844 research outputs found
Diritto allo studio delle persone con disabilità
No full textIl volume esamina nei suoi vari aspetti la legge quadro per l'assistenza, l'integrazione sociale e i diritti delle persone con disabilità, n.104/1992, che ha inciso e incide tutt'ora in modo assai significativo sul panorama socio-sanitario italiano. In tale contesto analizza la portata pedagogica degli artt-13-17 che specificatamente supera il concetto delle cosiddette "classi differenziali", definendo invece la necessità di realizzare una reale integrazione scolastica in tutti gli ordini e gradi di scuola, e rappresentando, proprio per questo, una disciplina fra le più avanzate al mondo
Ricerca educativa, politiche di istruzione e formazione, e scuola: nuove prospettive dal Rapporto Delors
No full textThis paper debates about the educational goals’ redefinition by through the dialectical relationship between educational research, education and training policies, and school. A reflection on the “four pillars” of learning is currently very important (UNESCO, 1996) starting from the critical analysis of the Delors Report, to re-enable it for the growing and diversified needs of the world of education.In this context, the author discusses some relevant issues about the virtues learning that urges the school and the family to a synergistic and proactive dialogue, and to consciously take educational co-responsibility (Miur, 2006).This dialogue represents the cultural, social and ethical background for “learning to live together”, “to learn to know” and ultimately to “learn to learn” (Recommendation of the European Parliament and of the Council, 2006).In this perspective, the present contribution intends to emphasize the priority of creating inclusive learning contexts that will enhance the individual potential for a school aimed at the development of social cohesion and human capacities.Il presente lavoro discute la ridefinizione degli obiettivi dell’educazione attraverso la relazione dialettica tra ricerca educativa, politiche di istruzione e formazione, e scuola.È attualmente indispensabile, infatti, una rinnovata riflessione relativa ai “quattro pilastri” dell’apprendimento (UNESCO, 1996), mediante un’analisi critica del Rapporto Delors, tale da verificarne la riattualizzazione in vista delle crescenti e diversificate esigenze del mondo dell’educazione. Vengono discusse, in questa sede, alcune questioni rilevanti, in particolare,in merito all’ “insegnamento dei valori”, che sollecita la scuola e la famiglia ad un dialogo sinergico e proattivo, e ad assumere consapevolmente la corresponsabilità educativa (Miur, 2006). Tale dialogo rappresenta lo sfondo culturale, sociale ed etico per “imparare a vivere insieme”, per “imparare a conoscere” e, in definitiva, per “imparare ad imparare” (Raccomandazione del Parlamento e del Consiglio Europeo, 2006). In questa prospettiva, il presente contributo intende sottolineare la priorità di realizzare contesti inclusivi di apprendimento in grado di valorizzare le potenzialità individuali per una scuola finalizzata allo sviluppo della coesione sociale e della capacitazione umana
KMT2C modulates migration and invasion processes in osteosarcoma cell lines
No full textIn this study we investigated the role of KMT2C (a chromatin-modifying and remodelling protein) in osteosarcoma progression through cell migration and invasion assays in osteosarcoma primary and metastatic cell lines. Wound healing and transwell assays were used to detect changes of cell migration and matrigel assay was used to evaluate changes of cell invasion in primary and metastatic osteosarcoma cell lines after KMT2C siRNA transfection. We found that primary osteosarcoma cell lines showed the highest capacity of migration before mRNA KMT2C silencing and the highest capacity of invasion after mRNA KMT2C silencing; on the contrary, osteosarcoma metastatic cell line showed the highest capacity of migration after mRNA KMT2C silencing and the highest capacity of invasion before mRNA KMT2C silencing. Our study supports data in favour of selective enhancer changes, KMT2C-mediated, in metastatic osteosarcoma probably due to the different microenvironment between primary and metastatic sites
Affido familiare e regolazione multilivello: gli interventi regionali nella cornice statale
No full textLevels of soluble endothelial protein C receptor are associated with CD4+ changes in Maraviroc-treated HIV-infected patients.
No full textBackgroundInflammation is a key feature of HIV infection and is correlated with long-term negative cardiovascular outcomes. Therapy-induced increases in CD4(+) cell counts can control inflammation, as shown by decreases of coagulation and inflammation markers during efficacious therapy. Maraviroc, a CCR5-antagonist, has resulted in larger increases in CD4(+) counts both in naïve and experienced subjects compared to traditional antiretroviral therapy.Objectives and methodsTo examine if a member of the protein C anticoagulant and anti-inflammatory pathway, and marker of coagulation and inflammation, the soluble endothelial protein C receptor, is modified by infection and therapy-related variables in patients treated with Maraviroc. Endothelial protein C receptor, together with other established markers of inflammation and coagulation (CRP, IL-6, D-dimer and soluble thrombomodulin) was studied in 43 patients on traditional antiretroviral therapy and in 45 on Maraviroc during 48 weeks of follow-up.ResultsSoluble endothelial protein C receptor was the only marker that could discriminate at least partially between patients with a good response to Maraviroc and patients who did not respond with an adequate increase in CD4(+) cell counts (more than 500 cells/µL by week 48).ConclusionsElevated levels of soluble endothelial protein C receptor, a sensitive marker of endothelial damage, indicated a low level of inflammation and coagulation activation in Maraviroc treated patients not picked up by other widely used markers. Persistent elevated levels of this marker at 48 weeks from beginning of treatment with Maraviroc were related to a poor increase in CD4(+) cells
Correction:Investigation of key performance indicators for performance management of the manufacturing industry in the era of the COVID-19 pandemic (Annals of Operations Research, (2023), 10.1007/s10479-023-05717-4)
No full textDue to typesetting error article was published with missing affiliation of author Charbel Jose Chiappetta Jabbour and needs to be read as: Department of Information Systems, Supply Chain Management and Decision Support, NEOMA Business School, 1 rue du Maréchal Juin - BP 215, 76130 Mont-Saint-Aignan Cedex, France. Original article has been updated.</p
- …
