7,916 research outputs found
Dedication of Branford Price Millar Library
No full textRecorded in the lobby of Branford P. Millar Library. Speakers are PSU President Joseph Blumel, Theresa Millar, Andrew Millar, Gordon Hearn (Dean of the School of Social Work), Miles Romney (Vice Chancellor for Academic Affairs, Oregon State System of Higher Education), Frank Rodgers (PSU Library Director)
Determining information systems contribution to manufacturing agility for SME's in dynamic business environments
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Since the concept of agile manufacturing was coined in the early nineties, the study of the contribution of information systems to agility has lacked a thorough analysis. Information systems have been labelled in the academic literature as critical, key and important in achieving and supporting agility. On the other hand, there is a large number of documented cases where IS have failed to deliver expected benefits. The aim of this study has been to determine the contribution of information systems to manufacturing agility. This study required the development of a research survey with the purpose of testing seven IT/IS proficiency characteristics of agility, three characteristics of a dynamic business environment and the type of IS applications used in manufacturing organisations. The analysis of the survey suggested that the business environment does not exert great influence on the IT/IS proficiency characteristics; also no association was found with the use of a specific type of manufacturing IS and the IT/IS proficiency characteristics. The results of the analysis of the survey were further expanded in a multiple case-study. Profitable SMEs with some agile processes in place participated in a multiple case-study that covered the agility of manufacturing and other business process, business and IT strategies, and skills and expertise of employees affecting the realisation of benefits of IS. The study revealed that information systems are neither the most important, the most overwhelming, the most difficult part of the equation to achieve agility nor are they principal enablers of manufacturing. Identified principal enablers of agile manufacturing include providing training to employees, right attitude of workforce towards change, having a flexible manufacturing base and people's knowledge and skills. Moreover, the use of low performing information systems was not an impediment to moving towards agility. The results of the multiple case-study tend to indicate that information systems play a more significant role in enhancing agility once principal enablers have been implemented. Certainly, IS may be required to support manufacturing agility but that information systems are not sufficient to achieve it. The study revealed that skills and expertise of people were used as means to overcome the problems and shortcomings generated by low performing IS. A new taxonomy of enablers of agility has been defined, identifying IS as second-order enablers of agility. Also, a proposed new framework has considered the adoption of an IT strategy to influencing a business strategy as a mean of enhancing the agility of business processes already achieved through the implementation of principal enablers
Éd. Will, C. Orrieux, « Prosélytisme juif » ? Histoire d'une erreur, 1992
No full textMillar Fergus. Éd. Will, C. Orrieux, « Prosélytisme juif » ? Histoire d'une erreur, 1992. In: Topoi, volume 3/1, 1993. pp. 299-304
FLOWERING LOCUS C -dependent and -independent regulation of the circadian clock by the autonomous and vernalization pathways
No full textBackground
The circadian system drives pervasive biological rhythms in plants. Circadian clocks integrate endogenous timing information with environmental signals, in order to match rhythmic outputs to the local day/night cycle. Multiple signaling pathways affect the circadian system, in ways that are likely to be adaptively significant. Our previous studies of natural genetic variation in Arabidopsis thaliana accessions implicated FLOWERING LOCUS C (FLC) as a circadian-clock regulator. The MADS-box transcription factor FLC is best known as a regulator of flowering time. Its activity is regulated by many regulatory genes in the "autonomous" and vernalization-dependent flowering pathways. We tested whether these same pathways affect the circadian system.
Results
Genes in the autonomous flowering pathway, including FLC, were found to regulate circadian period in Arabidopsis. The mechanisms involved are similar, but not identical, to the control of flowering time. By mutant analyses, we demonstrate a graded effect of FLC expression upon circadian period. Related MADS-box genes had less effect on clock function. We also reveal an unexpected vernalization-dependent alteration of periodicity.
Conclusion
This study has aided in the understanding of FLC's role in the clock, as it reveals that the network affecting circadian timing is partially overlapping with the floral-regulatory network. We also show a link between vernalization and circadian period. This finding may be of ecological relevance for developmental programing in other plant species
Author Correction: Identification of a novel cAMP dependent protein kinase A phosphorylation site on the human cardiac calcium channel
No full textThe original version of this Article contained a typographical error in the spelling of the author A. Harvey Millar, which was incorrectly given as Harvey A. Millar. This has now been corrected in the PDF and HTML versions of the Article and in the Supplementary Information
Monniotus ramosus Millar 1988
No full textMonniotus ramosus Millar, 1988 (Figure 18) Monniotus ramosus Millar, 1988: 826 fig 1, Mozambique. Stations. TR 1 (MNHN A 1 MON 6). Madagascar, Tulear. Vasseur col. 1964 (MNHN A 1 MON 4). A single colony of about thirty zooids was collected during the Atimo Vatae survey (Fig; 18 A), but a second colony from Tulear comes from P. Vasseur material. The dichotomic ramification of the colonies is that described and figured n by Millar. Several ramified lobes arise from a common base; each group measures about 3.5cm. The thorax (Fig. 18 C) and the abdomen (Fig. 18 B) are enclosed independently in a sandy tunic but their post-abdomens are united in a common peduncle. The colony from the south of Madagascar is only female with ovaries and larvae. The colony from Tulear is male with a short double row of testis vesicles in the post-abdomen at a short distance from the gut loop. All zooids have 15 rows of stigmata, without parastigmatic vessels (Fig. 18 D). The larvae 1.2mm long are as described and figured by Millar. This species is recollected for the first time. Its distribution is restricted to Madagascar. Other species of Monniotus are known from the Pacific Ocean: M. australis (Kott, 1957) and M. radiatus Kott, 1992 from Australia have only 10 rows of stigmata and parastigmatic vessels. M. papillosus Monniot F. & Monniot C., 2001 from New Guinea has 18 rows of stigmata with parastigmatic vessels. M. pacificus Monniot F.& Monniot C., 2001 from Palau has 20 rows of 40 stigmata, high papillae and an areolated stomach. M. paucistigma Monniot F. & Monniot C., 2008 from New Guinea has only 4 rows of stigmata, papillae both on transverse and parastigmatic vessels.Published as part of Monniot, Françoise, 2012, Some ascidians from the southern coast of Madagascar collected during the " AtimoVatae " survey, pp. 1-42 in Zootaxa 3197 on page 22, DOI: 10.5281/zenodo.24618
Millar, Mrs. C[harles] C. Hoyer, [n.y.] [n.m.] [n.d.]
No full textcopy of published letter from Jobe, August 2000. transcription only; same text as [1895] [January] [29] to Beatrix Millar and now filed there 8/3/10 RDSUnknow
Fundamentals of Soil Science, par C. E. Millar, L. M. Turk et H. D. Foth, 1965
No full textPédro Georges. Fundamentals of Soil Science, par C. E. Millar, L. M. Turk et H. D. Foth, 1965. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 89, 1, 1966. p. 153
The mentoring cycle
No full textThe aim of this chapter is to explore the mentoring cycle and in particular, the concept of phases within the context of the mentoring relationship. The chapter begins by outlining a number of models that describe how mentoring relationships develop over time, such as Kram (1980, 1983), Missirian (1982), Clutterbuck (1985; 2004), and Westland (2015). The mentee and mentor perspective is explored by understanding the experiences of each, through insight, during various stages of the relationship. Next, the author identifies a number of empirical studies that have ‘tested’ the models to better understand their application to specific contexts (Westland, 2015). The models are compared and contrasted in order to identify the challenges associated with the concept of the mentoring cycle. The author also considers factors that influence the mentoring cycle and the effectiveness of the mentoring relationship. Finally, the author considers the implications of the mentoring cycle from a number of perspectives: mentoring relationships, program design, training for mentees and mentors, and future research agendas for both researchers and practitioners
Proline-rich tyrosine kinase 2 mediates gonadotropin-releasing hormone signaling to a specific extracellularly regulated kinase-sensitive transcriptional locus in the luteinizing hormone beta-subunit gene
No full textG protein-coupled receptor regulation of gene transcription primarily occurs through the phosphorylation of transcription factors by MAPKs. This requires transduction of an activating signal via scaffold proteins that can ultimately determine the outcome by binding signaling kinases and adapter proteins with effects on the target transcription factor and locus of activation. By investigating these mechanisms, we have elucidated how pituitary gonadotrope cells decode an input GnRH signal into coherent transcriptional output from the LH beta-subunit gene promoter. We show that GnRH activates c-Src and multiple members of the MAPK family, c-Jun NH2-terminal kinase 1/2, p38MAPK, and ERK1/2. Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. The locus of action of ERK was specifically mapped to early growth response-1 (Egr-1) DNA binding sites within the LH beta-subunit gene proximal promoter, which was also activated by p38MAPK, but not c-Jun NH2-terminal kinase 1/2. Egr-1 was confirmed as the transcription factor target of ERK and p38MAPK by blockade of protein expression, transcriptional activity, and DNA binding. We have identified a novel GnRH-activated proline-rich tyrosine kinase 2-dependent ERK-mediated signal transduction pathway that specifically regulates Egr-1 activation of the LH beta-subunit proximal gene promoter, and thus provide insight into the molecular mechanisms required for differential regulation of gonadotropin gene expression
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