87 research outputs found
Comparing the efficacy and safety of fixed versus weight-based dosing of epoietin alfa in anemic cancer patients receiving platinum-based chemotherapy
No full textNatural clay and biopolymer-based nanopesticides to control the environmental spread of a soluble herbicide
No full textIn this work a novel nano-formulation is proposed to control leaching and volatilization of a broadly used herbicide, dicamba. Dicamba is subject to significant leaching in soils, due to its marked solubility, and to significant volatilization and vapor drift, with consequent risks for operators and neighbouring crops. Natural, biocompatible, low-cost materials were employed to control its dispersion in the environment: among four tested candidate carriers, a nanosized natural clay (namely, K10 montmorillonite) was selected to adsorb the pesticide, and carboxymethyl cellulose (CMC), a food-grade biodegradable polymer, was employed as a coating agent. The synthesis approach is based on direct adsorption at ambient temperature and pressure, with a subsequent particle coating to increase suspension stability and control pesticide release. The nano-formulation showed a controlled release when diluted to field-relevant concentrations: in tap water, the uncoated K10 released approximately 45% of the total loaded dicamba, and the percentage reduced to less than 30% with coating. CMC also contributed to significantly reduce dicamba losses due to volatilization from treated soils (e.g., in medium sand, 9.3% of dicamba was lost in 24 h from the commercial product, 15.1% from the uncoated nanoformulation, and only 4.5% from the coated one). Moreover, the coated nanoformulation showed a dramatic decrease in mobility in porous media (when injected in a 11.6 cm sand-packed column, 99.3% of the commercial formulation was eluted, compared to 88.4% of the uncoated nanoformulation and only 24.5% of the coated one). Greenhouse tests indicated that the clay-based nanoformulation does not hinder the dicamba efficacy toward target weeds, even though differences were observed depending on the treated species. Despite the small (lab and greenhouse) scale of the tests, these preliminary results suggest a good efficacy of the proposed nanoformulation in controlling the environmental spreading of dicamba, without hindering efficacy toward target species
Randomized phase III study of FOLFOXIRI (irinotecan, oxaliplatin and infusional 5FU/LV) vs FOLFIRI (irinotecan and 5FU/LV) as first-line treatment of metastatic colorectal cancer (MCRC): Subgroup and multivariate analysis
No full textThe role of comprehensive geriatric evaluation (CGE) in the management of older cancer patients.
No full textThe role of comprehensive geriatric evaluation (CGE) in the management of older cancer patient
Suramin/epidoxorubicin association in hormone-refractory prostate cancer: preliminary results of a pilot phase II study.
No full textLong-term outcome of unresectable metastatic colorectal cancer (MCRC) patients (pts) treated with first-line FOLFOXIRI followed by R0 surgical resection of metastases
No full textKRAS and BRAF mutational analyses in a phase II trial of first-line FOLFOXIRI plus bevacizumab (BV) in metastatic colorectal cancer (mCRC) patients (pts)
No full textBiweekly irinotecan, oxaliplatin, and infusional 5-FU/LV (FOLFOXIRI) versus FOLFIRI as first-line treatment of metastatic colorectal cancer (MCRC): Results of a randomized, phase III trial by the Gruppo Oncologico Nord Ovest (G.O.N.O.)
No full textPhase II study of sequential chemotherapy with cisplatin (P) in combination with infusional 5FU/LV (PFL) followed by irinotecan (IR) + 5FU/LV (IrFL) followed by docetaxel (T) + 5FU/LV (TFL) in patients (pts) with metastatic gastric carcinoma (MGC) by the Gruppo Oncologico Nord-Ovest (GONO)
No full textOutcome of initially unresectable metastatic colorectal cancer (MCRC) patients (pts) treated with first-line FOLFOXIRI followed by R0 surgical resection of metastases (mts)
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