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    Buzzo, A.

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    Postulated mode of action of lead on aminolevulinic acid dehydratase in chronic exposure.

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    The authors studied in vitro the variations of erythrocyte ALA D activity in subjects exposed and not exposed to lead risk before and after three tests: heat treatment at 60 degrees C for five minutes, addition of GSH (1 X 10(-2) mol/l) and of zinc (1.5 X 10(-4) mol/l). A study of the ratios before and after treatments showed that GSH and zinc were better than heating in identifying false positives, and that zinc was preferable, owing to lesser dispersion of results around the mean. The ratios of ALA D activity before and after treatment is more closely correlated with PbB levels than ALA D activity without treatment. The addition of GSH restored the enzyme activity of the exposed subjects to values equal to those obtained with heating; this did not happen in the non-exposed subjects. It is postulated that, in lead exposure, the metal acts only on the thiol groups, which may then be reactivated by an optimal concentration of GSH

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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