586 research outputs found
CORE-Net: exploiting prior knowledge and preferential attachment to infer biological interaction networks
No full textThe problem of reverse engineering in the topology of functional interaction networks from time-course experimental data has received considerable attention in literature, due to the potential applications in the most diverse fields, comprising engineering, biology, economics and social sciences. The present work introduces a novel technique, CORE-Net, which addresses this problem focusing on the case of biological interaction networks. The method is based on the representation of the network in the form of a dynamical system and on an iterative convex optimisation procedure. A first advantage of the proposed approach is that it allows to exploit qualitative prior knowledge about the network interactions, of the same kind as typically available from biological literature and databases. A second novel contribution consists of exploiting the growth and preferential attachment mechanisms to improve the inference performances when dealing with networks which exhibit a scale-free topology. The technique is first assessed through numerical tests on in silico random networks, subsequently it is applied to reverse engineering a cell cycle regulatory subnetwork in Saccharomyces cerevisiae from experimental microarray data. These tests show that the combined exploitation of prior knowledge and preferential attachment significantly improves the predictions with respect to other approaches
Inferring scale-free networks via multiple linear regression and preferential attachment2008 16th Mediterranean Conference on Control and Automation
No full textThe problem of reverse-engineering the topology of interaction networks from time-course experimental data has been the subject of a considerable research effort in the last years, due to the potential applications in the most diverse fields, comprising engineering, biology, economics and social sciences. An important insight into such topic was brought by the introduction of the concept of scale-free topology, whose implications have been widely discussed in literature over the last decade. The aim of this work is to investigate whether it is possible to improve the performances of an inference technique, based on dynamical linear systems and multiple linear regression, by exploiting the same mechanisms that underpin scale-free networks generation, i.e. growth and preferential attachment (PA). The work is prominently concerned with applications in the biological domain, though the algorithm can be in principle adapted also to other frameworks. A statistical evaluation is performed, by using numerically simulated networks, showing that the growth and PA mechanisms actually improve the inference power of the considered technique. Finally the method has been applied to a biological case-study, validating the results against experimental data available in literature
Pride or shame? Sulla letteratura working class di Alberto Prunetti
No full textThe article proposes a reading of the novels of Alberto Prunetti, in the light of his critical reflection on working class literature. The author studies the relationship of Prunetti’s reflection with the debate on ‘literature and industry’ held in the ‘Menabò’ in the 1960s, in order to appreciate innovations and limits of this new perspective. A comparison is then proposed with contemporary French working class literature, in particular with the novels of Edouard Louis. On the basis of the different treatment of the two competitive concepts of Pride and Shame used by the writers, the author concludes that Prunetti’s writing is characterized by a heroic attitude, while Louis’ one, influenced by Ernaux and Eribon, is more pessimistic and intersectional
The Popular Politicization of Translating: Brunetto Latini and the Caesarian Orations
No full textThe contribution discusses the results of the recent critical edition of the volgarizzamento
of Cicero’s “Orazioni cesariane” written by Brunetto Latini. In particular,
the problems of attribution, dating and commissioning of the translation are
considered. The author proposes to identify the context of Brunetto Latini’s operation
in the preparatory period for the peace of Cardinal Latino Malabranca in Florence
(1280). Some conclusions are drawn from this discussion, in particular in relation
to the “Republican” anti-Cesarianism of Brunetto and his political vision of the
activity of translation
Exploiting prior knowledge and preferential attachment to infer biological interaction networks2009 17th Mediterranean Conference on Control and Automation
No full textDall’università di Parigi a frate Alberto. Immaginario antimendicante ed ecclesiologia vernacolare in Giovanni Boccaccio
No full textL'articolo analizza l'idea boccacciana della novità mendicante, in particolare nel Decameron. Per spiegare questa presenza importante, l’autore fornisce alcuni elementi di contesto, analizzando il ruolo dei frati nella Napoli angioina e nella Firenze della seconda metà del Trecento. Il punto di vista di Boccaccio risulta in rapporto con quello della élite fiorentina, sensibile ad alcuni elementi della predicazione “spirituale” dei fraticelli, che però l’autore del Decameron miscela con la tradizione letteraria antimendicante, che dalla Francia si è trasmessa in Italia. Viene poi analizzato il trattamento della materia nel Decameron, dove questo tema diventa l’occasione per riflettere sulla Chiesa e sulle questioni del linguaggio. In Appendice si pubblica l’edizione critica del testo satirico Vehementi nimium commotus dolore, prodotto in ambiente federiciano nel ’200 e trascritto e rielaborato da Boccaccio nello Zibaldone Laurenziano.\ud
The paper examines the presence of the Mendicant Friars in the works of Giovanni Boccaccio, especially the Decameron.The author provides some elements of the different socio-historical contexts known by Boccaccio (Naples and Florence) in order to explain such a consistent presence. Boccaccio shares his point of view about the historical role of the Friars with the Florentine élite of his time, which was sensitive to the predication by the Fraticelli, but he mixed this point of view with the issues of the antimendicant imagery, born in France and implanted in Italy. Consequently, the treatment of the topics is analyzed in the Decameron, where it becomes the occasion to reflect about the Church and the language. In the Appendix, the author provides the critical edition of the satirical text Vehementi nimium commotus dolore, produced at the court of Frederick II in 1241-1243 and transcribed and rewritten by Boccaccio in the Zibaldone Laurenziano
Maestri secolari, Frati mendicanti e autori volgari. Immaginario antimendicante ed ecclesiologia in vernacolare, da Rutebeuf a Boccaccio
No full textThe article is the first study on the anti-mendicant polemic in the imaginary of Italian medieval literature. It will argue that Italian authors inherited from French sources – especially Rutebeuf and Jean de Meun – an approach that sought to characterize friars from the mendicant orders as fundamentally invested in a project of domination over the wider societas christiana, a vision embodied by the character of Falsembiante, half-Dominican and half-Franciscan. This polemical paradigm brought medieval authors to reflect more widely upon the structure of the Church and its presence in society, and helped prompt the formation of a vernacular ecclesiology. The author then seeks to relate this ecclesiology to the broader religious and cultural context of the time.
L’articolo è il primo studio complessivo sull’immaginario antimendicante nella letteratura italiana medivale. Gli autori italiani hanno ereditato dalle fonti francesi – in particolare Rutebeuf e Jean de Meun – un approccio che individuava nei frati mendicanti i protagonisti di un progetto di dominazione sulla societas christiana (impersonata da Falsembiante, metà francescano e metà domenicano). Questo paradigma ha indotto gli scrittori a riflettere sulla struttura della Chiesa e sulla sua presenza nella società, proponendo una ecclesiologia in volgare. L’autore studia questa ecclesiologia alla luce dei contesti religiosi e culturali dell’epoca
Recensione a: Sara J. Newman, Aristotle and Style, Lewingston-Queenston-Lampeter: The Edwin Mellen Press, 2005
No full textWell fitting into the recent Aristotelian bibliography, as Alan G. Gross rightly points out in his preface to the book, Sara Newman’s work offers a very engaged commentary to the relationship between Aristotle’s theory and practice of metaphor and contemporary under-standings of it. As in a roundtrip, the author comes back at the end of her analysis to her open-ing question ‘Why Aristotle and Style?’ (p. 1) which she can now answer saying that “In spite of its limitations, Aristotle notion of style is more than ornamental and substitutive; it operates consistently in his texts to enhance, to facilitate, and to systematically guide certain concep-tual inquiries” (p. 263). Indeed the book has not only the merit to stress the role of Aristotle’s metaphor within the clarifying function of style and consequently its link with the logical process of persuasion, but it is also an important contribution to vindicate Aristotle’s rights in the development of the modern conceptual theory of metaphor
Blow up analysis, existence and qualitative properties of solutions for the two dimensional Emden-Fowler equation with singular potential
No full textMotivated by the study of a two-dimensional point vortex model, we analyze the following Emden-Fowler type problem with singular potential
\bgin{equation}\graf{
-\lapl u=\lm \dfrac{\e{u}}{\ino\e{u} \dx} & \mbox{in}\hspace{.2cm} \om,
\nonumber\\\\
\hspace{.55cm}u=0 & \hspace{-.05cm} \mbox{on}\hspace{.2cm} \om,
}\end{equation}
where \displaystyle V(x)=\frac{ K(x)}{|x|^{2\al}} with , 0< a\leq K(x)\leq b<+\infty, \fal{x}{\om} and \|\nabla K\|_\i\leq C.
We first extend various results, already known in case , to cover the case . In particular, we study the concentration-compactness problem and the mass quantization properties, obtaining some existence results.
Then, by a special choice of , we include the effect of the angular momentum in the system and obtain the existence of axially symmetric one peak non radial blow up solutions
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