hyperparasitized was 12. Due to its apparently low reproductive rate in the laboratory, and its low rate of hyperparasitization on hosts in the field, it is unlikely that S. torvina is a danger to populations of parasites like C. rubecula.Master of Scienc

    Chronique Droit fiscal de l'UE - La Cour apporte des précisions sur les opérations exonérées de TVA

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    International audience[CJUE, 5e ch., 28 févr. 2018, aff. C-307/16, Stanislaw Pienkowski c/ Dyrektor Izby Skarbowej w Lublinie (1re esp.) ; CJUE, 2e ch., 25 juill. 2018, aff. C-5/17, Commissioners for Her Majesty's Revenue and Customs c/ DPAS Limited (2e esp.) ; CJUE, 7e ch., 8 nov. 2018, aff. C-495/17, Cartrans Spedition SRL c/ Directia Generale Regionala a Finantelor Publice Ploiesti - Administratia Judeteana a Finantelor Publice Prahova, Directia Regionale a Finantelor Publice Bucuresti - Administratia Fiscale pentru Contribuabili Mijlocii (3e esp.) ; CJUE, 10e ch., 19 déc. 2018, aff. C-17/18, Virgil Mailat, Delia Elena Mailat, Apcom Select SA (4e esp.) ; CJUE, 4e ch., 19 avr. 2018, aff. C-580/16, Firma Hans Bühler KG c/ Finanzamt de Graz-Stadt (5e esp.)

    Spatially explicit farming system modelling for an efficient agri-environmental policy design

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    A mathematical programming model is developed and associated to a spatial pattern index (Ripley L function) to analyse the optimal reserve design and implementation for the Little Bustard conservation in Plaine de Niort. The model structure corresponds to three spatial levels, fields, farm and landscape. Simple in terms of area representation, it is detailed in terms of farm behaviour and spatially explicit. The model is applied in a normative and in a positive way. The major findings of the normative approach relate to the trade-offs between the reserve pattern and its cost. It was found that the environmentally optimal reserve, which is randomly dispersed across the zone, is the most costly one. Within the positive approach, it is illustrated that the various reserve patterns generated within the normative approach can be obtained through relatively simple uniform contract structures. The most effective contract structure is a degressive set of two payments enabling the farms to enroll at least a small share of their land.Biodiversity, spatial optimization, mathematical programming, Environmental Economics and Policy, Farm Management,

    Studies on Conura torvina (Hymenoptera: Chalcididae) Reproduction and biology in Relation to Hosts in Brassica Crops

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    Conura torvina (Cresson) (Hymenoptera: Chalcididae) is a solitary pupal endoparasite of numerous insect species. In Brassica crops it acts as a parasite of Plutella xylostella (L.) (Lepidoptera: Plutellidae) and was found as a hyperparasite of Cotesia rubecula (Marshall) (Hymenoptera: Braconidae) and several other parasitoid species. Cotesia rubecula was introduced into Virginia in 1987 as a biological control agent for Pieris rapae (L.) (Lepidoptera: Pieridae), and because C. torvina was thought to have eliminated this population of C. rubecula, studies of C. torvina's reproductive biology and behavior were initiated. A study using plants laden with "trap hosts" to detect C. torvina activity in the spring indicated no activity until late June, but proved trap host sampling to be an efficient and effective method of monitoring C. torvina activity. Studies of C. torvina's ability to reproduce in C. rubecula pupae of different ages indicated that C. torvina can successfully parasitize pupae at all stages of development, but was most successful in young to middle aged pupae. Studies of C. torvina's host species preference indicated the larger host species such as P. xylostella were preferred. Equal numbers of P. xylostella and C. rubecula were parasitized, but a greater proportion of fertile eggs were laid in P. xylostella. Smaller host species were often ignored. Host dissection studies indicated that caged C. torvina were inefficient at host finding and oviposition. Superparasitism was common, but declined as the females gained oviposition experience. Experienced C. torvina produced an average of 8.25 progenies per day for a period of 12 days when provided with 13 P. xylostella hosts each day. Conura torvina produced up to 14 progenies a day when provided 3 26 hosts. Dissection of C. torvina ovaries indicated three ovarioles per ovary with a mean of 9.2 and maximum of 15 mature eggs per female. Host dissection indicated that a mean of 18 and maximum of 30 eggs could be laid per day. New eggs were produced as oviposition occurred. Significantly larger eggs were laid in P. xylostella than in C. rubecula, and significantly more eggs were laid in C. rubecula than in P. xylostella. From these data and data from earlier studies I concluded that C. torvina has a poor reproductive ability and its impact as a hyperparasite is limited to the summer months. This makes C. torvina an unlikely cause of C. rubecula's disappearance.Ph. D

    Synthesis and structure of LiCaPO<sub>4</sub> by combined X-ray and neutron powder diffraction

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    LiCaPO4 has been synthesized and characterized by combined X-ray and neutron powder diffraction. The phase adopts the trigonal space group P3,c, a=7.5247(1) Å, c=9.9657(2) Å. The structure is composed of a threedimensional framework of vertex-sharing LIO4 and PO4 tetrahedra enclosing five-sided channels running parallel to the c axis, which are occupied by the Ca2+ ions. This structure is isotypic with LiNaSO4 but is believed to be novel amongst phosphates. The combined use of X-ray and neutron scattering is found to improve significantly the determination of both the light (Li) and heavy (Ca) atom positional and thermal parameters, and it is proposed that this strategy may be useful in the structural characterization of more complex lithium-containing solids, containing heavier elements of similar neutron scattering length such as La and Sr, where neutron diffraction alone is insufficient to determine the site ordering uniquely.</p

    Comparative foraging ecology of two broad-ranging migrants, grey plover Pluvialis Squatarola and whimbrel Numenius Phaeopus (Aves: Charadrii), in tropical and temperate latitudes of the Western Indian Ocean

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    Bibliography: leaves 186-205.A seasonal study of the nonbreeding foraging ecology of Grey Plovers and Whimbrels was undertaken at the Zwartkops estuary, South Africa, and additional data were collected from a variety of sites in tropical and south temperate latitudes during the premigratory period. The main objective of the study was to provide comparative data on shorebird foraging ecology in the southern hemisphere, in order to contribute to the general understanding of shorebird foraging behaviour and migration patterns
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