23 research outputs found
The synthesis of monodisperse alkanes with long chains
No full textThis thesis discusses reasons for the interest in monodisperse long chain alkanes and describes attempts, past and present, to synthesise such molecules. Chapter 1 discusses why the synthesis of such molecules are important and the objectives of this project. Chapter 2 reviews the methods previous groups have devised to prepare pure samples of long chain alkanes. In particular, work carried out by Whiting et al. at Bristol, whose scheme formed the basis of the early work in Durham. Chapter 3 describes the work in Durham and improvements which were made to Whiting's method, allowing the synthesis of longer chain lengths and greater quantities of materials to be achieved. Chapter 4 provides a summary of the practical work carried out by the author. Chapter 5 gives experimental details of the work described in Chapter 4
ChemInform Abstract: Synthesis of Linear Aliphatic Compounds. Part 3. The Synthesis of Paraffins with Very Long Chains.
No full textThe effect of intra-operative passive movement therapy on non-surgical site pain after breast reconstructive surgery: a preliminary study
No full textPain distant to an operative site is under-reported but sometimes more severe than pain from the surgical site. Intra-operative passive movement could possibly reduce this pain. This preliminary study was designed to assess the practicalities of conducting a randomised controlled trial of this therapy in anaesthetised patients. The study design was pragmatic. Forty-two patients undergoing breast reconstruction were randomly assigned to receive either intra-operative passive movement or standard care. Twenty-four hours after surgery, median (IQR [range]) morphine consumption was 33 (11-42 [0-176]) mg in the passive movement group compared with 74 (15-118 [0-238]) mg with standard care (p = 0.126), while participants reported median (IQR [range]) visual analogue scores in areas distant from the surgical site of 0 (0-4 [0-34]) mm in the passive movement group compared with 10 (2-30 [0-57]) mm in those receiving standard care (p = 0.002). A full trial of intra-operative passive movement therapy to reduce postoperative is feasible and warranted
An IT strategic decision-making framework in the midst of disruptive technologies
No full textThesis (PhD (Informatics))--University of Pretoria, 2020.Technological disruption enabled by the internet revolution has resulted in an exponential
increase in the growth of new technologies and resultant technology disruptions in the workplace.
Many firms do not grasp the new technology trends early enough to improve business processes
and capitalise on these emerging technologies. Over the last five years, there has been
exponential growth of technologies in the consumer space, mainly in social, mobile, collaboration,
big data and cloud-computing technologies. As these technologies mature and gain momentum,
they change the context in which businesses compete and the nature of competition, resulting in
the blurring of the lines between digital and traditional business models across industries.
Disruptive technologies are changing the rules of competition. The rate of change in technology
in the traditional enterprise space has been relatively slow in comparison. Most chief information
officers (CIOs) agree that there could be significant value in utilising new technology in creating a
competitive advantage in an agile world; however, in practice the adoption and implementation of
newer technology occur relatively slowly.
Previous information technology (IT) research predominantly focussed on IT selection, IT risk and
governance, user acceptance of technologies and IT investment criteria. However, there is very
little research on factors influencing strategic IT decisions from a perspective of disruptive
technologies. Business executives would generally invest in IT initiatives that can generate a
return on their investment, grow their business and maintain or create a sustainable competitive
advantage, but organisations are often hesitant to investment in disruptive technologies in agile
business conditions.
The objective of this study was to investigate critical factors that guide strategic IT decisionmaking in an agile business context. This research explored relevant literature on disruptive
technologies, disruptive organisations, approaches to IT decision-making, expectations of CIOs
and enterprise architects in a disruptive context. During literature reviews, various factors were
identified that had an influence on strategic IT decision-making in organisations. These factors
were tested with experienced IT executives who made or influenced strategic IT decisions,
comprising CIOs, enterprise architects, business executives and IT consultants from
organisations across industries. Some of the participants were based internationally or had
gained extensive experience in IT while working for global organisations. The outcome of the data collection resulted in two contributions to the information systems
discipline. The main research contribution is a framework for strategic IT decision-making (FIT
framework) and a step-by-step guide on how this can used by IT decision makers in a disruptive
context. The second research contribution is the BIDD model (business IT, internal IT, digital IT
and digital business), which can be used to classify IT systems based on their functional purpose
in organisations.
The use of the FIT framework and the BIDD model provides CIOs with a comprehensive
guideline to make strategic IT decisions in the midst of disruptive technologies.InformaticsPhD (Informatics)Unrestricte
Multi-candidate immunohistochemical markers to assess radiation response and prognosis in prostate cancer: results from the CHHiP trial of radiotherapy fractionation.
No full textBACKGROUND: Protein markers of cellular proliferation, hypoxia, apoptosis, cell cycle checkpoints, growth factor signalling and inflammation in localised prostate tumours have previously shown prognostic ability. A translational substudy within the CHHiP trial of radiotherapy fractionation evaluated whether these could improve prediction of prognosis and assist treatment stratification following either conventional or hypofractionated radiotherapy. METHODS: Using case:control methodology, patients with biochemical or clinical failure after radiotherapy (BCR) were matched to patients without recurrence according to established prognostic factors (Gleason score, presenting PSA, tumour-stage) and fractionation schedule. Immunohistochemical (IHC) staining of diagnostic biopsy sections was performed and scored for HIF1α, Bcl-2, Ki67, Geminin, p16, p53, p-chk1 and PTEN. Univariable and multivariable conditional logistic regression models, adjusted for matching strata and age, estimated the prognostic value of each IHC biomarker, including interaction terms to determine BCR prediction according to fractionation. FINDINGS: IHC results were available for up to 336 tumours. PTEN, Geminin, mean Ki67 and max Ki67 were prognostic after adjusting for multiple comparisons and were fitted in a multivariable model (n = 212, 106 matched pairs). Here, PTEN and Geminin showed significant prediction of prognosis. No marker predicted BCR according to fractionation. INTERPRETATION: Geminin or Ki67, and PTEN, predicted response to radiotherapy independently of established prognostic factors. These results provide essential independent external validation of previous findings and confirm a role for these markers in treatment stratification. FUNDING: Cancer Research UK (BIDD) grant (A12518), Cancer Research UK (C8262/A7253), Department of Health, Prostate Cancer UK, Movember Foundation, NIHR Biomedical Research Centre at Royal Marsden/ICR
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
No full textPMCID: PMC4636053.-- et al.Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73-75% of identified ccRCC driver aberrations were subclonal confounding estimates of driver mutation prevalence. ITH increased with the number of biopsies analyzed, without evidence of saturation in most tumors. Chromosome 3p loss and VHL aberrations were the only ubiquitous events. The proportion of C>T transitions at CpG sites increased during tumor progression. M-seq permits the temporal resolution of ccRCC evolution and refines mutational signatures occurring during tumor development.C.S. and M. Gerlinger are supported by grants from Cancer Research UK Biomarkers and Imaging Discovery and Development Committee (BIDD), the Medical Research Council and the Seventh European Union Framework Programme, and C.S. is supported by the Breast Cancer Research Foundation and the Rosetrees Trust. We acknowledge the Ramón y Cajal program of the Ministerio de Economía y Competitividad, Spain,
and Novartis for funding support for E-PREDICT clinical trials. This study was
supported by researchers at the National Institute for Health Research Biomedical
Research Centres at University College London Hospitals and at the Royal Marsden Hospital.Peer Reviewe
OS4.8 Improving the intra-operative diagnosis of high-grade glioma using a fluorescence biomarker - A Progress Report of The GALA-BIDD Study
No full textLCSH and PRECIS in library and information science : a comparative study
No full textMade available in DSpace on 2008-03-15T16:30:16Z (GMT). No. of bitstreams: 3
gslisoccasionalpv00000i00194.pdf: 3545205 bytes, checksum: 9af38d944a3c553d6d4647addf04a8d5 (MD5)
gslisoccasionalpv00000i00194_ocr.txt: 149929 bytes, checksum: 6957012b80dca086fead640d4187b859 (MD5)
gslisoccasionalpv00000i00194_tei.xml: 158708 bytes, checksum: afa471710232bc77130fe29f418095ca (MD5)
Previous issue date: 1992Includes bibliographical references (p. 66-68)Compares the performance of LCSH and PRECIS for the books published in 1987 in the field of library and information science in order to investigate the strengths and weaknesses of each system
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No full textLOCALS.
Assemblyman Walter Clark is
in town today.
FOB SALE.
A few choice lots adjo:ning Prof.
! Marx new house on Bryant St.
,_ ,,. _., , , ., . ! Block 25. Choice location, fine
Public School entertainment to-1 yiuw< App|y ftt MiBS MmerS re*
night at Nortree Hall. Be sure and jgidence on Scott St, near Addison
attend. Ave. on same block, or address P.O.
n . __. ._,.._ . box 270 Pulo Alto. MlUpltf
Remember the school children s| .. ,
entertainment at Nortree Hall to- j Robefl and blankets from 1.00 up
night, f *°r l'K' n****- ^,r> d-iys •*■••■ CarrePs.
Contractor M. P. Madison has
completed the Griswold cottage on
Bryant street
Mrs. Chas. Haight, of Stti.taja||d vegetable Market
Clara, is visiting her sister, Mrs. -
Stephens this week. All kinds of Fruit and Vegetables
Mr. Oatiier who has lieen con-1 -n Sea.o.,
nectcd with the Palace Pharmacy I University Avenue Two doors
left Thursday for the north. [ BEL0W THE FAIR pa.0 Alt0.!
Mrs. C. Keene who has been m
visiting her daughter at Alameda! IP
RAMOS & CCw>
^^FRUIT
OurSoap-
ls carefully selected. It is the
best of its kind, all the way
through, from 5c. to $1.00
You want good soap, of course.
We can supply you.
PALACE PHARMACY
•Will Furnish you
We have calls for Houses Furnished and Unfurnished—Bring in your list of Property.
Wanted #1.000, and #1.1.00, to borrow on Palo
Alto Property
Insurance at CUT RATES-c^*"
E. G. DYER & CO.
for the past three weeks is in town.
today. ID
Miss Hat lie Lummis of Chicago,
sister of Charles F. Lummis, is visiting Mr. and Mrs. Frank Cramer
at their home in Mnnzanita Hall.
Bidd were opened this afternoon
for the construction of a 7 room
bouse for J. J. Morris on Bryant
Street adjoining the house occupied
by Professor Hoskins. G. \V.
Mosher was awarded the contract
ELECTRIC LIGHTS
Attorney at Law.
Notary Public
Justice of the Pence
PRESBYTERIAN CHURCH ITEMS
The National Memorial Day will
lm observed at 11 a. m. The
Lighting S
I0l-j)iliiy jj Special rales for residence
Foreatinial-B ami rates apply person-
allv or by letter to
C, Im WOOD vi-MBii
Redwood City.
Branch Olliee, Nortree Hall,
Palo Alto, Cal.
BUY YOUr OIL from the Bysodoir_*yc«MigetairacIeanoUo_
•*' J iiilt strength; a result widen cannot lw
obtalned By any other method of delivering oil as ha. been found bv several
vear. experience of then tank wagons
in I-.ii. tern cities.
G. H. ALLEN Prop
TANK WAGON mm wi,h Tacoma Mil Co.
Order boxes; University P. O. and near P. O. Menlo Park
RED
__________
ESTATE
Thors
IS acres ol land, part Vineyard ami
.art Fruit, with houm* and,
-•am. A tieautiful cypres***-!
pastor's subject will Ih* "Immortal-]avenue. Well fenced. Will'
, ,,, . n mi *ni ! bo sold »t a harimiu. Tbrei
tty of Character.' rhere will be I ,„ii,... from Palo^tdto.
music appropriate to the day.' Two fine bosioou lot. in good location
At S p. m. the pastor will speak on j 'VfUvVf'il.e verv best and cheapest
"The Significance of the Hague Residence lots, inside and
Peace Conference."
STUDIO
MARTEN BUILDING 826 MARKET, Phelan Building
PALO ALTO SAN FRANCISCO
Kodaks developed and printed for amateurs.
Studio at Palo Alto
33. O. To*ornb
<"jjer_t<ir
OPEN EVERY DAY
In.111 :i t.. 10 It.s
or Unfurnished tolet.
Kurn.hc.1
The pastors of Palo Alio have de-; J. B. DALEY, Real ESlale pK"!
cided that each Church would ob-
;iy at 11 a. m.
at their place of worship instead of
" i Tin- I3Aloy ExprewM Oo.
serve Memorial Day at 11 a. ni.b Will haul to or from Sun Jose or Sun
Francisco, Furniture packed, crated or
_. * stored :it reasonable prices.
the 1'nioii Service. iii._.1in •.ttop.o. j.n. wali.y Mm*
JHE PLAZA
Everything new und clean.
Wm. Patrick, Proprietor
-RESTAURANT
Ki.-nt Class Home Cooking
On the Circle, Opp. Depot
LAUMEISTER & DOWNING.
STEAM LAUNDRY
BUILDERS
Estimates on all kinds ol Work. Telephone with Tacoma Mill Co
3=*. o. Sox aoi, np-tio -liio
OF SAX JOSE
Wnsliitin callt-il tor and
Iii-livt-reiI in
I'alo Alto Montlava anil
Friday.
E. C. MOSHER, Agent
Satisfactory Work at Reasonable Rates
MOUROT & CO. ... Redwood City,
Agent. lor Tbe -. Tltotaae Parisian Di ine and Clt-anitli* Work. 27 Tenth
Street, Mm liaticlHco,
New Machinery ami Skilled Labor] Guarantees the
Very Best Work. Wc use an Improved System
of .Marking that guards against loss' of
Articles.
mwwr\wwwwmrwm
CEO, W. IMKMS
PKTKK MULLKN
MULLEM _. HARMS.
Fine Horseshoeing
Spe.ial attention given to Lace G_rtain.jHlgH *"-"-■
asDecialty Carriages
Built and Repaired
Xlopniriii*; JMontly «v 3E**_-O3oei*t>tly 33ono
KET. between l'nivermty and Lytton Avenr Palo Altc
Work called for and delivered
Leave orders at|
Blankets, Table Glotks la*-, brown
AND.GENERAL HOUSEHOLD WORK
fiostier's Billiard Parlor
Cabinet maker
All Kinds of job Carpentering
Repairing at Reasonable Rates High St. near University Av
