2,555 research outputs found
Disputatio Iuridica De Fideiussione / Quam ... Sub Praesidio ... D. Johannis Godefridi Langenberg/ ICti ... Publicae placidaeq[ue] disquisitioni & censurae subiicit Georgius Fridericus Essenius, Moersensis, Author & Respondens Anno à reparata Salute MDCLXXIV. Die Septembris ...
No full textPre-renal azotemia: A flawed paradigm in critically ill septic patients?
No full textThe term pre-renal azotemia (or on occasion 'pre-renal renal failure') is frequently used in textbooks and in the literature to indicate an acute syndrome characterized by the presence of an increase in the blood concentration of nitrogen waste products (urea and creatinine). This syndrome is assumed to be due to loss of glomerular filtration rate but is not considered to be associated with histopathological renal injury. Thus, the term is used to differentiate 'functional' from 'structural' acute kidney injury (AKI) where structural renal injury is taken to indicate the presence of so-called acute tubular necrosis (ATN). This paradigm is well entrenched in nephrology and medicine. However, growing evidence from experimental animal models, systematic analysis of the human and experimental literature shows that this paradigm is not sustained by sufficient evidence when applied to the syndrome of septic AKI, especially in critically ill patients. In such patients, several assumptions associated with the 'pre-renal azotemia paradigm' are violated. In particular, there is no evidence that ATN is the histopathological substrate of septic AKI, there is no evidence that urine tests can discriminate 'functional' from 'structural' AKI, there is no evidence that any proposed differentiation leads or should lead to different treatments, and there is no evidence that relevant experimentation can resolve these uncertainties. Given that septic AKI of critical illness now accounts for close to 50% of cases of severe AKI in developed countries, these observations call into question the validity and usefulness of the 'pre-renal azotemia paradigm' in AKI in general. Copyright (C) 2007 S. Karger AG, Basel
AMČR - dokument C-TX-194605313
No full textStav: 3Popis: Zpráva o lokalitě. AfV Teplice.Lokalizace akce: Poloha "Langenberg am See", nad samotou.Rok zahájení akce: 0Rok ukončení akce:
The strange history of the bridge over the Adda in Trezzo: from Late Middle Ages Chronicles to Structural Medievalism
No full textNon-rigid cryptic sponges in oyster patch reefs (Lower Kimmeridgian, Langenberg/Oker, Germany)
No full textTwo patch reefs which predominantely consist of the oyster Nanogyra nana (Sowerby 1822) are exposed in Lower Kimmeridigian strata of the Langenberg hillrange, central Germany. Left oyster valves making up the framework of the reefs formed small abundant cavities that were inhabited by a unique sponge community. The excellent preservation of non-rigid sponges was related to early organomineralization within the decaying sponge tissue. As a process of sponge taphonomy, different types of microbially induced carbonates precipitated preserving spicule aggregates. Organomineralization within sponge soft tissues is especially favored within the Langenberg patch reefs due to the closed or semi-closed system conditions within the cavities. The delta (13)C values of in situ formed microbialites reveal that carbonate precipitation was in equilibrium with Jurassic seawater. The carbon of the microbialites does not derive from the bacterial remineralization of organic matter, but is of a marine source. Likewise, organomineralization is probably related to bacterial EPS or decaying sponge tissues providing an organic matrix for initial carbonate precipitation. Biomarker analyses revealed, that the patch reef microbialites contain terminally branched fatty acids (iso- and anteiso- pentadecanoic acid) in significant concentrations. These fatty acids, like hopanoid hydrocarbons, are most likely of a bacterial source. This is in agreement with sulfate-reducing bacteria remineralizing the decaying sponges as further indicated by the occurrence of framboidal pyrite in sponge microbialites
Using subgroup discovery and latent growth curve modeling to identify unusual developmental trajectories
No full textMayer A, Kiefer C, Langenberg B, Lemmerich F. Using subgroup discovery and latent growth curve modeling to identify unusual developmental trajectories. In: Engel U, Quan-Haase A, Liu SX, Lyberg L, eds. Handbook of Computational Social Science, Volume 2. Data Science, Statistical Modelling, and Machine Learning Methods. London: Routledge; 2021: 244-268
Latrine towers. Models, uses and diffusion in Mediterranean architecture from the 12th to the 14th century
No full textSources on the types and uses of latrines in medieval architecture are sporadic and general. Moreover, studies on the subject are rare, unlike those published for the Roman period. The aim of this paper is to study the hygienic spaces in thirteenth-century residences, in particular the latrine towers in curial palaces, analyzing their models and later applications. The historical and typological-architectural context will also be established by means of comparisons with hygienic facilities used in the Islamic context, in Norman and Swabian castles and palaces in southern Italy, in European residential and castral buildings, and in Outremer crusade architecture, with particular attention to that of the Hospitaller Order: the Crac des Chevaliers and the Acre complex. These are two very important testimonies in the development and diffusion of the latrine tower model in Europe, of which the tower of the Pontifical Palace of Viterbo is one of the first examples. The Tower of Viterbo was built during the works commissioned by Pope Clement IV. He was a supporter and admirer of the Hospitallers, with whom he had been in frequent contact. Charles I of Anjou also had close contacts with the Hospitallers, and he was probably responsible for the construction of another latrine tower in the residence of the SS. Quattro Coronati in Rome. The Viterbo tower typology was the model for the similar structure in the Papal Palace in Avignon
Mining Exceptional Mediation Models
No full textLemmerich F, Kiefer C, Langenberg B, Cacho Aboukhalil J, Mayer A. Mining Exceptional Mediation Models. In: Helic D, Leitner G, Stettinger M, Felfernig A, Raś ZW, eds. Foundations of Intelligent Systems. 25th International Symposium, ISMIS 2020, Graz, Austria, September 23–25, 2020, Proceedings. Lecture Notes in Computer Science. Vol 12117. Cham: Springer ; 2020: 318-328
Architects and engineers: design authorship between synergies and disagreements
No full textIn Italia, la realizzazione di strutture complesse come i grattacieli ha richiesto una stretta collaborazione tra architetti e ingegneri, come è emerso già dagli anni Trenta con i primi edifici alti, tra cui la torre progettata a Genova da Marcello Piacentini in collaborazione con l’ingegnere Angelo Invernizzi. Questo rapporto si basava su un fitto scambio di corrispondenza, ricco di riflessioni, schizzi e suggerimenti, che ha influenzato profondamente l’intero processo progettuale. Ancora più nota è stata la sinergia tra Gio Ponti e Pierluigi Nervi, culminata nel 1960 con il grattacielo Pirelli a Milano, un’opera in cui la cultura tecnica non si è limitata ad essere una sfida costruttiva, ma ha assunto un ruolo centrale nella definizione della tipologia del grattacielo e della sua configurazione spaziale e formale. La costruzione di alcuni iconici grattacieli italiani è stata pertanto analizzata ed interpretata sotto una nuova luce, studiando gli scambi epistolari conservati in diversi archivi privati, permettendo di riflettere su temi come l’autorialità, i confini flessibili e le strette collaborazioni tra progettisti architetti e strutturisti ingegneri
Osmoregulation of aldose reductase and sorbitol dehydrogenase in cultivated interstitial cells of rat renal inner medulla
No full textBackground. Little is known about sorbitol metabolism in renal papillary interstitial cells. For characterization we studied regulation of sorbitol synthesis by aldose reductase (AR) and degradation by sorbitol dehydrogenase (SDH) in papillary interstitial cells. Methods. Interstitial cells were isolated from rat renal inner medulla to a pure cell fraction. mRNA was isolated from cultivated cells and sorbitol, AR and SDH activity were determined enzymatically in homogenates. Results. Sorbitol concentration in these cells at 300 mosmol/l was 4.4 +/- 0.3 vs 78 +/- 3.6 mumol/g protein at 600 mosmol/l. At steady-state conditions at 300 mosmol/l, AR activity was nearly the same as SDH activity (15.1 +/- 1.6 vs 16.6 +/- 2.0 U/g protein). At 600 mosmol/l, AR activity increased to 82.5 +/- 11.4 U/g protein and SDH activity to 31.5 +/- 6.0 U/g protein. Studying the time course of enzyme activity after changing osmolarity from 300 to 600 mosmol/l, we found half maximal stimulation after 2-3 (AR) or 3 (SDH) days. The amount of AR-mRNA preceded the rise of enzyme activity, whereas SDH-mRNA was not significantly influenced. Lowering osmolarity from 600 to 300 mosmol/l, enzyme activity decreased to less than half within 2 (AR) or I (SDH) day(s). Conclusions. The results suggest that sorbitol metabolism contributes to handling of osmotic stress in rat renal papillary interstitial cells
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