894 research outputs found
La narrazione autobiografica come strumento per potenziare il benessere del paziente anziano
No full textNel contributo viene presentato un percorso basato sulla narrazione
autobiografica, progettato per essere somministrato a pazienti anziani
durante la riabilitazione in ospedale dopo un intervento chirurgico per
frattura del femore, al fine di potenziare il loro benessere psicologico e con
l’obiettivo ultimo di impattare positivamente sul recupero funzionale
Characterization of Candida parapsilosis complex strains isolated from invasive fungal infections
No full textIn the present work, we studied the distribution of Candida parapsilosis complex species and the antifungal susceptibility of clinical isolates collected during an Italian surveillance study of yeast invasive fungal infections (IFIs) in intensive care units (ICUs). Minimum inhibitory concentrations (MICs) were determined using the Clinical and Laboratory Standards Institute (CLSI) reference broth microdilution method. BanI digestion patterns of the secondary alcohol dehydrogenase polymerase chain reaction (PCR) products were used to identify C. parapsilosis sensu stricto, C. orthopsilosis, and C. metapsilosis. A total of 138 C. parapsilosis isolates were stored (January 2007-December 2008). The overall frequency of C. parapsilosis complex in IFIs was 22%. Of the 138 tested isolates, 95% were C. parapsilosis sensu stricto, 3.6% were C. orthopsilosis, and 1.4% were C. metapsilosis. The MIC(50) values (expressed as μg/ml) for anidulafungin, caspofungin, and micafungin for C. parapsilosis complex were 2, 1, and 2, respectively, and the MIC(90) values were 4, 2, and 4, respectively. The MIC(50) and MIC(90) values for itraconazole and posaconazole were 0.12 and 0.25, respectively, and for fluconazole, they were 1 and 4, respectively. This study, the most comprehensive study conducted to date to evaluate the frequency and antifungal susceptibility profiles of C. parapsilosis complex isolates from critically ill patients in Italy, highlights the low prevalence of C. orthopsilosis and C. metapsilosis in IFIs
Quadri ormonologici dell' ipotiroidismo in un'area della Repubblica Centro Africana affetta da endemia gozzigena.
No full textMolecular picture of community- and healthcare-associated methicillin-resistant Staphylococcus aureus circulating in a teaching hospital in Milan
No full textThe epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) has dramatically changed over the past 10 y with the emergence of community-associated MRSA (CA-MRSA). Recent studies have reported a frequent association of these strains with hospital outbreaks, and an incidence varying over time and by region. In order to evaluate the MRSA lineages circulating in our area of Italy, we performed a molecular characterization of CA-MRSA isolates prospectively collected from April 2006 to July 2007 at the San Paolo Hospital of Milan. We investigated the protein A-encoding gene (spa-typing), the staphylococcal chromosomal cassette SCCmec, the presence of Panton–Valentine leukocidin (PVL), and 3 adhesin genes. Twenty-five CA-MRSA isolates cultured from 25 patients were collected; an equal number of healthcare-associated (HA)-MRSA strains, from 25 patients hospitalized in various wards, were collected for comparison purposes. SCCmec type IV emerged as the most frequent genotype in both CA- and HA-MRSA. Seventeen different spa types were identified: t515 was the most common (36%), followed by t008 (20%). We detected 3 PVL-positive strains, only among the CA-MRSA. On the whole, our local MRSA epidemiology appears to be heterogeneous, with a predominant t515 spa type, only recently considered to belong to clonal EMRSA-15
Quadri ormonali tiroidei di soggetti gozzuti e non gozzuti osservati in un'area di endemia gozzigena della Repubblica Centro Africana.
No full textNoise Exposure analysis on teachers of the state music conservatory “Nicola Sala” of Benevento City, Italy
No full textFascial manipulation as an adjunct to physiotherapy management in obstetric brachial plexus palsy: A case report
No full textThe integrity of connective tissue sheaths surrounding the nerves influences both the severity and the potential for recovery of brachial plexus lesions. This study presents an innovative, early onset, multidisciplinary approach to obstetric brachial plexus palsy. This approach is aimed at functional recovery of the nerve lesion and includes mobilization of the fascia using the Fascial Manipulation® method. This case study discusses how, in addition to conventional treatment, interventions aimed at the fascial system can potentially affect tension around the neural sheaths, enhance proprioceptive input and facilitate movement to influence obstetric brachial plexus palsy outcomes
STUDY OF CHARMONIUM RESONANCES IN THE GAMGAM -> K0S K+PI- AND GAMGAM -> K+K-PI+PI-PI0 PROCESSES
No full textWe study charmonium resonances produced via two-photon interactions and decaying to the K0S K+ PI- and K+ K- PI+ PI- PI0 final states, using data collected by the BaBar experiment, located at the PEP-II asymmetric e+e- storage ring at SLAC National Accelerator Laboratory.
We observe the eta_c(1S), chi_c0(1P) and
eta_c(2S) resonances produced in two-photon interactions and
decaying to K+ K- PI+ PI- PI0, with significances of 18.1, 5.4 and
5.3 standard deviations (including
systematic errors), respectively, and report 4.0sigma evidence of
the chi_c2(1P) decay to this final state.
We measure the eta_c(2S)mass and width in K0S K+ PI- decays, and
obtain the values m(eta_c(2S))= 3638.5 +/- 1.5 +/- 0.8 MeV/c^2 and
Gamma(eta_c(2S)) = 13.4 +/- 4.6 +/- 3.2 MeV, where
the first uncertainty is statistical and the second is systematic.
We measure the two-photon width times branching
fraction for the reported resonance signals, and search for
the chi_c2(2P) resonance, but no significant signal
is observed
Traslocation of oncogene c-sis from chromosome 22 to chromosome 17 in a human myelogenous leukemia cell line
No full textBy combining somatic cell genetics, in situ hybridization and Southern hybridization, we found that the c-sis oncogene in the human myelogenous leukemia cell line ML3 in translocated from the long arm (q11→qter) of chromosome 22 to the long arm (mid-portion or q21 region) of chromosome 17. This translocation does not result in rearrangement of the c-sis oncogene
The activating form of the CD94 receptor complex. The CD94 associated Kp39 protein represents the product of NKG2-C gene.
No full textInhibitory receptor complexes formed by CD94 and NKG2-A (Kp43) molecules have been implicated in HLA class I recognition by human natural killer (NK) cells. Additional forms of CD94 receptors have recently been described in NK cells characterized by the lack of NKG2-A expression. These CD94 receptors were shown to display activating functions. Immunoprecipitation with anti-CD94 monoclonal antibodies (mAb) led to the identification, in these cells, of a 39-kDa (Kp39) molecule that was originally believed to represent an activating isoform of the CD94 molecules. In the present study we show that the Kp39 molecule is covalently associated with CD94 and displays a protein backbone (26 kDa) similar to that of NKG2-A (Kp43) glycoproteins. Peptide mapping analysis indicates that Kp39 and NKG2-A glycoproteins belong to the same molecular family. A novel NKG2-specific mAb (termed P25) has been generated that specifically reacts with both NKG2-A and NKG2-C molecules, but fails to recognize NKG2-E molecules. Analysis of polyclonal and clonal NK cells shows that P25 mAb reacts with all NKG2-A+ cells and with a fraction of CD94+ cells lacking the expression of NKG2-A. These data indicate that NKG2-C molecules are indeed expressed only in a subset of cells lacking the expression of NKG2-A. The CD94-associated Kp39 molecule can be detected only in NKG2-A- P25+ cells, i.e. cells expressing NKG2-C molecules. Indeed, reverse transcription-polymerase chain reaction analysis performed on a large panel of NK clones indicates that NKG2-A- P25+ NK clones express the NKG2-C transcript. Notably, the cytolytic activity of these clones can be triggered by the P25 mAb in redirected killing analysis. Finally, biochemical analysis of COS7 cells cotransfected with CD94 and NKG2-C demonstrates the identity between Kp39 and NKG2-C molecules. Altogether, our data demonstrate that NKG2-C molecules associate with CD94 to form an activating receptor complex in a subset of human NK cells
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