1,720,982 research outputs found
Evaluation of the Cardiac Toxicity of N-Methyl-Glucamine in Leishmaniotic dogs
No full textN-methyl-glucamine (Glucantime®) is a first line drug used in anti-leishmania treatment. Several side-effects, including cardiac negative effects, have been described in patients treated with this drug. In particular, prolongation of the QT interval, ventricular arrhythmias and sudden death have been reported in humans. The aim of this study was to assess the possible negative cardiac effects of N-methyl-glucamine in dogs with spontaneous Leishmaniosis.
Thirteen dogs naturally affected by Leishmaniosis were treated with Glucantime® at a dose of 75 mg/kg q12 h SC for 60 days. On each dog, evaluation of serum cardiac troponin I (cTnI) concentration was carried out using an automated immunoassay method before the onset of the therapy (T0) and at the end of treatment (T60). Furthermore, 24-hour ambulatory electrocardiographic (ECG) monitoring was performed at the same time interval and the QT interval corrected for heart rate (QTc) was calculated using a one-parameter logarithmic formula. Serum cTnI concentration and QTc values at T0 and T60 were compared using a Mann-Whitney u-test and a paired Student’s t-test, respectively. A value of P<0,05 was considered to be significant.
Serum cTnI concentrations were normal either before and at the end of the study and no statistical differences were observed from T0 and T60. No cardiac arrhythmia was found in 24-hour ECG tracings before and after the treatment. Analysis of QTc values did not evidenced any statistical difference from T0 and T60.
Results of the present study evidenced no laboratory and electrocardiographic features of cardiac toxicity in Leishmaniotic dogs treated with a therapeutic dose of N-methyl-glucamine for 60 days
Un caso di Lupus Erytematosus Sistemico in un puledro
No full textUn cavallo da trotto femmina di 2 anni veniva portato alla vista per febbre, anoressia, perdita di peso e dermatite desquamativa diffusa. Il cavallo sviluppava lesioni ulcerative agli arti e petecchie linguali. Si osservava agglutinazione spontanea del sangue. Il cavallo presentava neutrofilia matura e linfopenia moderata. Si evidenziavano incremento della bilirubinemia, proteinuria e riduzione di antitrombina 3. ANA test era 1:40. Biopsie cutanee multiple rilevavano una dermatite da interfaccia povera di cellule.
Le lesioni erano tutte consistenti con una forma di lupus sistemico. Le lesioni cutanee osservate sono molto rare nel cavallo a differenza del pemfigo
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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