4,717 research outputs found
Refined shell elements for the analysis of functionally graded structures
No full textThe present paper considers the static analysis of plates and shells made of Functionally Graded Material (FGM), subjected to mechanical loads. Refined models based on the Carrera's Unified Formulation (CUF) are employed to account for grading material variation in the thickness direction. The governing equations are derived from the Principle of Virtual Displacement (PVD) in order to apply the Finite Element Method (FEM). A nine-nodes shell element with exact cylindrical geometry is considered. The shell can degenerate in the plate element by imposing an infinite radius of curvature. The Mixed Interpolation of Tensorial Components (MITC) technique is extended to the CUF in order to contrast the membrane and shear locking phenomenon. Different thickness ratios and orders of expansion for the displacement field are analyzed. The FEM results are compared with both benchmark solutions from literature and the results obtained using the Navier method that provides the analytical solution for simply-supported structures subjected to sinusoidal pressure loads. The shell element based on refined theories of the CUF turns out to be very efficient and its use is mandatory with respect to the classical models in the study of FGM structures. © 2011 Elsevier Ltd
Experimental and modeling study of the reaction C2F4 (+M) = CF2 + CF2 (+M)
No full textThe thermal dissociation reaction C2F4(+ M) → 2CF2(+ M) was studied in shock waves monitoring CF2 radicals by their UV absorption. The absorption coefficients as functions of wavelength and temperature were redetermined and are represented in analytical form. Dissociation rate constants as functions of bath gas concentration [M] and temperature, from previous and the present work, are presented analytically employing falloff expressions from unimolecular rate theory. Equilibrium constants are determined between 1200 and 1500 K. The data are shown to be consistent, with a C–C bond energy of 67.5 (±0.5) kcal mol–1. High-pressure limiting rate constants for dissociation and recombination are found to be unusually small. This phenomenon can be attributed to an unusually pronounced anisotropy of the potential energy surface, such as demonstrated by quantum-chemical calculations of the potential energy surface.Fil: Cobos, Carlos Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Croce, Adela Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Luther, K.. Universität Göttingen. Institut für Physikalische Chemie; AlemaniaFil: Sölter, L.. Universität Göttingen. Institut für Physikalische Chemie; AlemaniaFil: Tellbach, E.. Universität Göttingen. Institut für Physikalische Chemie; AlemaniaFil: Troe, J.. Universität Göttingen. Institut für Physikalische Chemie; Alemania. Max-Planck-Institut für Biophysikalische Chemie; Alemani
La basilica di Santa Croce. Nuovi contributi per Ravenna tardoantica
No full textRaccolta di saggi dedicati al complesso di Santa Croce e al mausoleo di Galla Placidia in Ravenn
Das ästhetische Element in der historischen Erkenntnis. Croce und Windelband
No full textThe author makes a comparison between Benedetto Croce’s academic
writing of 1893, La storia ridotta sotto il concetto generale dell’arte, and Wilhelm
Windelband’s Rektoratsrede of 1894, Geschichte und Naturwissenschaft. By means
of this comparison, which is focused on the concepts of intuition and interest, the author
can reconstruct the dense network of sources of the theory of the history outlined by the
young Croce and by Windelband: from Lazarus to Simmel, from Köstlin to Labriola
Update of the budget impact analysis of the simplification to atazanavir + ritonavir + lamivudine dual therapy of HIV-positive patients receiving atazanavir-based triple therapies in Italy starting from data of the Atlas-M trial
No full textUmberto Restelli,1,2 Massimiliano Fabbiani,3 Simona Di Giambenedetto,3 Carmela Nappi,4 Davide Croce,1,21Center for Health Economics, Social and Health Care Management, LIUC – Università Cattaneo, Castellanza, Italy; 2School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; 3Institute of Clinical Infectious Diseases, Catholic University of Sacred Heart, 4Health Economics, Bristol Myers Squibb S.r.l., Rome, ItalyIn 2017, the authors published an article to assess the financial consequences for the Italian National Health Service, over a 5-year period, of the adoption of a simplification strategy to atazanavir (ATV) + ritonavir (r) + lamivudine (3TC) dual therapy of HIVpositive patients receiving ATV plus two nucleoside reverse transcriptase inhibitors (NRTIs) starting from data of the Atlas-M trial at 48 weeks.1Consequently to the publication of the clinical results of the Atlas-M trial at 96 weeks, we updated the model implemented for the analysis, considering the most recent evidence.2The model was adapted considering the transitions among antiretroviral therapies (ARTs) observed in the trial, as reported in Figure 1, for years 1 and 2, and maintaining for years 3, 4, and 5 the same differential effectiveness (percentage of patients without virologic failure) observed between 48 and 96 weeks. In detail, the percentage of virologic failures considered in year 1 were 4.51% for ATV+r+2 NRTI and 0.76% for ATV+r+3TC; and in each following year were 8.66% for ATV+r+2 NRTI and 3.05% for ATV+r+3TC
Role of TCL1 and ALL1 in human leukemias and development
No full textWe have investigated the role of chromosomal translocations in the pathogenesis of human leukemias. The study of T-cell chronic lymphocytic leukemias and T-cell prolymphocytic leukemia has led to the identification of TCL1, a novel gene that is deregulated by translocations, t(14;14)(q11;q32), or inversions, inv(14)(q11;q32.1). Introduction of a human TCL1 gene juxtaposed to the lck promoter into fertilized mouse eggs resulted in the development of transgenic mice that developed mature T-cell leukemias, indicating that TCL1 is a transforming oncogene. We have also investigated acute leukemias with abnormalities at chromosome 11q23. We have identified a gene, ALL1, that can fuse to many different genes in acute leukemias. We have also shown that ALL1 can rinse with ALL1 in acute myelogenous leukemia. We have proposed that the ALL1 fusion genes may act by a dominant negative mechanism
Take your "M" time
No full textBoth entry and exit from mitosis are driven through the fine modulation of Cdk1 activity by several proteins or protein complexes. It is well established that to enter into the M-phase a cell requires Cdk1 to be fully activated in the nucleus by the Cdc25A, B and C phosphatases. Then, at the onset of anaphase Cdk1 activity suddenly drops mainly due to Cyclin B1 degradation, thus allowing exit from M-phase. Recent data demonstrate that high Cdk1 activity is necessary also for proper chromosome segregation, since its premature drop determines acceleration of the progression from prophase to metaphase eventually with incorrect division of the DNA content. A primary role in maintaining high Cdk1 activity during prophase and metaphase is played by Cdc25C phosphatase. During the M-phase, the activity of Cdc25C is regulated by the FEZ1/LZTS1 (LZTS1) tumor suppressor gene, which is able to prevent Cdc25C degradation in mitotic cells. As a consequence, Lzts1 absence in mice results in accelerated mitotic progression, improper chromosome segregation and, eventually, in increased incidence of both spontaneous and carcinogen-induced cancer formation. © 2007 Landes Bioscience
Moral Understanding, Testimony, and Moral Exemplarity
No full textWhile possessing moral understanding is agreed to be a core epistemic and moral value, it remains a matter of dispute whether it can be acquired via testimony and whether it involves an ability to engage in moral reasoning. This paper addresses both issues with the aim of contributing to the current debates on moral understanding in moral epistemology and virtue ethics. It is argued that moral epistemologists should stop appealing to the argument from the transmissibility of moral understanding to make a case for their favorite view of moral understanding. It is also argued that proponents of exemplarist moral theories cannot remain neutral on whether the ability to engage in moral reasoning is a necessary component of moral understanding. © 2019, The Author(s)
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