293 research outputs found
Validation of the use of LEU uranium as a replacement for HEU in United States submarine reactors
No full textThesis: S.M., Massachusetts Institute of Technology, Department of Nuclear Science and Engineering, 2015.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 153-160).The US Navy has long used highly enriched uranium (HEU) in naval reactors for a variety of technical reasons. In a series of studies, the Department of Naval Reactors determined that switching to low enriched uranium (LEU) was impossible using current fuel designs, but may be possible with a dedicated program to investigate new fuel materials. This thesis simulated an HEU fueled submarine reactor using a uranium oxide-zirconium dispersion fuel, and compared it to an LEU reactor using a uranium-molybdenum alloy fuel. The required energy output of an attack submarine was used to set the burnup requirement of the HEU (333 MWd/kg) and LEU (93.5 MWd/kg) fueled reactors, and each reactor was depleted to the end of life. The results showed that naval reactors could be switched to LEU without sacrificing the lifetime submarine core or increasing reactor volume. Even if unstudied technological details render this impossible, an LEU core would require only a single refueling over the life of an attack submarine. This would necessitate a 3.25% increase in submarine fleet size, which is small compared to the average Department of Defense project cost overrun.by Brendan Patrick Hanlon.S.M
Erratum to: Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos (Nature Cell Biology, (2018), 20, 2, (144-151), 10.1038/s41556-017-0017-8)
No full textIn the version of this Letter originally published, an author error led to the affiliations for Brendan Payne, Jonathan Coxhead and Gavin Hudson being incorrect. The correct affiliations are: Brendan Payne:3Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.6Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; this is a new affiliation 6 and subsequent existing affiliations have been renumbered. Jonathan Coxhead:11Genomic Core Facility, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK; this is a new affiliation 11 and subsequent existing affiliations have been renumbered. Gavin Hudson:3Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK. In addition, in Fig. 2d, the numbers on the x-axis of the left plot were incorrectly labelled as negative; they should have been positive. These errors have now been corrected in all online versions of the Letter
Marquette football team, 1936
No full text1936-1937 Marquette football team that participated in the first Cotton Bowl. First row: Anthony Weiler, LeRoy McMahon, Elroy Mieritz, Roy Hovel, Joseph Cuchetti, Edward St. Eve, Joseph Lauterbach, Robert Boylan, Earl McEssy, and Myles Reif. Second row: Harold Kieffer, Ward Cuff, LeRoy Schoemann, Oliver Butler, James Fenimore Cooper, Joseph Mosovsky, William Jennings, Herbert Anderson, Raymond Buivid, Art Guepe, Al Guepe, and Raymond Sonnenberg. Third row: Ralph Kuhn, Carl Siefert, Howard Hansen, Vincent Hotton, Norman Helding, Morgan Busch, Patrick Toal, Brendan Williams, Delbert Rider, Robert Hanel, Roger Lumb, and Lloyd Tappa. Fourth row: John Puestow, John O'Melia, Wallace Lauterbach, Joseph Matt, Walter Eichenberger, Edwin Niemi, and George Knipp
Stewarding chemical control in tall waterhemp (Amaranthus tuberculatus) while foregoing statistical significance
No full textTall waterhemp (Amaranthus tuberculatus) has become a considerable problem in U.S. agriculture, especially in corn and soy cropping systems. A particularly concerning characteristic of waterhemp is its ability to rapidly evolve resistance to herbicides. While chemical control is only one component of integrated weed management, it has proven to be extremely valuable and, therefore, we should prevent its loss. It is not reasonable to believe that applying more herbicides will stop the evolution of resistance to herbicides, but models and research suggest that applying tank mixes with multiple modes of action could potentially slow down the evolution of some types of herbicide resistance. Presupposing that tank mixing will slow the evolution of resistance to herbicides, we investigated possible tank mix partners for isoxaflutole and glufosinate and evaluated whether increasing the number of modes of action will maintain efficacy while allowing for reduced application rates. Next, we provide evidence that measuring the rate of evolution to herbicide with empirical field studies may require more resources than we originally thought due in part to (we believe) treatment contamination through pollen swamping resulting in small effect sizes that require at least an order of magnitude more progeny waterhemp seed for greenhouse studies. Then, we show that investing in more complex tank mixes for chemical weed control now may pay dividends in the future by resulting in lower cumulative costs or more robust overall control even though it may not be apparent in the first year. By “robust control” we mean that the more complex herbicide mixtures appear to be less sensitive to uncertainty in seed bank returns year to year, which is desirable since waterhemp has an extreme capacity for producing seed if given the opportunity. Finally, we do this all without using p-values, statistical significance, and null hypothesis tests (which is certainly an unorthodox strategy for scientific research projects).Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-05-01The student, Brendan Alexander, accepted the attached license on 2021-04-20 at 16:52.The student, Brendan Alexander, submitted this Dissertation for approval on 2021-04-20 at 16:59.This Dissertation was approved for publication on 2021-04-21 at 09:58.DSpace SAF Submission Ingestion Package generated from Vireo submission #16412 on 2021-09-16 at 20:10:48Made available in DSpace on 2021-09-17T04:04:33Z (GMT). No. of bitstreams: 2
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Previous issue date: 2021-04-21Embargo set by: Seth Robbins for item 118678
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Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 118678
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Reason: Author requested closed access (OA after 2yrs) in Vireo ETD systemAuthor requested closed access (OA after 2yrs) in Vireo ETD systemLimite
Quantifying microenvironmental changes in the developing brain in response to acute and chronic metabolic disrupters
No full textThesis (Ph.D.)--University of Washington, 2025Neurologic diseases are responsible for nearly one-third of all deaths and disability life-adjusted years, many with no effective treatments or cures. Treating the diseased brain is challenging physically, biologically, and clinically: the brain has multiple unique barriers to therapeutics, neurologic disease processes are highly multiplexed and variable, and the presence of pre-existing co-morbidities or prior neurologic conditions changes the disease landscape, complicating or impeding treatment efforts. In this work, we touch on all three challenges. We focus on metabolic disruptions in the form of mitochondrial dysfunction, which is implicated in nearly every neurologic disease and is shown to be a mediator of risk and susceptibility. We use organotypic whole-hemisphere (OWH) brain slice cultures to quantify how mitochondrial dysfunction alters the physical and biological microenvironments of the brain. First, we develop an OWH slice model of mitochondrial dysfunction using the canonical inhibitor rotenone (ROT). We observe region-, dose-, and time-dependent microenvironmental changes that mirror in vivo models. We also show how the extracellular microenvironment, a critical therapeutic barrier, is altered by mitochondrial dysfunction. Next, we characterize how mitochondrial dysfunction from ROT exposure modulates susceptibility to stroke-like injury using an oxygen-glucose deprivation (OGD) model, an effect which has not been previously investigated in vitro. Here, we demonstrate that timing of metabolic disruption relative to the OGD insult worsens tissue recovery. Gene expression analysis and imaging reveal a connection between mitochondrial state and inflammatory responses as one driver for metabolic-related effects on OGD recovery. Our findings highlight a role of pre-existing metabolic deficits in neurological injury and recovery, capture changes in microenvironment features that can impact therapeutic delivery and enable pre-clinical screening platforms that better represent the clinical scenario for patients seeking treatment for neurologic disease
Assessment and application of density functional theory for the prediction of structure and reactivity of vanadium complexes
No full textDeveloping power quality supply enhancement procedures in buildings
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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Starting to speak : madness and the narration of identity
No full textIn this thesis I study the relationship between narrative and identity in the context of narrative representations of 'mental illness' or 'madness'. Through readings of autobiographical and fictional narrative texts, I consider how identity is textually figured, and how the disruptive effects of madness shape these figurations. I argue here for a view of psychological life as underpinned by textual and linguistic elements, and suggest that theoretical conceptions of 'narrative identity' should be reworked to account for the experience of vulnerable, marginalized subjects. In Chapter One I discuss the disruption of the sense of selfhood produced by madness; the difficulties of representing madness within a narrative form; and the ramifications of madness for 'narrative identity' as a theoretical position. In Chapter Two I discuss Lauren Slater's Spasm: A Memoir with Lies and Margiad Evans's A Ray of Darkness. Both texts relate experiences of epilepsy and depression, and, despite their very different style and tone, both propose dialogic and diffuse paradigms for autobiography. In Chapter Three I discuss Elizabeth Wurtzel's Prozac Nation. I suggest that narration in this text is insinuated as a perilous venture, and that mapped within narrative form are the reverberations of unresolved distress. Chapter Four considers difficulties inherent in the narrative and linguistic representation of madness. I discuss Foucault and Derrida's debate on this subject, Susanna Kaysen's Girl, Interrupted, and Ross Burke's The Truth Effect. Chapter Five considers Alasdair Gray's novel 1982, Janine. I argue that this text dramatizes a particular type of story-telling, and demonstrates its importance for the well- being of the self. In Chapter Six I discuss two diaries. With reference to theory by Ricoeur and Foucault, I suggest that these apparently mundane narratives of everyday life represent profound refashionings of the self. Chapter Seven summarizes my conclusions and suggests directions for future work
The built environment, Hamilton City Council policies and child driveway safety: a balancing act
No full textDriveway run-overs continue to bring tragedy to New Zealand families at a higher rate than any other Western nation. Meanwhile, little progress appears to have been made in regard to the recommendations of previous research. This project investigates whether recommendations in regard to one key factor in driveway run-overs, the built environment, are reflected in current local body policies and regulations. The research evaluates Hamilton City Council policies affecting the renovation and/or erection of domestic residences with a view to determining whether they are consistent with existing knowledge and best practice initiatives designed to minimise accidental injuries to children on driveways.
The project compares the findings of a review of the existing literature on child safety best practice for the built environment and urban design of driveways, with a review of Hamilton City Council policies and guidelines relating to the built environment of residential properties and adjacent roads (the Operative District Plan, Ten Year Plan, Urban Growth Strategy, Vista, and more), along with relevant central government policy. These findings are triangulated with data from interviews with four expert informants – one child safety expert and three Hamilton City Council employees involved in planning, policy and transport – who provide insights into the translation of policies into practice
Patterns and Soundscapes: An Album in Five Movements for Alto Saxophone, Bass Clarinet, String Quartet, Solo Viola, Two Drum Sets, and Electronics
No full textabstract: Patterns and Soundscapes explores the concept album format, popularized in the late 1960s and into modern times by artists such as the Who, Pink Floyd, and Frank Zappa. Specifically, I sought to adapt this format as a compositional process aimed towards the completion of a large-scale work that can be presented in album format and live performance. Further influenced by the concept album, I sought to create pieces consisting of similar musical techniques, motivic ideas, and harmonic language, so that each piece could be performed on its own or be combined as a multi-movement work.
I began writing this work in the spring of 2019, with “Colored Red Currents” for string quartet and “Conspiracy Wall” for two drum sets. After realizing that both pieces had a similar sound and style, I began to consider how they could function within an album format, and how they could also work together to form a large-scale musical work. I then decided that each subsequent piece, in addition to being composed of similar musical ideas, would be written in a manner that allowed for seamless transitions between the end of one and the beginning of another, and would also introduce the instrumentation making up the full ensemble in the last movement.
This work begins with the sparkling and rapid string quartet, “Colored Red Currents,” then moves to the energetic and groove based “Conspiracy Wall” for two drum sets, the meditative “Interlude” for solo viola and electronics, and the quick and mechanical “Beat Frequency” for alto saxophone, bass clarinet, and electronics. The work ends with “ALL IN,” where the full ensemble is finally formed, and all of the patterns and soundscapes come together to form a bombastic and wild finale.Dissertation/ThesisMasters Thesis Composition 202
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