1,944 research outputs found
MARY VIRGINIA NEFF Violin MASTER'S RECITAL Saturday, November 9, 2002 1:30 p.m. Lillian H. Duncan Recital Hall
No full textRecording of performance is incomplete.PROGRAM: Adagio in E major, K.261 / Wolfgang Amadeus Mozart -- Rondo in C major, K.373 / Wolfgang Amadeus Mozart -- Sonata / Aaron Copland -- Sonate / Maurice RavelThis recital is given in partial fulfillment of the requirements for the Master of Music degree
sj-pdf-1-asu-10.1177_00031348221084967 – Supplemental Material for Unmasking the Confounder: The Inherent Physiologic Variability of Swine During an Automated Experimental Model of Ischemia-Reperfusion Injury
No full textSupplemental Material, sj-pdf-1-asu-10.1177_00031348221084967 for Unmasking the Confounder: The Inherent Physiologic Variability of Swine During an Automated Experimental Model of Ischemia-Reperfusion Injury by Symonne C. Martin, BS, Nathaniel Hauser, MS, Antonio C. Renaldo, BS, Magan Lane, BS, James E. Jordan, PhD, Hisham I. Qadri, BS, Nicholas Mouser, BS, Elaheh Rahbar, PhD, Timothy K. Williams, MD and Lucas P. Neff, MD in The American Surgeon</p
Scotch broom: biology and management in the Pacific Northwest : cytisus scoparius (L.) link
No full textThis archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from captionAdditional authors: K. Neff, E. Coombs, R. Parker, G. Miller, L.C. Burril"A Pacific Northwest Extension publication.""Revised August 1994. Revised July 2008"--p. [8]Includes bibliographical references (p. 6-7)Mode of access: Internet from the Oregon Government Publications Collection
Co-ingestion of protein or a protein hydrolysate with carbohydrate enhances anabolic signaling, but not glycogen resynthesis, following recovery from prolonged aerobic exercise in trained cyclists
No full textPurpose: The effect of carbohydrate (CHO), or CHO supplemented with either sodium caseinate protein (CHO–C) or a sodium caseinate protein hydrolysate (CHO–H) on the recovery of skeletal muscle glycogen and anabolic signaling following prolonged aerobic exercise was determined in trained male cyclists [n = 11, mean ± SEM age 28.8 ± 2.3 years; body mass (BM) 75.0 ± 2.3 kg; VO2peak 61.3 ± 1.6 ml kg−1 min−1]. Methods: On three separate occasions, participants cycled for 2 h at ~ 70% VO2peak followed by a 4-h recovery period. Isoenergetic drinks were consumed at + 0 and + 2 h of recovery containing either (1) CHO (1.2 g kg −1 BM), (2) CHO–C, or (3) CHO–H (1.04 and 0.16 g kg−1 BM, respectively) in a randomized, double-blind, cross-over design. Muscle biopsies from the vastus lateralis were taken prior to commencement of each trial, and at + 0 and + 4 h of recovery for determination of skeletal muscle glycogen, and intracellular signaling associated with protein synthesis. Results: Despite an augmented insulin response following CHO–H ingestion, there was no significant difference in skeletal muscle glycogen resynthesis following recovery between trials. CHO–C and CHO–H co-ingestion significantly increased phospho-mTOR Ser2448 and 4EBP1 Thr37/46 versus CHO, with CHO–H displaying the greatest change in phospho-4EBP1 Thr37/46. Protein co-ingestion, compared to CHO alone, during recovery did not augment glycogen resynthesis. Conclusion: Supplementing CHO with intact sodium caseinate or an insulinotropic hydrolysate derivative augmented intracellular signaling associated with skeletal muscle protein synthesis following prolonged aerobic exercise
Changes in photoperiod or temperature alter the functional relationships between phytochromes and reveal roles for phyD and phyE
No full textThe phytochromes are one of the means via which plants obtain information about their immediate environment and the changing seasons. Phytochromes have important roles in developmental events such as the switch to flowering, the timing of which can be crucial for the reproductive success of the plant. Analysis of phyB mutants has revealed that phyB plays a major role in this process. We have recently shown, however, that the flowering phenotype of the phyB monogenic mutant is temperature dependent. A modest reduction in temperature to 16 degrees C was sufficient to abolish the phyB mutant early-flowering phenotype present at 22 degrees C. Using mutants null for one or more phytochrome species, we have now shown that phyA, phyD, and phyE, play greater roles with respect to phyB in the control of flowering under cooler conditions. This change in the relative contributions of individual phytochromes appears to be important for maintaining control of flowering in response to modest alterations in ambient temperature. We demonstrate that changes in ambient temperature or photoperiod can alter the hierarchy and/or the functional relationships between phytochrome species. These experiments reveal new roles for phyD and phyE and provide valuable insights into how the phytochromes help to maintain development in the natural environment
Fluid-rock interaction, skarn genesis, and hydrothermal alteration within an upper crustal fault zone (Island of Elba, Italy)
No full textThe Terranera magnetite-hematite-pyrite deposit of the Island of Elba (Italy) is an historical skarn deposit hosted by a fault zone of regional importance (Zuccale Fault) and by its hanging wall rocks.
We combine field observations with petrographic data, electron probe microanalyses (EPMA), XRPD data, fluid inclusion microthermometry, and element imaging by Laser Ablation-Inductively Coupled Plasma-Time of Flight Mass Spectrometry (LA-ICP-TOFMS) to define the ore-forming process at Terranera. We show that in this location the fault is made of four levels of mineralized fault rocks having distinct mineral compositions. In these levels, a mineral association made of diopside, clinozoisite, and other Mg-rich minerals is replaced by magnetite, hematite, pyrite, Mg-hornblende, clinochlore, and other Mg-rich phyllosilicates. This paragenesis is overprinted by goethite and clay minerals. Chlorite-quartz geothermometry and fluid inclusion microthermometry show that ore precipitation occurred at 350–180 °C from fluids of distinct bulk salinities, but goethite and clay mineral overprinting progressed at lower T.
We propose that Terranera is a magnesian Fe skarn formed due to the interaction between distinct hydrothermal fluids and a dolomitic protolith, which was preserved within the fault zone. These fluids mixed and cooled during protolith metasomatism, causing ore precipitation due to oxidation and desulfidation. A very similar process was described in a large deposit of Elba (Rio Marina). Argillic alteration was widespread within the fault but met permanently intermediate sulfidation conditions. Trace element composition of hematite shows that Terranera has features that overlap those of skarn and epithermal deposits. In particular, elements that are typical of epithermal deposits (Sb, Ga, Ge, As) occur at mass fractions (50–200 μg/g) that are either unreported or not typical of hematite from skarn deposits. These features identify Terranera as formed in an ore environment that was transitional between that of a skarn and of an epithermal deposit. These features are shared by other historical deposits located at Elba and in the massive pyritic ore district of south Tuscany (e.g., Gavorrano, Fenice Capanne). This indicates that a similar environment might have occurred during the Neogene beyond Elba, in a much larger ore district of south Tuscany
What do recent developments in the area of self-compassion have to offer the treatment of social anxiety?
No full textA variety of recent literature has considered the impact of self-compassion onmental health. Further research is needed, but the evidence to date suggeststhat self-compassion is associated with psychological well-being (Neff, 2003a;Neff, Kirkpatrick, Rude, 2007; Neff, Rude, Kirkpatrick, 2007), and that enhancingself-compassion can buffer against social-evaluative concerns (Leary, Tate,Allen, & Adams, 2007, Neff, 2003a). Additionally, when enhancing selfcompassionas been used as part of a treatment for mental health problems,symptoms have reduced (Gilbert & Procter, 2006; Linehan, Heard, & Armstrong;1999; Lee, 2005; Mayhew & Gilbert, 2008; Teasdale, Segal, Williams,Ridgeway, Soulsby, & Lau, 2000). The following paper explores the role thatself-compassion may have in the aetiology and maintenance of social phobia. Inorder to do this, current aetiological and maintenance models are reviewed, andhypotheses made about how self-compassion may impact on these processes.Evidence from both clinical and nonclinical studies is used to support thesehypotheses, and further research is suggested.In the second paper some of these hypotheses are tested. In this study,evaluations of performance, post-event processing, and anxiety were measuredin a socially anxious analogue group, following a stressful social situation. Thesescores were then compared to those of other socially anxious participants whodid not undergo a self-compassion induction. Results showed no differences inlevels of post-event processing or anxiety between the groups. However,participants in the self-compassion group rated their performance more closelyto the rating of an independent observer than participants in the other groups.This suggests that increasing self-compassion facilitated greater objectivitywhen evaluating participants? own performances of a socially stressful task.Implications for the treatment of social phobia are discussed, and suggestionsare made for further research
Perdita trifasciata Timberlake
No full text<i>Perdita trifasciata</i> Timberlake <p>Figs. 10 C, 11C, 12C, 14C, 23R, 24T, 43B, 48, 57E, 60E–F</p> <p> <i>Perdita trifasciata</i> Timberlake, 1953: 969, ♂; Timberlake, 1954: 370, ♀. Holotype ♂ (SEMC, accession no. SEMC 1111156), White Sands, New Mexico, USA.</p> <p> <i>Perdita</i> (<i>Heteroperdita</i>) <i>trifasciata</i>; Timberlake, 1954: 370.</p> <p> <b>Diagnosis.</b> Both sexes of <i>P. trifasciata</i> have the metasoma dark brown or black with white bands apically on the discs of the terga (Figs. 10 C, 11C). Particularly in the males, the white bands can be interrupted and split into two or four separate marks. The female is similar in coloration to <i>P. sexfasciata</i> and <i>P. optiva</i>, and can be separated from those species by the metasoma with fewer bands (four vs. five), the second medial cell weakened/absent (e.g. Fig. 4 C), mandibles simple, and the pygidial plate narrowly spatulate (24T). The male is distinctive in having only the first three terga with light bands (rarely extending to the fourth tergum). It can be further recognized by the pygidial plate with the apex shallowly and broadly notched (Fig. 23 R), clypeus strongly dentate, and omaulus lacking a weak carina.</p> <p> <b>Redescription of female.</b> Length: 3.2 mm. Forewing length: 2.0 mm.</p> <p> <i>Coloration.</i> Head (Fig. 13 C) and mesosoma base color black with metallic bluish luster; clypeus variably marked, ranging from completely white to black with white limited to lateral margins and medial vertical band; supraclypeal mark ranging from completely dark to small white spot; paraocular mark white, transverse to subtriangular, extending to level of bottom of antennal socket; mandible white, tip brown; labrum variably marked, ranging from all white to dark with white around edges; scape light brown anteriorly, lightened to more or less white posteriorly; antenna brown, more or less white ventrally; pronotal collar with pair of transverse white lateral marks dorso-posteriorly; pronotal lobe more or less white; legs dark brown except white on joints of femora and tibiae, anterior fore tibia, mid basitarsus, and distal fore tarsi; wing veins ranging from light to dark brown; metasoma dark brown except T1–T4 with white bands along margins of discs, bands more or less interrupted by sublateral dark spots (Fig. 11 C); T2 fovea black; pygidial plate brown.</p> <p> <i>Structure and vestiture.</i> Head broader than long (Fig. 13 C); face, except for clypeus and lower supraclypeal area, covered by recumbent white pubescence, pubescence thinner on vertex; eyes subparallel, slightly converging ventrally; facial fovea linear, parallel to eye, extending from level of tops of antennal sockets half distance to apex of eye; mandible simple; labrum quadrate, slightly less than 2X broader than long; disc of clypeus broader than high, convex, apically protruding slightly less than 1 OD from face; lateral extension strongly folded over, not extending towards base of mandible; venter of head with abundant inward-facing broadly hooked hairs; mesosoma strongly tessellate, impunctate, slightly shiny; pronotal collar slightly impressed, humeral angle distinct; mesepisternum and scutum sparsely covered with combination of recumbent and erect white pubescence; fore coxa and anterior venter of mesepisternum with abundant, broadly hooked hairs; apex of mid tibia with some short, thick, curved setae; forewing with second medial cell weakened/absent; metasoma suboval, wide basally, sides more or less parallel, widest at T3 (Fig. 11 C); terga tessellate and impunctate; T2 fovea short, linear, generally less than 1/3 length of T2; pygidial plate narrowly spatulate, apex evenly rounded (Fig. 24 T); hairs of prepygidial fimbria slightly thickened, dense.</p> <p> <b>Redescription of male.</b> Length: 3.1 mm. Forewing length: 1.9 mm.</p> <p> <i>Coloration.</i> Head (Fig. 12 C) and mesosoma base color black with metallic bluish luster; clypeus white, sometimes brown with white restricted to lateral margins and medial vertical band; supraclypeal mark generally absent, sometimes with small white mark; paraocular mark white, transverse or subtriangular, sometimes extending in thin line along eye to level of top of antennal socket; mandible white, tip brownish or reddish; labrum white, sometimes with basomedial dark spot; scape tan except more or less brown anteriorly; antenna brown, tan ventrally; pronotal collar brown, pair of well-separated transverse white marks dorso-posteriorly; pronotal lobe ranging from brown to white; legs dark brown except more or less yellowish-white on anterior fore and mid tibiae and distal fore and mid tarsi, hind legs white at joint of femur and tibia, hind tarsi more or less lightened; wing veins dark brown; metasoma dark brown except T1–T3 with white bands along margins of discs, bands thicker laterally and medially (Fig. 10 C), bands often interrupted, T4 occasionally with vestigial white band; T2 fovea black, obscure; pygidial plate dark brown.</p> <p> <i>Structure and vestiture.</i> Head oval or subquadrate, broader than long (Fig. 12 C); face, except for clypeus and lower supraclypeal area, sparsely covered by recumbent white pubescence; eyes ranging from slightly converging to slightly diverging below; mandible simple, curved inwards, extending to far side of labrum in repose; labrum quadrate, 1.5X broader than long; disc of clypeus broader than high, strongly convex, apically protruding 1 OD from face; lateral dentation relatively prominent, lateral extension reaching 1/3 distance to base of mandible; head with short thickened pubescence ventrally; mesosoma strongly tessellate, impunctate, slightly shiny; pronotal collar slightly impressed, humeral angle weak; mesepisternum and scutum sparsely covered by combination of recumbent and erect white pubescence; hind tibia with sparse, thickened hairs; metasoma equal in width to mesosoma, oval, wide basally, tapering apically, widest at margin of T2/T3 (Fig. 10 C); terga tessellate and impunctate; T2 fovea linear, 1/4 length of T2; pygidial plate short, sides slightly converging, apex broadly truncate, bifid with broad, shallow triangular emargination, lateral tips of apex well-defined (Fig. 23 R); hairs of prepygidial fimbria slightly thickened, sparse.</p> <p> <i>Terminalia</i>. S8 (Fig. 57 E) with spiculum bifurcate; lateral apodemes not prominent, slightly flexed downwards; apical portion strongly convex, slightly longer than broad, sides constricted basally, then bulging out before moderately converging at apex; apex flattened with weak carina medially; short sparse hairs ventrally; cuticle thinned in circle apically. Genital capsule as in Figs. 60 E–F. Gonostyli separated dorsally by narrow Ushape; gonostylus with triangular ventral lobe stacked directly on top of short, squat, dorsal lobe, ventral lobe with few hairs on outer margins of apex; volsella small; cuspis long, narrow with two spicules apically; digitus extremely minute, unornamented; penis valve long, undulating, broadly turned out apically, extending beyond rest of genitalia; endophallus sclerotized with four distinct parallel vertical bands.</p> <p> <b>Floral records. Asteraceae</b> (1 ♀): <i>Psilostrophe tagetina</i> 1 ♀, <b>Boraginaceae</b> (80 ♂ 78 ♀): <i>Heliotropium</i> sp. 1 ♀, <i>Nama havardii</i> 1 ♂, <i>N.</i> sp. 1 ♂, <i>Tiquilia canescens</i> 3 ♂ 1 ♀, <i>T. gossypina</i> 9 ♂ 7 ♀, <i>T. greggii</i> 1 ♂ 2 ♀, <i>T. hispidissima</i> 42 ♂ 43 ♀, <i>T. mexicana</i> 19 ♂ 23 ♀, <i>T.</i> sp. 4 ♂ 1 ♀, <b>Euphorbiaceae</b> (1 ♀): <i>Chamaesyce</i> sp. 1 ♀.</p> <p> <b>Phenology.</b> April to December.</p> <p> <b>Distribution.</b> Chihuahuan Desert (Fig. 43 B), USA and Mexico.</p> <p> <b>Type material examined.</b> Holotype data: ♂, <b>NEW MEXICO:</b> White Sands, 27 Jun 1940, R.H. Beamer (SEMC, accession no. SEMC 1111156).</p> <p> <b>Additional material examined.</b> Total specimens: 93 ♂ 125 ♀. <b>MEXICO</b>: Chihuahua: Chihuahua, 118 km N (29.5918 -106.3538): 1 ♂, 29 Aug 1991, T.L. Griswold; Ojinaga, 31 km W (29.4596 -104.7122): 9 ♂ 6 ♀, 28 Aug 1991, T.L. Griswold, <i>Tiquilia gossypina</i>; Ojinaga, 52 km W (29.5567 -104.9558): 5 ♂ 5 ♀, 28 Aug 1991, T.L. Griswold; 1 ♀, 28 Aug 1991, T.L. Griswold, <i>T. gossypina</i>. <b>Coahuila:</b> Cuatro-Cienegas Prot. Area; Site E 3; ~ 13 km SE Cuatrocienegas; gypsum flat with sinkholes (26.87167 -102.01813): 1 ♂, 22 Jul 2010, K. Wright, <i>T. hispidissima</i>; Cuatro-Cienegas Prot. Area; Site F 4; ~ 18 km E Cuatrocienegas; gypsum flat (26.87167 -102.01813): 1 ♀, 14 May 2010, K. Wright, <i>T. hispidissima</i>. <b>NEW MEXICO: Eddy Co.:</b> Cottonwood Springs (32.09573 - 104.46763): 2 ♀, 10 Jun 2010, J.D. Herndon, A. Druk; Lowe Ranch (32.1744 -104.4989): 1 ♂, 1 Jun 2010, J.D. Herndon, A. Druk; 1 ♀, 28 Jul 2011, J.D. Herndon, N. Klass; Main Cave Entrance, 1.5km SSW (32.1638 - 104.44428): 1 ♀, 27 May 2010, J.D. Herndon, A. Druk; 1 ♂, 22 Jun 2011, J.D. Herndon, N. Klass; Rattlesnake Springs (32.10953 -104.47161): 2 ♀, 10 Jun 2010, J.D. Herndon, A. Druk; Seven Rivers, 3 km S (32.5791 - 104.4331): 3 ♂ 1 ♀, 16 May 1989, T.L. Griswold, <i>T. canescens</i>; 1 ♀, 3 Sep 1990, T.L. Griswold, <i>T.</i> sp.; Walnut Canyon; 1.9km SSE Cottonwood Spring (32.191 -104.4007): 1 ♀, 1 Sep 2011, J.D. Herndon; Walnut Canyon; Whites City (32.1781 -104.3819): 1 ♂, 3 Jun 2010, A. Druk, J.D. Herndon; <b>Otero Co.:</b> White Sands National Monument; Site C 2; 10 km SW visitor's center; gypsum outcrop hill; gypsum flats (32.7163 -106.2414): 1 ♂, 4 Aug 2010, D.C. Lightfoot, <i>T. hispidissima</i>; White Sands National Monument; Site D 1; 1.02 km from U.S. 70; near water tower; gypsum outcrop hill (32.778 -106.1584): 1 ♀, 2–7 Aug 2010, K. Wright; White Sands National Monument; Site E 2; ~ 0.18 km SW of Dunes Dr; gypsum dunes; interdune flats (32.7921 -106.2405): 1 ♂, 2–7 Aug 2010, K. Wright. <b>TEXAS: Brewster Co.:</b> Big Bend National Park, Glen Spr. Road, jct Rte. 11 (29.27061 - 103.15089): 1 ♀, 10 Sep 1999, S.E. Wallace; Big Bend National Park, Hot Springs (29.1819 -102.9917): 1 ♂, 14 Apr 1986, T.L. Griswold, <i>Nama</i> sp.; Big Bend National Park, Nine Pt. Draw(29.6561 -103.0994): 28 ♀, 5 Sep 1999, S.E. Wallace; Lajitas, 2 mi E (29.276 -103.745): 1 ♂, 14 Sep 2004, J.L. Neff, <i>T. hispidissima</i>; Lajitas, 5 mi E (29.283 -103.704): 1 ♂, 9 Sep 1999, J.L. Neff, <i>T. greggii</i>; 7 ♂ 13 ♀, 9 Sep 1999, J.L. Neff, <i>T. mexicana</i>; 2 ♀, 29 Sep 1999, J.L. Neff, <i>T. greggii</i>; 1 ♀, 29 Sep 1999, J.L. Neff, <i>T. mexicana</i>; Study Butte, W edge (29.327 -103.558): 3 ♂ 3 ♀, 19 Apr 2015, J.L. Neff, <i>T. mexicana</i>; <b>Culberson Co.:</b> Linda Lake Salt Basin, Along Rd to dune area (31.81346 -105.08996): 4 ♂, 22 Aug 2010, T.L. Griswold, <i>T.</i> sp.; <b>Hudspeth Co.:</b> Indio Mountains Research Station, 25 km S Van Horn (30.77699 -105.01623): 1 ♀, 25 Aug 1992, W.P. Mackay; 1 ♀, 29 Dec 1992, W.P. Mackay; Salt Flat, 1.5 mi E (31.748 -105.051): 6 ♂ 2 ♀, 14 Jun 2005, J.L. Neff, <i>T. hispidissima</i>; 1 ♂ 4 ♀, 1 Sep 2010, J.L. Neff, A. Hook, <i>T. hispidissima</i>; <b>Presidio Co.:</b> Presidio, 7 mi S (29.449 -104.28): 1 ♀, 16 Oct 1998, R.L. Minckley, <i>Chamaesyce</i> sp.; Redford (29.4497 -104.1889): 1 ♂, 16 Oct 1998, R.L. Minckley, <i>N. havardii</i>; Ruidosa, 8 mi SE (29.891 -104.643): 8 ♂ 16 ♀, 15 Sep 2004, J.L. Neff, <i>T. hispidissima</i>; <b>Reeves Co.:</b> Pecos, 3 mi SE (31.244 -103.349): 1 ♀, 13 Jun 2005, J.L. Neff, A. Hook, <i>Psilostrophe tagetina</i>; 13 ♂ 17 ♀, 13 Jun 2005, J.L. Neff, A. Hook, <i>T. hispidissima</i>; <b>Terrell Co.:</b> Dryden, 17 mi E (29.9038 -101.8716): 2 ♂ 1 ♀, 22 Aug 2008, J.L. Neff, <i>T. mexicana</i>; Dryden, 2 mi N (30.071 -102.104): 1 ♀, 9 Sep 2012, J.L. Neff, <i>T. mexicana</i>; Dryden, 20 mi E(29.9016 - 101.8378): 1 ♀, 22 Aug 2008, J.L. Neff, <i>Heliotropium</i> sp.; 5 ♂ 1 ♀, 22 Aug 2008, J.L. Neff, <i>T. mexicana</i>; Dryden, 24 mi E (29.9008 -101.7844): 1 ♂ 1 ♀, 15 Aug 2008, J.L. Neff, <i>T. mexicana</i>; Dryden, 8 mi SE (29.9732 - 102.0173): 3 ♂ 1 ♀, 28 Aug 1974, G.E. Bohart, W.J. Hanson; Dryden, 9 mi N (30.099 -102.089): 1 ♂ 2 ♀, 12 Aug 2010, J.L. Neff, <i>T. mexicana</i>; <b>Winkler Co.:</b> Kermit, 13 mi S (31.665 -103.016): 11 ♂ 3 ♀, 15 Jun 2005, J.L. Neff, A. Hook, <i>T. hispidissima</i>.</p> <p> <b>Remarks.</b> The male typically has three white bands on the metasoma, but specimens from the more southern localities tend to have four bands.</p>Published as part of <i>Portman, Zachary M., Neff, John L. & Griswold, Terry, 2016, Taxonomic revision of Perdita subgenus Heteroperdita Timberlake (Hymenoptera: Andrenidae), with descriptions of two ant-like males, pp. 1-97 in Zootaxa 4214 (1)</i> on pages 81-83, DOI: 10.11646/zootaxa.4214.1.1, <a href="http://zenodo.org/record/253086">http://zenodo.org/record/253086</a>
THE EFFECT OF MECHANICAL ANHARMONICITY ON THE TEMPERATURE DEPENDENCE OF INTEGRATED INTENSITIES OF SOME METALLIC-PHTHALOCYANINES AND INORGANIC IONS ISOLATED IN ALKALI-HALIDE MATRICES.
No full textAuthor Institution: Department of Chemistry Kent, State UniversityThe expression for the integrated intensity of a fundamental infrared absorption band, including the effects of spontaneous emission and mechanical anharmonicity, has been derived utilizing first-order, non-degenerate perturbation theory. We have studied the temperature effect ( to ) on band intensity in two types of systems; molecular crystals (metallic-phthalocyanines, copper, cobalt and vanadium) and inorganic ions and isolated in alkalihalide lattices. Expressions utilizing the harmonic potential function have also been derived for certain overtones and combinations. These expresions compare favorably with the experimental data. We have also been able, through an intensity study, to identify a librational-rotational transition for the perchlorate system at approximately
Changes in LDL-C levels and goal attainment associated with addition of ezetimibe to simvastatin, atorvastatin, or rosuvastatin compared with titrating statin monotherapy
No full textJoAnne M Foody,1 Peter P Toth,2 Joanne E Tomassini,3 Shiva Sajjan,3 Dena R Ramey,3 David Neff,3 Andrew M Tershakovec,3 Henry Hu,3 Kaan Tunceli31Brigham and Women's Hospital, Boston, MA, 2CGH Medical Center, Sterling, IL, and University of Illinois College of Medicine, Peoria, IL, 3Merck & Co., Inc., Whitehouse Station, NJ, USABackground: Many high-risk coronary heart disease (CHD) patients on statin monotherapy do not achieve guideline-recommended low-density lipoprotein cholesterol (LDL-C) goals, and combination lipid-lowering therapy may be considered for these individuals. The effect of adding ezetimibe to simvastatin, atorvastatin, or rosuvastatin therapy versus titrating these statins on LDL-C changes and goal attainment in CHD or CHD risk-equivalent patients was assessed in a large, managed-care database in the US.Methods: Eligible patients (n = 17,830), initially on statin monotherapy who were ≥18 years with baseline and follow-up LDL-C values, no concomitant use of other lipid-lowering therapy, and on lipid-lowering therapy for ≥42 days, were identified between November 1, 2002 and September 30, 2009. The percent change from baseline in LDL-C levels and the odds ratios for attainment of LDL-C <1.8 and <2.6 mmol/L (70 and 100 mg/dL) were estimated using an analysis of covariance and logistic regression, respectively, adjusted for various baseline factors.Results: LDL-C reductions from baseline and goal attainment improved substantially in patients treated with ezetimibe added onto simvastatin, atorvastatin, or rosuvastatin therapy (n = 2,312) versus those (n = 13,053) who titrated these statins. In multivariable models, percent change from baseline in LDL-C was -13.1% to -14.8% greater for those who added ezetimibe onto simvastatin, atorvastatin, or rosuvastatin versus those who titrated. The odds of attaining LDL-C <1.8 and <2.6 mmol/L (70 and 100 mg/dL) increased by 2.6–3.2-fold and 2.5–3.1-fold, respectively, in patients who added ezetimibe onto simvastatin, atorvastatin, or rosuvastatin versus titrating statins.Conclusion: CHD/CHD risk-equivalent patients in a large US managed-care database, who added ezetimibe onto simvastatin, atorvastatin, or rosuvastatin, had greater LDL-C reductions and goal attainment than those who uptitrated these statin therapies. Our study suggests that high-risk CHD patients in need of more intensive LDL-C lowering therapy may benefit by adding ezetimibe onto statin therapy.Keywords: low-density lipoprotein cholesterol goal, ezetimibe, atorvastatin, rosuvastati
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