323,048 research outputs found
Rosarium Busti : Rosari¯u sermonu[m] predicabilium ad faciliorem predicantium commoditatem nouiter compilatum ... : [prima-secunda pars].
No full textEl pie de imp. consta en colofónMarca tip. en port. y colofónSign.: *\p8\s, *V\p8\s, IX\p8\s, *XIII\p4\s, a-z\p8\s, [et]\p8\s, [cum]\p8\s, [rum]\p8\s, A-C\p8\s, D\p4\s ; 2A-2B\p8\s, 2a-2z\p8\s, [et]\p8\s, [cum]\p8\s, [rum]\p8\s, 2A-2T\p8\s, 2V\p10\sPort. a dos tintas con orla y grab. xilTexto a dos colCada parte con port. propiaSign.: *\p28\s, a-z\p8\s, [et]\p8\s, [cum]\p8\s, [rum]\p8\s, A-C\p8\s, D\p4\s ; 2A-2B\p8\s, 2a-2z\p8\s, [et]\p8\s, [cum]\p8\s, [rum]\p8\s, 2A-2T\p8\s, 2V\p10\
Genome tools for detecting and retrieving uncultured antibiotic producing bacteria
No full textThe discovery and the development of new antibiotics and other bioactive compounds continue to be an important goal in modern medicin
A coarse-grain model for cellular growth accounting for ribosome synthesis
No full textProtein synthesis in eukaryotes is carried out by ribosomes, large RNA-protein complexes consisting of a small and a large subunit. In this work we present a mathematical model for cellular growth comprising both protein production and ribosome synthesis, properly accounting for both small and large subunits dynamics. The qualitative analysis of the model is carried out according to a simplifying assumption on the proportion of the two ribosomal subunits in stationary growth conditions; such hypothesis is based on a reasonable biological ground. Conditions are given on the model parameters in order to ensure exponential growth and the corresponding growth rate is straightforwardly computed from the model parameters. These results are validated by numerical simulations carried out according to a set of biologically meaningful model parameters. The modified model is better suited to host molecular blow-up of ribosomal synthesis and cell growth within a modular whole-cell model able to act as a scaffold connecting metabolism, growth and cycle
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Whi5 phosphorylation embedded in the G1 /S network dynamically controls critical cell size and cell fate
No full textIn budding yeast, overcoming of a critical size to enter S phase and the mitosis/mating switch - two central cell fate events - take place in the G 1 phase of the cell cycle. Here we present a mathematical model of the basic molecular mechanism controlling the G 1 /S transition, whose major regulatory feature is multisite phosphorylation of nuclear Whi5. Cln3-Cdk1, whose nuclear amount is proportional to cell size, and then Cln1,2-Cdk1, randomly phosphorylate both decoy and functional Whi5 sites. Full phosphorylation of functional sites releases Whi5 inhibitory activity, activating G 1 /S transcription. Simulation analysis shows that this mechanism ensures coherent release of Whi5 inhibitory action and accounts for many experimentally observed properties of mitotically growing or conjugating G 1 cells. Cell cycle progression and transcriptional analyses of a Whi5 phosphomimetic mutant verify the model prediction that coherent transcription of the G 1 /S regulon and ensuing G 1 /S transition requires full phosphorylation of Whi5 functional sites
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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