549,193 research outputs found
Influence of hydroxyethyl starch (6% HES 130/0.4) administration on hematology and clinical chemistry parameters
No full textBackground: The chemical inertness of hydroxyethyl starch (HES) might cause interferences of the colloid with a variety of laboratory tests. We aimed to evaluate potential influences of HES 130/0.4, the newest HES type, on several common hematology and clinical chemistry parameters. Methods and results: A convenient sample of 25 patients scheduled for rheological therapy with 500 mL 6% HES 130/0.4 was evaluated. Blood samples were drawn before and after colloid application. Comparing pre- and post-infusion values of a battery of laboratory tests (i.e., hematology and hemostasis parameters, electrolytes, enzymes, kidney and metabolic parameters, lipids, etc.) in time course, a median difference greater than the reference change value for a specific parameter was considered clinically relevant. Among all parameters tested, only serum amylase activity displayed a clinically relevant difference between pre- and post-infusion values (median increase of 85% due to HES administration). By applying in vitro experiments, we demonstrated that serum amylase values obtained in the samples diluted in a 1:1 ratio with HES 130/0.4 and in samples diluted in a 1:1 ratio with 0.9% NaCl displayed a negligible median difference of 3%. Conclusions: The in vivo effect of HES 130/0.4 administration on serum amylase activity observed in our study was pharmacological (real) in nature. With the exception of the influence of HES 130/0.4 on amylase activity, the effects of HES 130/0.4 on other parameters tested in this study can be interpreted as having no clinical relevance
hES-RPE differentiation and phenotype of LHX2 knockdown.
No full textExpression of tight junction protein ZO-1 (green) and the transcription regulator MITF (red) in (A) d5 and (B) d14 culture of hES-RPE. Scale bar is 10μm. (C) Gene set enrichment analysis comparing gene expression profiles in differentiated (d14) and de-differentiated (d5) hES-RPE cells shows a significant enrichment for the “RPE gene signature” among the genes up-regulated in d14. (D) The lentiviral transduction of control NS-shRNA or (E) LHX2-shRNA KD to hES-RPE (d14). GFP (green) marks the transduced cells. The indirect immunofluorescent analyses were conducted with antibodies against LHX2 (red, top row), CDH1 (blue, middle row), and OTX2 (purple, lower row). Composite shown on right; adjacent are the separate channels. DAPI (blue) labels the nuclei. Scale bar is 10 μm. (TIF)</p
PSYNDEX Tests Review für HES - Hochheimer Spracheingangsscreening
No full textThis is a PSYNDEX Tests Review of HES - Hochheimer Spracheingangsscreening. PSYNDEX Tests Reviews are written in German and describe and evaluate psychological and educational tests used in the German-speaking countries. PSYNDEX Tests is offered by the Leibniz Institute for Psychology as open access documentation.Das ist ein PSYNDEX Tests Review zu HES - Hochheimer Spracheingangsscreening. PSYNDEX Tests Reviews beschreiben und bewerten zentrale psychologische und pädagogische Testverfahren, die in den deutschsprachigen Ländern eingesetzt werden, nach einem standardisierten Raster. PSYNDEX Tests wird durch das Leibniz-Institut für Psychologie als Open Access Dokumentation angeboten.Diagnostische Zielsetzung: Das HES erfasst den Sprach- und Sprechstand sowie die Lernvoraussetzungen von Kindern zwischen 4 und 8 Jahren bis zum Beginn der 2. Klasse. Die Konzeption des Verfahrens erfolgte für den Einsatz im Rahmen der Schuleingangsdiagnostik. Aufbau: Das Verfahren besteht aus insgesamt 12 Aufgabengruppen aus den Bereichen a) Sprache, b) auditive und visuelle Wahrnehmung, c) Mengenerfassung und d) Motorik: 1) Kommunikation/Blickkontakt/Redeflüssigkeit, 2) Lautbildung, 3) Auditive Wahrnehmung, 4) Prosodie/Stimme/Melodie, 5) Satzbau/Grammatik, 6) Sprachverständnis, 7) Sprech- und Mundmotorik/Luftstrom, 8) Mengenerfassung, 9) Visuelle Wahrnehmung/Augenbewegung/Blickrichtung, 10) Grafomotorik/Augen-Hand-Koordination, 11) Selbstbildnis malen, 12) Körperkoordination/Motorik. Grundlagen und Konstruktion: Die Testkonstruktion, zu der insgesamt relativ wenige Informationen vorliegen, beruht offensichtlich auf der Klassischen Testtheorie. Die Grundlagen des Verfahrens bilden neurobiologische und entwicklungspsychologische Befunde. Bei der Aufgabenauswahl orientierte sich die Autorin an der gängigen Fachliteratur sowie an den Standards für den Förderschwerpunkt Sprache. Empirische Prüfung und Gütekriterien: Reliabilität: Derzeit (April 2018) liegen keine Untersuchungen zur Reliabilität des Verfahrens vor. Validität: Es liegen keine exakten Informationen zur Validität des Verfahrens vor. Jedoch wurde es laut der Testautorin seit 2002 an ca. 500 (HES), 1 200 (HES-K) bzw. 100 (HES-türkisch) Schülern im Rahmen des hessischen Schulanmeldeverfahrens erprobt (Reisz, 2014b, S. 38 f.). Die Ergebnisse hätten sich zu 90% im Schulalltag bestätigt. Normen: Derzeit (April 2018) liegen keine Normen vor.publishedVersio
[The Lymphoid Variant of HES (L-HES) as Differential Diagnose of Severe Asthma in Childhood].
No full textBased on a case report an overview on the differential diagnostic considerations with respect to blood hypereosinophilia (HE) and hypereosinophilic syndromes (HES) in childhood is given. A 13-year-old boy was admitted for the clarification of an asthma. In the blood count an increased HE with 3 500/µl (30%) was found along with elevated total serum IgE and IL-5 level (2 000 IU/ml and 17 pg/ml). Lung function showed an obstruction (FEV1 38%). Radiologically the picture of bronchiectasis and mucus pluggine appeared. In the BAL a HE (76%) with raised IL-5 level was apparent. Histologically asthma was diagnosed with mucostasis, hypertrophy of the bronchial wall musculature and a lung HE. Differential-diagnostically an ABPA, a Churg-Strauss-Syndrome, a parasitosis, drug associated HE, allergies and malignant disease could be excluded. An aberrant T-cell clone in peripheral blood was detected by flow cytometry and T-cell receptor clonal rearrangements by PCR, leading to the diagnosis of a lymphoid variant of HES (L-HES). Failure to detect the FIP1L1-PDGFRA gene fusion and a normal bone marrow examination could exclude a neoplastic HES (HESN). After steroid initiation, prompt decrease of blood eosinophilia with resolution of symptoms was observed. Steroid discontinuation led to eosinophilia recurrence associated with disease symptoms. As steroid-sparing agent the immunosuppressive azathioprine was additionally given; steroid doses could be decreased and stopped in the course. This case demonstrated the range of HE evaluation in infancy. With asthma one should also consider the possibility of a L-HES
Behavior of Air Bubble Screens (HES 33)
No full textnot peer reviewedSubmitted by Nils Oberg ([email protected]) on 2009-06-15T18:34:45Z
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HES-033.pdf: 27809640 bytes, checksum: ce87475eb7b294296ca0f152cd215f03 (MD5)Made available in DSpace on 2009-06-15T18:34:45Z (GMT). No. of bitstreams: 1
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Previous issue date: 1978-09National Science Foundation Grant ENG-76-24226unpublishe
Repair concrete structures with high-early-strength engineered cementitious composites (HES-ECC): Material design and interfacial behavior
No full textAimed at realizing the effective strengthening and durable repair of concrete structures, particularly in emergencies like traffic interruption triggered by broken roads and damaged bridges, nine groups of specimens were designed and tested in this paper to develop the high-early-strength Engineered Cementitious Composites (HES-ECC) featured as both high early-strength and superior long-term-deformability. The high-early-strength effect of sulphoaluminate cement, silica fume, and Portland cement on HES-ECC was compared, as well as their influence on the deformation ability of HES-ECC. Moreover, the interfacial behaviors between HES-ECC and existing concrete structure were clarified, considering the effects of interfacial agents, interfacial treatment methods, and interfacial roughness. The results indicate that HES-ECC with 6% silica fume mixed could obtain both the high early-strength and superior long-term-deformability. The flexural strength at 3 h could reach 66.67% of that at 28d. The compressive strength could reach up to 28.7 MPa at 3 h, and the ultimate tensile strain could remain 4.21% at 28d. Cement paste interfacial agent could enhance the chemical adhesive bonding between HES-ECC and existing concrete while polymer modified interfacial agent was incompatible. The increased roughness of chiseled interface was beneficial to both the bearing capacity and the deformation ability. Interfacial shear performance of the grooved interface was scarcely deteriorated even if the roughness decreased by 54.18% compared with the chiseled interface. The recommended interfacial treatment is chiseled interface combined with grooved interface, as well as a thickness of 1–2 mm cement paste interfacial agent. This study provides valuable and credible experimental data for promoting the application of HES-ECC in repairing existing concrete structures in practice.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Concrete Structure
Hes-Kah-Moie & Squaw
No full textPhotograph of Osage Indian Hes-Kah-Moie and a woman. Copyrighted 1906. Post Card, printed c.1918-1922
Hydroxyethylstärke (HES): Start eines europäischen Risikobewertungsverfahrens
No full textHydroxyethylstärke(HES)-haltige Arzneimittel sind kolloidale Volumenersatzmittel, die als Infusionslösungen hauptsächlich zur Therapie und Prophylaxe einer Hypovolämie und zur Volumensubstitution bei Schock angewendet werden. Im Jahr 2012 wurden die Ergebnisse von zwei neuen großen klinischen Studien (6S und CHEST) publiziert, die eine umfassende Neubewertung des Nutzen-Risiko-Verhältnisses der Anwendung HES-haltiger Arzneimittel notwendig machte, da in den Studien eine HES-Anwendung im Vergleich mit der Anwendung kristalloider Infusionslösungen mit höheren Risiken verbunden war. In keiner der Studien ergab sich ein Überlebensvorteil für die Patienten der HES-Gruppe gegenüber den Patienten, die mit kristalloiden Infusionslösungen substituiert worden
waren, während sich andererseits ein nephrotoxisches Risiko für HES-haltige Arzneimittel
zeigte. Aufgrund dieser Ergebnisse initiierte Deutschland auf europäischer Ebene ein Risikoverfahren (Referral Procedure, Article 31 of Directive 2001/83/EC) zur grundlegenden
Überprüfung des Nutzen-Risiko-Verhältnisses von HES-haltigen Infusionslösungen. Bis eine abschließende Beurteilung und Entscheidung des europäischen Bewertungsverfahrens vorliegt, empfiehlt das BfArM, HES bei Patienten mit schwerer Sepsis nicht anzuwenden. Bei intensivmedizinischen Patienten sollten wegen des Risikosignals aus der CHEST-Studie kristalloide Lösungen gegenüber HES aus Gründen der Patientensicherheit bevorzugt angewendet werden, bis eine endgültige Evaluation aller vorliegenden Daten erfolgt ist
Identification of protective antigens following HES immunization.
No full text<p><b>A-B</b>. Day 28 post-challenge worm and fecal egg burdens (d 14, 21, 28) in C57BL/6 mice immunized with native or heat-treated HES. Data pooled from two experiments. Significance determined by ANOVA as indicated. <b>C</b>. Protective antibody targets revealed by immunoprecipitation of biotin-labeled HES by serum antibodies from immunized mice. Immunoprecipitated proteins were separated by pI (range 3–10) and molecular weights (indicated in kDa) and visualized with streptavidin HRP. Blue, red, green and brown circles represent VAL-1, 2, 3 and 4, respectively. Unknown antigens circled black. Sera pooled from 5 HES-vaccinated C57BL/6 mice pre-challenge and representative of two independent experiments. <b>D</b>. Day 28 post-challenge worm burdens from C57BL/6 mice immunized with a combination of VAL-1,-2 and -3, or with HES depleted of these 3 antigens. Data pooled from two experiments. Significance determined by ANOVA <i>Vs</i> PBS/alum. <b>E-F</b>. Immunoprecipitation of biotin-labeled HES antigens with vaccination sera as (C) from mice immunized with VAL-1/2/3 (E), or VAL-1/2/3 depleted HES (F). <b>G</b>. LC-MS/MS identification of antibody targets in mice immunized with VAL-1/2/3-depleted HES, performed on samples of unlabeled HES immunoprecipitated with serum antibodies from these mice. Proteins ranked according to spectral count (“count”). “Unique” represents number of unique peptide sequences in identification, “score” is Mascot score, and emPAI estimated abundance also shown. Highest scoring BLAST homolog with expect values indicated. <b>H</b>. Day 28 post-challenge worm burdens from C57BL/6 mice immunized with HES or HES depleted of VAL-1, -2, -3 and -4. See also <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004676#ppat.1004676.s005" target="_blank">S5 Fig</a>.</p
Culture of hES cells. (
No full text<p>A) Shows colonies of hES cells cultured on monolayers of PA6 mouse cells to induce neural differentiation. (B) NGFR+ derived hES cells after 6 days of co-culture were cultured as monolayers in serum-free N2 medium as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056831#s2" target="_blank">Methods</a>. The cells remain small and exhibit polygonal morphology. (C) NGFR+ derived hES cells are cultured as a monolayer in serum-containing alpha-MEM medium as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056831#s2" target="_blank">Methods</a>. The cells form aligned, spindle-shaped confluent monolayers. (D) Pellet from alpha-MEM cultured cells after 2-week culture. Cells are small, tightly packed and difficult to disperse. Bars show 200 µm.</p
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