1,721,253 research outputs found
Reply to letter: “RE: Association of obstructive sleep apnea with non-alcoholic fatty liver disease in patients with obesity: an observational study”
No full textMetabolically Healthy Obesity and Bariatric Surgery
Full text linkA peculiar category of persons with obesity lacking common metabolic disturbances has been depicted and termed as metabolically healthy obesity (MHO). Yet, although MHO patients are free of obesity-associated complications, they might not be entirely precluded from developing cardio-metabolic disorders. Among patients with morbid obesity (MO) who are referred to bariatric surgery, a subset of metabolically healthy MO (MHMO) has been identified and the question arises if these patients would benefit from surgery in terms of mitigating the peril of cardio-metabolic complications. We revisited the pathophysiological mechanisms that define MHO, the currently available data on the cardio-metabolic risk of these patients and finally we reviewed the benefits of bariatric surgery and the urge to better characterize MHMO before submission to surgery
Pharmacotherapy of obesity: An update
No full textSeveral pharmacological approaches to controlling body weight have been developed over the last decades, albeit with limited success. Currently available agents include centrally acting appetite suppressants and peripherally acting compounds. Efficacy and safety of these agents in the clinical setting require a difficult balance. Further strategies including multiagonists able to simultaneously target multiple actors involved in obesity initiation and expansion such as the glucagon receptor family are under investigation. The results of recent clinical trials are encouraging and highlight emerging compounds as potential game changers. In view of the rising prevalence of obesity and the associated burden of comorbidities worldwide, and compared with other areas of pharmacological intervention, we feel that the field of obesity has been affected by therapeutic inertia. Of note, obesity may also affect the response to concomitant medications such as low-dose aspirin. Lessons from withdrawn agents such as the cannabinoid receptor antagonist rimonabant include developing compounds with a more targeted action profile (i.e., central vs peripheral, or antagonist versus inverse agonist) as well as careful selection of patients based on individual risk factors. We anticipate that the expanding knowledge base and clinical testing will result in improved outcomes for patients with obesity in the near future
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Reactions of diiron m-aminocarbyne complexes containing nitrile ligands
Full text linkThe acetonitrile ligand in the mu-aminocarbyne complexes [Fe2{mu-CN(Me)R}(mu-CO)(CO)(NCMe)(Cp)2][SO 3CF3] (R = Me, 2a, CH2Ph, 2b, Xyl, 2c) (Xyl = 2,6-Me2C6H3) is readily displaced by halides and cyanide anions affording the corresponding neutral species [Fe2{mu-CN(Me)R}(mu-CO)(CO)(X)(Cp)2 ] (X = Br, I, CN). Complexes 2 undergo deprotonation and rearrangement of the coordinated MeCN upon treatment with organolithium reagents. Trimethylacetonitrile, that does not contain acidic alpha hydrogens has been used in place of MeCN to form the complexes [Fe2{mu-CN(Me)R}(mu-CO)(CO)(NCCMe3 )(Cp)2][SO3CF3] (7a-c). Attempts to replace the nitrile ligand in 3 with carbon nucleophiles (by reaction with RLi) failed, resulting in decomposition products. However the reaction of 7c with LiCºCTol (Tol = C6H4Me), followed by treatment with HSO3CF3, yielded the imino complex [Fe2{mu-CN(Me)Xyl}(mu-CO)(CO) {N(H)C(CºCC6H4Me-4)CMe3}(Cp) 2][SO3CF3 ] (8), obtained via acetilyde addition at the coordinated NCCMe3
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Coupling of allenes with m-alkylidyne ligands in diiron complexes: synthesis of novel bridging thio- and aminobutadienylidene complexes
No full textThe diiron aminocarbyne complexes [Fe2{μ-CN(Me)(R)}(μ-CO)(CO)2(Cp)2][SO3CF3] (R = Xyl, 1a; R = 4-C6H4OMe, 1b; R = Me, 1c; Xyl = 2,6-Me2C6H3) react with allenes of the type CH2=C=CR′R′′, in the presence of Me3NO/Et3N, to give the novel butadienylidene complexes [Fe2{μ-η1:η3-CαN(R)(Me)Cβ(H)CγCδ(R′)(R′′)}(μ-CO)(CO)(Cp)2] (R = Xyl, R′ = R′′ = Me, 3a; R = Xyl, R′ = Me, R′′ = H, 3b; R = Xyl, R′ = CO2Et, R′′ = H, 3c; R = 4-C6H4OMe, R′ = CO2Et, R′′ = H, 3d; R = R′ = R′′ = Me, 3e; R = Me, R′ = CO2Et, R′′ = H, 3f) in high yields. Analogously, the diiron thiocarbyne complex [Fe2(μ-CSMe)(μ-CO)(CO)2(Cp)2][SO3CF3] (2) reacts with CH2=C=CR′R′′, in the presence of Me3NO/Et3N, to afford the compounds[Fe2{μ-η1:η3-CαS(Me)Cβ(H)CγCδ(R′)(R′′)}(μ-CO)(CO)(Cp)2](R′ = R′′ = Me, 4a; R′ = CO2Et, R′′ = H, 4b; R′ = SiMe3, R′′ = Me, 4c). Complexes 3–4 exist in solution as mixtures of cis and trans isomers. Compounds 3a and 3e, upon treatment with HSO3CF3, are transformed into the corresponding vinyliminium complexes [Fe2{μ-η1:η3-Cγ(CδHMe2)CβHCαN(R)(Me)}(μ-CO)(CO)(Cp)2][SO3CF3] (R = Xyl, 5a; R = Me, 5b), in nearly quantitative yields. Conversely, compounds 4a,b undergo methylation (by CH3SO3CF3) at the sulfur to give the cationic complexes [Fe2{μ-η1:η3-Cα(SMe2)Cβ(H)CγCδ(R′)(R′′)}(μ-CO)(CO)(Cp)2][SO3CF3] (R′ = R′′ = Me, 7a; R′ = CO2Et, R′′ = H, 7b). Protonation of 3a is not reversible: treating 5a with sodium hydride results in the formation of the 1-metalla-2-amino-cyclopenta-1,3-dien-5-one species [Fe(Cp)(CO){CN(Me)(Xyl)CHC(CHMe2)C(O)}] (6). The molecular structures of cis-3a, cis-4b, 5a[CF3SO3]·CH2Cl2 and 7a[CF3SO3]·0.5CH2Cl2 have been determined by X-ray diffraction studies
Correction to: Diet approach before and after bariatric surgery (Reviews in Endocrine and Metabolic Disorders, (2020), 21, 3, (297-306), 10.1007/s11154-020-09571-8)
No full textThe original version of this article unfortunately, has the incorrect title reported in the published paper. The title of the Journal - Reviews in endocrine and metabolic disorders was captured and not the original title of the manuscript which is ‘Diet approach before and after bariatric surgery’. Thus, this erratum is presented to fix the error. The original article has been corrected
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