169,828 research outputs found
Cucker–Smale Type Dynamics of Infinitely Many Individuals with Repulsive Forces
No full textWe study the existence and uniqueness of the time evolution of a system of infinitely many individuals, moving in a tunnel and subjected to a Cucker–Smale type alignment dynamics with compactly supported communication kernels and to short-range repulsive interactions to avoid collisions
Time Evolution of Concentrated Vortex Rings
No full textWe study the time evolution of an incompressible fluid with axisymmetry without swirl when the vorticity is sharply concentrated. In particular, we consider N disjoint vortex rings of size ε and intensity of the order of | log ε| - 1. We show that in the limit ε→ 0 , when the density of vorticity becomes very large, the movement of each vortex ring converges to a simple translation, at least for a small but positive time
Global time evolution of concentrated vortex rings
No full textWe study the time evolution of an incompressible fluid with axial symmetry without swirl, assuming initial data such that the initial vorticity is very concentrated inside N small disjoint rings of thickness ε and vorticity mass of the order of | log ε| - 1. When ε→ 0 , we show that the motion of each vortex ring converges to a simple translation with constant speed (depending on the single ring) along the symmetry axis. We obtain a sharp localization of the vorticity support at time t in the radial direction, whereas we state only a concentration property in the axial direction. This is obtained for arbitrary (but fixed) intervals of time. This study is the completion of a previous paper [5], where a sharp localization of the vorticity support was obtained both along the radial and axial directions, but the convergence for ε→ 0 worked only for short times
On the dynamics of infinitely many charged particles with magnetic confinement
No full textWe study the time evolution of a system of infinitely many charged particles confined by an external magnetic field in an unbounded cylindrical conductor and mutually interacting via the Coulomb force. We prove the existence, uniqueness and quasi-locality of the motion. Moreover, we give some nontrivial bounds on its long time behavior
Old and new drugs for treatment of advanced heart failure
No full textBackground: Advanced heart failure (HF) is a progressive disease with high mortality and limited medical therapeutic options. Long-term mechanical circulatory support and heart transplantation remain gold-standard treatments for these patients; however, access to these therapies is limited by the advanced age and multiple comorbidities of affected patients, as well as the limited number of donor organs available. Methods: Traditional and new drugs available for the treatment of advanced HF have been researched. Results: To date, the cornerstone for the treatment of patients with advanced HF remains water restriction, intravenous loop diuretic therapy and inotropic support. However, many patients with advanced HF experience loop diuretics resistance and alternative therapeutic strategies to overcome this problem have been developed, including sequential nephron blockade or use of the hypertonic saline solution in combination with high-doses of furosemide. As classic inotropes augment myocardial oxygen consumption, new promising drugs have been introduced, including levosimendan, istaroxime and omecamtiv mecarbil. However, pharmacological agents still remain mainly short-term or palliative options in patients with acute decompensation or excluded from mechanical therapy. Conclusion: Traditional drugs, especially when administered in combination, and new medicaments represent important therapeutic options in advanced HF. However, their impact on prognosis remains unclear. Large trials are necessary to clarify their therapeutic potential and prognostic role in these fragile patients
On the propagation of a perturbation in an anharmonic system
No full textWe give a not trivial upper bound on the velocity of disturbances in an infinitely extended anharmonic system at thermal equilibrium. The proof is achieved by combining a control on the non equilibrium dynamics with an explicit use of the state invariance with respect to the time evolution
Navier-Stokes equations on a flat cylinder with vorticity production on the boundary
No full textWe study a singular version of the incompressible two-dimensional Navier-Stokes (NS) system on a flat cylinder C, with Neumann conditions for the vorticity and a vorticity production term on the boundary partial derivative C to restore the no-slip boundary condition for the velocity u|partial derivative C = 0. The problem is formulated as an infinite system of coupled ordinary differential equations (ODEs) for the Neumann Fourier modes. For a general class of initial data we prove existence and uniqueness of the solution, and equivalence to the usual NS system. The main tool in the proofs is a suitable decay of the modes, obtained by the explicit form of the ODEs. We finally show that the resulting expansions of the velocity u and of its first and second space derivatives converge and define continuous functions up to the boundary
Impaired circadian heart rate variability in Parkinson's disease: A time-domain analysis in ambulatory setting
No full textBackground: Heart rate variability (HRV) decreases in Parkinson's disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. Methods: Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-h ambulatory ECG was performed. Results: Overall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ± 8.8, disease duration: 5.0 ± 4.7). Mean SCOPA-AUT score was 10.1 ± 7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-min standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN was significantly different between Parkinson's disease patients and healthy controls. Conclusions: In our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect an autonomic derangement extending all day and night long
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
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