1,720,955 research outputs found
Elicitation of multiattribute value functions through high dimensional model representations: monotonicity and interactions
No full textThis work addresses the early phases of the elicitation of multiattribute value functions proposing a practical method for assessing interactions and monotonicity. We exploit the link between multiattribute value functions and the theory of high dimensional model representations. The resulting elicitation method does not state any a-priori assumption on an individual’s preference structure. We test the approach via an experiment in a riskless context in which subjects are asked to evaluate mobile phone packages that differ on three attributes
A global tolerance approach to sensitivity analysis in linear programming
No full textThis paper takes a fresh look at sensitivity analysis in linear programming. We propose a merged approach that brings together the insights of Wendell’s tolerance and Wagner’s global sensitivity approaches. The modeler/analyst is then capable of answering questions concerning stability, trend, model structure, and data prioritization simultaneously. Analytical as well as numerical aspects of the approach are discussed for separate as well as simultaneous variations in the objective function coefficients and right-hand side terms. A corresponding efficient numerical implementation procedure is proposed. A classical production problem illustrates the findings
An integrated bioenergetics modeling approach to mitochondrial permeability transition
No full textAcute myocardial infarctions are a result of the cessation of blood carrying vital nutrients and oxygen to the myocardium. This ischemic insult is detrimental to the affected tissue and resupplying the starved tissue with blood may result in a paradoxical response. This phenomenon is known as ischemia/reperfusion injury and is estimated contribute up to 50% of the infarct size. It often leads to a lethal reperfusion injury known as mitochondrial permeability transition (MPT). MPT is an event when a pore known as the mitochondrial permeability transition pore (PTP) opens and likely results in devastating bioenergetic consequences, namely cytochrome c mediated apoptosis and necrosis. Current therapies for MPT remain inadequate, and this fact highlights the need for understanding this ischemic/reperfusion injury in order to develop better therapeutic and preventative measures. The work presented in this thesis takes a step forward in this process and begins to unravel the MPT phenomenon at a bioenergetic mechanistic level in a mathematical modeling intensive manner. Three objectives of this work will be discussed: i) the development and corroboration of a mitochondrial bioenergetics model capable of modeling Ca2+ dynamics and volume regulation, ii) the extension of the bioenergetics model to include PTP regulation and analyze its affect on bioenergetics and iii) the development of a sampling based model-driven experiment design algorithm and its implementation in designing novel experiments to identify critical parameters for the adenine nucleotide translocase-based PTP voltage-sensor hypothesis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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