6,961 research outputs found

    Teorie e fatti economici / Augusto Graziani

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    Teorie e fatti economici / Augusto Graziani Torino : Fratelli Bocca, 1912 499 p. ; 21 c

    Portrait of Guido Graziani (c. 1965)

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    A portrait photograph of Guido Graziani from c. 1965. Graziani is wearing a suit jacket, tie, and white shirt. He has a neutral facial expression. The back of the photograph has a description that it was taken 25 years ago.Guido Graziani was born in Rome in 1896 and went to Niagara University. He came to the United States to study physical education and psychology at Springfield College and graduated in 1922. He taughts the Italian armed forces sports during World War I and founded the YMCA in Rome in 1919. He organized the first basketball coaching courses in Italy and became one of the Italian Basketball teams coaches in 1936

    Eugenia Graziani Camillucci

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    The headword explains the biography and the contribution of the author Eugenia Graziani Camillucci to the children's literatur

    Portrait of Guido Graziani in baseball uniform (c. 1970)

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    A portrait photograph of Guido Graziani in a basesball uniform from c. 1970. Graziani is wearing the Olympic baseball sweatshirt from 1936 and a baseball hat. He is standing on a field holding two baseballs.Guido Graziani was born in Rome in 1896 and went to Niagara University. He came to the United States to study physical education and psychology at Springfield College and graduated in 1922. He taught the Italian armed forces sports during World War I and founded the YMCA in Rome in 1919. He organized the first basketball coaching courses in Italy and became one of the Italian Basketball teams coaches in 1936

    Clinical perspectives of PARP inhibitors

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    Poly(ADP-ribose) polymerase (PARP) activation plays a role in the pathogenesis of various cardiovascular and inflammatory diseases. At the same time, PARP activation is also relevant for the ability of cells to repair injured DNA. Thus, depending on the circumstances, pharmacological inhibitors of PARP may be able to attenuate ischemic and inflammatory cell and organ injury or may be able to enhance the cytotoxicity of antitumor agents. Both aspects of the "double-edged sword" role of PARP can be exploited for the experimental therapy of disease. As several classes of PARP inhibitors move towards clinical development, or have already entered the stage of clinical trials, we expect that in the upcoming few years, clinical proof of PARP inhibitors' therapeutic effect will be obtained in human disease. In the current short overview, we summarize the pros and cons and challenges with respect to the clinical use of PARP inhibitors, the expected clinical outcomes and potential risks. It appears that on the cytoprotective aspect of PARP, acute, life-threatening diseases (myocardial infarction, cardiopulmonary bypass in high-risk patients, and other, severe forms of ischemia-reperfusion to other organs including stroke and thoracoabdominal aneurysm repair) may represent some of the prime development indications. In the context of inhibition of DNA repair, combination of PARP inhibitors with certain antitumor agents (for example temozolomide) in patients with tumors with extremely poor prognosis are expected to provide the initial clinical results. Development of PARP inhibitors for additional indications (e.g. chronic use for the therapy of neurodegeneration and neuroinflammation, or diabetic complications) may be more challenging because of the unknown potential long-term side effects of PARP inhibitors. (c) 2005 Elsevier Ltd. All rights reserved

    GRAZIANI, C. (2023). Sicurezza e diritti in tempi di terrorismo internazionale. Tra endiadi e antitesi. Nápoles: Editoriale Scientifica

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    Recensión de la obra GRAZIANI, C. (2023). Sicurezza e diritti in tempi di terrorismo internazionale. Tra endiadi e antitesi. Nápoles: Editoriale Scientifica
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