436 research outputs found
Calcutt, Aubrey C.
No full textBody cremated. Florence Calcutt - wife.https://stars.library.ucf.edu/cfm-ch-memoranda-1926/1492/thumbnail.jp
DS1_JVDI_10.1177_1040638719835243 – Supplemental material for An outbreak of Mycoplasma mycoides subspecies capri arthritis in young goats: a case study
No full textSupplemental material, DS1_JVDI_10.1177_1040638719835243 for An outbreak of Mycoplasma mycoides subspecies capri arthritis in young goats: a case study by Gayle C. Johnson, William H. Fales, Brian M. Shoemake, Pamela R. Adkins, John R. Middleton, Fred Williams, Mike Zinn, W. Jeff Mitchell and Michael J. Calcutt in Journal of Veterinary Diagnostic Investigation</p
Prosaptide prevents paclitaxel neurotoxicity
No full textPaclitaxel (Taxol(TM)), a chemotherapeutic agent used to treat breast and ovarian tumors, has been reported to induce a predominantly sensory neuropathy. Co-treatment with neurotrophic factors and paclitaxel has been proposed for preventing or reversing paclitaxel induced peripheral neuropathy. Prosaposin, the precursor of saposins A, B, C and D was recently identified as a neurotrophic factor and was reported to facilitate nerve regeneration in vivo. Peptides (prosaptides) encompassing the neurotrophic sequence located in the saposin C domain, have neurotrophic activity similar to the holoprotein (O'Brien et al. 1995). In the present study, we investigated the effect of a 14-mer prosaptide, TX14(A), or a 22- merprosaptide, 769P, on paclitaxel-induced neurotoxicity in vitro and in vivo. Paclitaxel treatment (1 μM) decreased cell viability of both PC12 and Schwann cells. TX14(A) (10 nM) prevented paclitaxel-induced loss of cell viability in PC12 cells but not in Schwann cells. Systemic injections (i.p.) of paclitaxel (1.2 mg/kg/day) given five times per week for three weeks (cumulative dose 18 mg/kg) or given every third day (25, 12.5 and 12.5 mg/kg) for 10 ten days (cumulative dose 50 mg/kg) in adult rats induced thermal hypoalgesia that was not accompanied by morphological changes in the sciatic nerve or changes of nerve conduction velocity. Co-administration of paclitaxel with prosaptides (cumulative dose 3 or 10 mg/kg) prevented paclitaxel-induced thermal hypoalgesia. In the short-term high dose study, paclitaxel treated rats lost 10% of their body weight, had reduced erythrocyte counts, hematocrit and hemoglobin concentrations which were not prevented by treatment with prosaptide. TX14(A) did not diminish paclitaxel cytotoxicity of breast cancer cells in vitro. These findings suggest that prosaptide prevents the neurotoxic effects of paclitaxel while not interfering with its anti-tumor activity
Prosaposin-derived peptides enhanced sprouting of sensory neurons in vitro and induced sprouting at motor endplates in vivo
No full textProsaposin exhibits neurotrophic factor properties that are localized to a 12-amino acid sequence located in the amino terminal portion of the saposin C domain. Prosaptides are peptides derived from the neurotrophic portion of prosaposin; these have been previously reported to be bioactive in neuroblastoma cell lines in vitro. We report that prosaptides were also bioactive in explants of adult primary sensory neurons by dose-dependently increasing both the number (3- to 4-fold) and elongation of these neurites by 50%. Local injection of prosaptides into the gluteus muscle of adult mice also induced sprouting at the motor endplate. Our results indicate that prosaptides are potent neuritogenic factors for both sensory and motor neurons of adult peripheral nerve
Variability of CO concentrations in the Venus troposphere from Venus Express/VIRTIS using a Band Ratio Technique
No full textA fast method is presented for deriving the tropospheric CO concentrations in the Venus atmosphere from near-infrared spectra using the night side 2.3 μm window. This is validated using the spectral fitting techniques of Tsang et al. [Tsang, C.C.C., Irwin, P.G.J., Taylor, F.W., Wilson, C.F., Drossart, P., Piccioni, G., de Kok, R., Lee, C., Calcutt, S.B., and the Venus Express/VIRTIS Team, 2008a. Tropospheric carbon monoxide concentrations and variability on Venus with Venus Express/VIRTIS-M observations. J. Geophys. Res. 113, doi: 10.1029/2008JE003089. E00B08] to show that monitoring CO in the deep atmosphere can be done quickly using large numbers of observations, with minimal effect from cloud and temperature variations. The new method is applied to produce some 1450 zonal mean CO profiles using data from the first eighteen months of operation from the Visible and Infrared Thermal Imaging Spectrometer infrared mapping subsystem (VIRTIS-M-IR) on Venus Express. These results show many significant long- and short-term variations from the mean equator-to-pole increasing trend previously found from earlier Earth- and space-based observations, including a possible North-South dichotomy, with interesting implications for the dynamics and chemistry of the lower atmosphere of Venus. © 2009 Elsevier Inc. All rights reserved
A critique of the Securities Regulation Panel's Ability to Enforce Compliance with the Securities Regulation Code
No full textVMI Class of 1904 reunion group, 1909
No full textClass of 1904, Reunion. Members of the Class of 1904 at their 5th reunion, 1909. Image includes Paul L. Borden; Harry C. Calcutt; Ellis C. Caldwell; Paul R. Camp; Bailey T. Clarke; William Couper; James S. Easley; Thomas C. Gordon; Robert L. Harris; Weaver Harris; George W. Headley; William H. Langhorne; William W. LaPrade; William C. McChord; Charles H. Owen; Daniel C. Pearson; Alfred P. Upshur.Condition: Photo broken along bottom quarter
Swinburne Technical College Football Club, 1923
No full textBack Row: L. Grant, C. Small, I. McLaren, J. Bernadou. Middle Row: A. Marshall, G. Wilson, R. McIntyre, C. O'Connor, A. Hulme, K. Park, G. Firth. Front Row: L. Lohse, C. Edwards, S. Tucker, B. Calcutt, A Moreland, S. Russell, L. Philp
Ryhiner-Kartensammlung / 14-17 An actual survey, of the provinces of Bengal, Bahar &c
No full textby Major James Rennell Esq.r engineer, surveyor general, to the honourable the East India Company ; publish'd by permission of the court of directors, from a drawing in their possession; by A. Dury ; W.m Haydon sculp.tWidmung oben rechts: "To John Harrison Esq:r chairman John Roberts Esq:r deputy chairman ..."Nullmeridian: Calcutt
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