85,080 research outputs found
Oral History Interview with Floyd Cox, February 7, 2022
No full textThe National Museum of the Pacific War presents an interview with Floyd C. Cox. He tells of organizing a group of volunteers to establish a formal oral history program. Cox also shares the growth of the program from an unorganized collection of less than 200 oral histories in 1999 to an organized and diversified collection of over 5000 stories in 2022. He tells of the progression from analog tape recordings to digital recordings and the advancement of making the collection available to the public through an online digital archive
A very high density microsatellite map (1 STR/41kb) of 1.7 Mb on Xp22 spanning the microphthalmia with linear skin defects (MLS) syndrome critical region
No full textMicrophthalmia with linear skin defects (MLS) syndrome is an X-linked disorder presenting only in XX individuals. It is characterised by dysmorphic features such as microphthalmia, sclerocornea, and linear streaks of erythematous and hypoplastic skin restricted to the head and neck. Karyotype analyses have so far revealed a terminal deletion or translocation causing monosomy for the distal Xp region (Xp22.3) in all patients. We have used existing cosmid clones from the region to perform a saturation screen for AC-type microsatellites with the goal of facilitating analysis of five novel patients with features of MLS. Three of these cases had an Xp22.3 abnormality, while the other two showed some characteristic features of MLS but had apparently normal karyotypes. Forty-two novel microsatellite markers have now been developed from the 1.7 Mb cloned interval. Ninety-three percent of the novel markers exhibited allelic variation, representing an average of one polymorphic PCR-based marker (STR) every 41 kb.Timothy C Cox, Liza L Cox & Andrea Ballabi
Oral History Interview with Floyd Cox, February 7, 2022
No full textThe National Museum of the Pacific War presents an interview with Floyd Cox concerning his recollections about the Great Depression and his life as a child during World War II. He recalls the family raising a victory garden and his participation in scrap iron drives. He also tells of the patriotism that existed in the United States and of being subjected to various forms of propaganda
Selective COX-2 inhibitors and risk of myocardial infarction
No full textSelective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids. Recently some coxibs, which were designed to exploit the advantageous effects of non- steroidal anti-inflammatory drugs while evading their side effects, have been reported to increase the risk of myocardial infarction and atherothrombotic events. This has led to the withdrawal of rofecoxib from global markets, and warnings have been issued by drug authorities about similar events during the use of celecoxib or valdecoxib/ parecoxib, bringing about questions of an inherent atherothrombotic risk of all coxibs and consequences that should be drawn by health care professionals. These questions need to be addressed in light of the known effects of selective inhibition of COX- 2 on the cardiovascular system. Although COX- 2, in contrast to the cyclooxygenase-1 ( COX- 1) isoform, is regarded as an inducible enzyme that only has a role in pathophysiological processes like pain and inflammation, experimental and clinical studies have shown that COX- 2 is constitutively expressed in tissues like the kidney or vascular endothelium, where it executes important physiological functions. COX- 2- dependent formation of prostanoids not only results in the mediation of pain or inflammatory signals but also in the maintenance of vascular integrity. Especially prostacyclin ( PGI(2)), which exerts vasodilatory and antiplatelet properties, is formed to a significant extent by COX- 2, and its levels are reduced to less than half of normal when COX- 2 is inhibited. This review outlines the rationale for the development of selective COX- 2 inhibitors and the pathophysiological consequences of selective inhibition of COX- 2 with special regard to vasoactive prostaglandins. It describes coxibs that are currently available, evaluates the current knowledge on the risk of atherothrombotic events associated with their intake and critically discusses the consequences that should be drawn from these insights. Copyright (C) 2005 S. Karger AG, Basel
Letter: William C. Cox to Martha Pennino, July 15, 1981
No full textTextual: letter; copy, 11" x 8.5" (29.7 cm x 21.6 cm)Letter from William C. Cox, president of Gulf Oil Realty Company, to Martha Pennino, member of the Fairfax County, Virginia Board of Supervisors for the Centerville District, that is dated July 15, 1981. In this letter, Cox informs Pennino of Gulf’s desire to turn maintenance responsibility for the Lake Anne Dam over to the Reston Home Owners Association. Cox mentions that Gulf was ending its operations in Reston, Virginia, which is a part of Fairfax County, and wanted to expedite the transfer of responsibility. Cox was hoping that Pennino could aide this process, which was being held up because of a resident questioning the safety of the dam. This unnamed resident was requesting that further safety studies of the dam be conducted. This letter marks the beginning of a controversy over the safety of the dams in Reston that would last several years. Planned Community Archives Collection, 006.0
A Note on Implementing Box-Cox Quantile Regression
No full textThe Box-Cox quantile regression model using the two stage method suggested by Chamberlain (1994) and Buchinsky (1995) provides a flexible and numerically attractive extension of linear quantile regression techniques. However, the objective function in stage two of the method may not exists. We suggest a simple modification of the estimator which is easy to implement. The modified estimator is still pn{consistent and we derive its asymptotic distribution. A simulation study confirms that the modified estimator works well in situations, where the original estimator is not well defined. --Box-Cox quantile regression,iterative estimator
Samuel S. Cox portrait
No full textPortrait of Samuel S. Cox, ca. 1890-1899. Cox strongly opposed slavery's expansion into new territory during the 1850s. As an Ohioan, he served in the United States House of Representatives from 1857 to 1865. Cox also served New York as a U.S. representative from 1869 to 1885 and from 1887 to 1889. He died in office in 1889. This cabinet card may have been created after his death as a memorial
[Letter from R. E. Gray to C. C. Cox, October 6, 1896]
No full textLetter from R. E. Gray to C. C. Cox discussing the potential sale of some land and a description of the plot. The envelope is included
Concentration in Knowledge Output: A case of Economics Journals
No full textThis paper assesses the degree of author concentration in seven economics journals, which were published in India during 1990-2002. To measure the degree of author concentration, Lotka's Law was used. Moreover, we also make an exploratory analysis of the geographic, economics subfield and institutional concentration in 704 economics journals. An important finding of this paper is that specialized journals in the sample report the highest degree of author concentration. This result is quite similar to the findings by Cox and Chung (1991). Furthermore, there are several instances showing that the journals lean towards certain norms; this may affect the flow of innovative ideas into economics. We conclude that a knowledge activity, involving the high degree of concentration and a biased publication process, may affect the flow of new ideas into the discipline.Concentration, Lotka's Law
Mary Ann Cox Index: Royal Society Collection
No full textBurton-Wood: in a series of letters, by a lady (Mrs. - Cox nee Wight), London (printed for the author by H.D.Steel) 1783, vol.11
(octovo vol, leather bound)
Enclosed: note The book Burtonwood was written by the mother of
Mary Ann Cox who ran the first coach from Hobart to Launceston.
It was passed on to me by her grand-daughter Miss Dora Clerk of Malahide.
I also am a grand-daughter of Mrs. Cox. Joan Harvey
(John Edward Cox m. Mary Ann Halls
V.D.L. 1821 J.E.C. started Hobart-Launceston coach) - (note - Mrs.
Harvey's identification of the author of the volume was based on family
tradition although not confirmed - no details are known of John Edward
Cox's parents)
Poems by C(harles) Best c 1847 - 1849
Includes poems to Miss Wilmot (Georgiana Wilmot, - Mrs. C. Butler)
and Mary Wilmot.
Enclosed: note by Joan Harvey
Article on Mrs. Mary Ann Cox 1950.
A pioneer career woman (on coach service between Hobart - Launceston)
from "Woman's Day" Aug. 21, 1950 (news clipping)
R.S. 14
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