45 research outputs found
PhT Class 2009
No full textOn photo: First row (left to right): Elizabeth Baril, Steven Bastian, Brenda M. Davis, Lindsay Brown, Jessica DickinsonSecond row (left to right): Shawna Doty, Kristin Ewertz, Erica Fenili, Jerod Gard, Katie Harrell, Shelli J. HillThird row (left to right): Rachel L. Kremmer, B. J. Lehecka, Kimmie Sue Lennington, Penny Mensing, Jason Mettling, Jarvis OgdersFourth row (left to right): Angela Overman, Jennifer Porter, Mark Robertson, Justin Rohrberg, Cindy C. Sappock, Stevie ScottFifth row (left to right): Sarah N. Stucky, Brenda L. Swanson, Janette Travis, Matt Weber, Jonathan YoungDigitized by University Libraries' Technical Services Institutional Repository & Digitization group.Personal and non-profit use only. Contact [email protected] if you have any questions
Rap1-suppressed tumorigenesis is concomitant with the interference in Ras effector signaling
No full textAbstractExpression of Rap1 blocks epithelial growth factor-induced extracellular signal-regulated kinases (ERKs) activation. However, recent studies demonstrated that Rap1 mediates ERKs activation induced by nerve growth factor. The anti-oncogenic effect of Rap1 has been reported but its mechanism remains unclear. To evaluate the correlation between the anti-transforming effect and the activation of ERKs, we transfected rap1 cDNA into Hep3B cells and selected stable transfectants. The Rap1 transfectants completely lost their intrinsic tumorigenicity in Balb/c nude mice. Both insulin and 12-O-tetradecanoyl phorbol-13-acetate (TPA)-stimulated ERK activations were also blocked. Our findings suggest that Rap1-suppressed tumorigenicity is concomitant with ERKs inhibition
Galphai protein-dependant extracellular signal-regulated kinase-1/2 activation is required for HIV-1 reverse transcription
No full textInternational audienc
The Scholarly Impact of Books Acquired via Approval Plan Selection, Librarian Orders, and Patron-Driven Acquisitions as Measured by Citation Counts
No full textPatron-driven acquisition has been an important, if contentious, topic for decades, with numerous programs having been piloted, adopted, and reported on, largely favorably, in the library literature. Still, questions and doubts persist for academic libraries, especially where the composition of vendor plans and packages and the judgment of patrons are concerned. Past literature has approached the assessment of patron-driven acquisition by analyzing circulation/usage, comparing peer-library holdings, seeking patrons’ or librarians’ judgments of utility and suitability, looking for evidence of collection imbalances, and testing for overlap in patrons’ and librarians’ purchases. To contribute to this literature, this study addresses scholarly impact and examines whose selections—approval plans’, librarians’, or patrons’—have been most heavily cited. For the social sciences, the sciences, and the humanities, the authors gathered topic-matched random samples of books acquired via approval plans and librarian orders during the first five years of operation of their institutions’ interlibrary loan purchase-on-demand patron-driven acquisition program and compared their citation counts to the counts of books acquired via the program. Google Scholar was employed to tally citations
Cell surface CCR5 density determines the intensity of T cell migration towards rheumatoid arthritis synoviocytes.
No full textInternational audienc
Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization
No full textInternational audienc
Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
No full textThe chemokine CCL5 regulates the in vivo cel surface of its receptor, CCR5
No full textInternational audienc
The strength of the chemotactic response to a CCR5 binding chemokine is determined by the level of cell surface CCR5 density
No full textInternational audienc
