2,781 research outputs found
Copper-catalyzed CuAAC/intramolecular C–H arylation sequence: Synthesis of annulated 1,2,3-triazoles
No full textStep-economical syntheses of annulated 1,2,3-triazoles were accomplished through copper-catalyzed intramolecular direct arylations in sustainable one-pot reactions. Thus, catalyzed cascade reactions involving [3 + 2]-azide–alkyne cycloadditions (CuAAC) and C–H bond functionalizations provided direct access to fully substituted 1,2,3-triazoles with excellent chemo- and regioselectivities. Likewise, the optimized catalytic system proved applicable to the direct preparation of 1,2-diarylated azoles through a one-pot C–H/N–H arylation reaction
Abdominal fat is dangerous for arteries even in older people.
No full textAbdominal fat is dangerous for arteries even in older peopl
Is vascular stiffness associated with the diameter of the abdominal aorta?
No full textThe aim of this study was to assess the relationship between abdominal aortic diameter, arterial compliance and the traditional cardiovascular risk factors in a group of healthy elderly subjects. In this study we have described the relationships between abdominal aortic diameter and the most important cardiovascular risk factors, showing that arterial compliance plays an important role in explaining, and potentially determining the diameter of the abdominal aorta and may thus be a new index to early recognize people at higher risk of AAA
A phylogenetic reappraisal of Excipulariopsis narsapurensis in Wiesneriomycetaceae, Tubeufiales
No full textParaparath, Sruthi O., Rajkumar, Sakshi, Rajeshkumar, Kunhiraman C., Verma, Rajnish K., Gautam, Ajay Kumar, Narula, Bhavna, Wijayawardene, Nalin N., Tibpromma, Saowaluck, Karunarathna, Samantha C. (2023): A phylogenetic reappraisal of Excipulariopsis narsapurensis in Wiesneriomycetaceae, Tubeufiales. Phytotaxa 607 (5): 273-290, DOI: 10.11646/phytotaxa.607.5.2, URL: http://dx.doi.org/10.11646/phytotaxa.607.5.
-cymene)]
No full textThe well-characterized ruthenium(II) biscarboxylate complex [Ru(O(2)CMes)(2)(p-cymene)] enabled versatile direct (hetero)arylations of C(sp(3))-H bonds with low (co)catalyst loading and ample substrate scope. Detailed mechanistic studies provided strong support for a facile and reversible C(sp(3))-H bond metalation
Irbesartan improves arterial compliance more than lisinopril.
No full textBACKGROUND:
Antihypertensive agents can reduce arterial stiffness. We hypothesized that an angiotensin receptor blocker (ARB) irbesartan and an angiotensin converting enzyme inhibitor (ACEI) lisinopril improved arterial compliance.
METHODS:
A randomized, double-blind, double-dummy, controlled crossover trial. Fifteen hypertensive patients, mean age 65.5 +/- 8.9 years (mean +/- SD) were given irbesartan (150 to 300 mg/day) or lisinopril (10 to 20 mg/day) for 12 weeks and then crossed over for 12 weeks. Pulse wave velocity (PWV) in the carotid-femoral (CF), carotid-radial (CR), and femoral dorsalis-pedis (FD) were measured using a Complior((R)) PWV system.
RESULTS:
After 12 weeks, systolic blood pressure (SBP) decreased from 162.4 +/- 12.9 to 134.5 +/- 14.8 with irbesartan and to 145.2 +/- 25 mmHg with lisinopril. Irbesartan and lisinopril reduced PWV (CF) in the elastic arterial system from 15.1 +/- 5 to 13.3 +/- 2.6 (p < 0.005) and to 14 +/- 4.7 (p < 0.05) m/s respectively (p = 0.345). Irbesartan reduced PWV (CR) and PWV (FD), whereas lisinopril did not. The difference between treatments was significant after SBP adjustment (p = 0.037 for PWV (CR) and p < 0.001 for PWV (FD)).
CONCLUSIONS:
Irbesartan improved arterial compliance in elastic and muscular arteries, whereas lisinopril improved it only in elastic arteries
Arterial compliance may be reduced by ingestion of red wine
No full textThe aim of this study was to assess the effect of alcohol on blood pressure and arterial compliance over 24 h in a group of volunteers, comparing the same group of subjects on two consecutive but separate days, one with alcohol intake (alcohol day) and one free of alcohol (control day). We studied 18 healthy subjects (mean age 34.2 years, range 25-53). The subjects received the two days in random order. On the alcohol day, the subjects were asked to drink two glasses of red wine (12% ethanol) between 1830 hours and 0430 hours. Measurements of heart rate, blood pressure and QKD interval (Q wave to Korotkoff (K) sound, diastolic phase (D) using Diasys Integra (Novacor, France)) were recorded (usually 1500 hours to 1500 hours). Three 'ingestion' periods were defined, from 1500 hours to 1830 hours ('before'), 1900 hours to 0430 hours ('during') and from 0430 hours to the following afternoon ('after') on both the alcohol day and on the control day. Red wine increased heart rate during alcohol ingestion and reduced arterial compliance after ingestion. The significant effect of interaction between day and ingestion period on heart rate, diastolic blood pressure and QKD were found, suggesting that the differences in response among the ingestion periods depended on whether alcohol has been consumed that day. For the first time our study indicates the effect of alcohol on 24 h arterial stiffness in a healthy group of volunteers
is augmentation index a good measure of vascular stiffness in the elderly?
No full textObjectives: we investigated the exact relationship between age and gender on augmentation pressure (AG) and augmentation
index (AI) measured over the radial (muscular) and carotid (elastic) arteries.
Design and Methods: AG is the contribution that wave reflection makes to systolic arterial pressure. AI is an indirect measure of arterial stiffness and is calculated as AG divided by pulse pressure (PP) ×100. AG and AI both increase with age.
AG and AI were measured in 458 subjects using SphygmoCor. A total of 755 readings were obtained (302 carotid, 453 radial).
The mean age was 57.5 ± 13.7 years. Diabetic subjects were excluded. Among the subjects, 13.5% were hypertensive.
Results: statistically, women had mean values of AI significantly higher than men in both radial and carotid arteries. These
differences were less marked with AG.
Quadratic equations better described the relationship between AI and age but not AG and age. Thus, AI increased with age up to our median age of 55 years but plateaued thereafter, whereas the AG continued to increase steadily with age. A multiple regression analysis demonstrated that both AI and AG were negatively related to height and positively related to
diastolic blood pressure (DBP).
Conclusions: AG continues to increase in the elderly over the age of 55, but not AI. AI is higher in women and higher when
measured over the carotid than the radial. AI is positively related to DBP and negatively to height. AG is proposed as a more
suitable measure of arterial stiffness than AI
A study in grid simulation and scheduling
No full textGrid computing is emerging as an essential tool for large scale analysis and problem solving in scientific and business domains. Whilst the idea of stealing unused processor cycles is as old as the Internet, we are still far from reaching a position where many distributed resources can be seamlessly utilised on demand. One major issue preventing this vision is deciding how to effectively manage the remote resources and how to schedule the tasks amongst these resources. This thesis describes an investigation into Grid computing, specifically the problem of Grid scheduling. This complex problem has many unique features making it particularly difficult to solve and as a result many current Grid systems employ simplistic, inefficient solutions. This work describes the development of a simulation tool, G-Sim, which can be used to test the effectiveness of potential Grid scheduling algorithms under realistic operating conditions. This tool is used to analyse the effectiveness of a simple, novel scheduling technique in numerous scenarios. The results are positive and show that it could be applied to current procedures to enhance performance and decrease the negative effect of resource failure. Finally a conversion between the Grid scheduling problem and the classic computing problem SAT is provided. Such a conversion allows for the possibility of applying sophisticated SAT solving procedures to Grid scheduling providing potentially effective solutions
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