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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Role of matrix metalloproteinases and their inhibitors in the development of cervical metastases in papillary thyroid cancer
No full textPapilarni karcinom najčešći je karcinom štitnjače s porastom incidencije u svijetu. Obilježen je visokim brojem vratnih metastaza. Istraživanja invazije i metastaziranja identificirala su metaloproteinaze matriksa (MMP) kao ključne enzime u procesima tumorske diseminacije, osobito MMP-1, -2 i -9. Aktivnost MMP-a mogu modulirati tkivni inhibitori metaloproteinaza matriksa (TIMP 1-4). Ovo je istraživanje retrospektivno i istražuje ekspresije MMP-1, -2 i -9 te TIMP-1 i -2 u tkivu papilarnog karcinoma štitnjače. Cilj istraživanja bio je imunohistokemijski utvrditi povezanost MMP-a i TIMP-a s obrascem metastaziranja papilarnog karcinoma. Dobiveni rezultati pokazuju da su najviše ekspresije MMP-1 i TIMP-1 bile kod bolesnika s metastazama u lateralnim regijama vrata, dok se ekspresije MMP-2, MMP-9 i TIMP-2 nisu statistički razlikovale ovisno o obrascu metastaziranja. Analizirajući bolesnike u skupinama s metastazama i bez njih uočila se povezanost ekspresije ponovno MMP-1 i TIMP-1 s metastatskom skupinom. Uspoređujući kliničko patološke značajke i ekspresiju, zabilježene su značajne pozitivne korelacije MMP-1 sa stadijem bolesti i brojem zahvaćenih limfnih čvorova, TIMP-1 s brojem limfnih čvorova i stadijem tumora te TIMP-2 s veličinom tumora i brojem limfnih čvorova. Sukladno ovom istraživanju pretpostavljamo da su ekspresije MMP-1 i TIMP-1 povezane s obrascem metastaziranja papilarnog karcinoma štitnjače, dok se razina ostalih analiziranih proteina ne povezuje s obrascem metastaziranja.Papillary carcinoma is the most common thyroid cancer with the incidence increasing worldwide. It is characterized by a high number of cervical metastases. Research of the invasiveness and metastatic processes identified matrix metalloproteinases (MMP) as a key enzyme family in tumor progression, especially MMP-1, -2 and -9. MMP activity can be modulated by tissue inhibitors of matrix metalloproteinase (TIMP 1-4). This research retrospectively investigated the expression of MMP-1, -2 and -9, as well as TIMP-1 and -2 in papillary thyroid carcinoma tissue. The aim of the study was to determine the association of MMP and TIMP with papillary thyroid cancer metastasis pattern by immunohistochemistry. The results obtained showed highest expression of MMP-1 and TIMP-1 in cancer tissue of patients with metastasis in the lateral region, while MMP-2, MMP-9 and TIMP-2 did not differ statistically according to the metastasis pattern. Comparing clinical features with expression data, MMP-1 significantly correlated with the disease stage and number of positive lymph nodes, TIMP-1 with number of positive lymph nodes and tumor stage, and TIMP-2 with tumor size and number of positive lymph nodes. According to this study, MMP-1 and TIMP-1, unlike other proteins analysed, appear to be associated with the papillary thyroid cancer metastasis patter
Role of matrix metalloproteinases and their inhibitors in the development of cervical metastases in papillary thyroid cancer
No full textPapilarni karcinom najčešći je karcinom štitnjače s porastom incidencije u svijetu. Obilježen je visokim brojem vratnih metastaza. Istraživanja invazije i metastaziranja identificirala su metaloproteinaze matriksa (MMP) kao ključne enzime u procesima tumorske diseminacije, osobito MMP-1, -2 i -9. Aktivnost MMP-a mogu modulirati tkivni inhibitori metaloproteinaza matriksa (TIMP 1-4). Ovo je istraživanje retrospektivno i istražuje ekspresije MMP-1, -2 i -9 te TIMP-1 i -2 u tkivu papilarnog karcinoma štitnjače. Cilj istraživanja bio je imunohistokemijski utvrditi povezanost MMP-a i TIMP-a s obrascem metastaziranja papilarnog karcinoma. Dobiveni rezultati pokazuju da su najviše ekspresije MMP-1 i TIMP-1 bile kod bolesnika s metastazama u lateralnim regijama vrata, dok se ekspresije MMP-2, MMP-9 i TIMP-2 nisu statistički razlikovale ovisno o obrascu metastaziranja. Analizirajući bolesnike u skupinama s metastazama i bez njih uočila se povezanost ekspresije ponovno MMP-1 i TIMP-1 s metastatskom skupinom. Uspoređujući kliničko patološke značajke i ekspresiju, zabilježene su značajne pozitivne korelacije MMP-1 sa stadijem bolesti i brojem zahvaćenih limfnih čvorova, TIMP-1 s brojem limfnih čvorova i stadijem tumora te TIMP-2 s veličinom tumora i brojem limfnih čvorova. Sukladno ovom istraživanju pretpostavljamo da su ekspresije MMP-1 i TIMP-1 povezane s obrascem metastaziranja papilarnog karcinoma štitnjače, dok se razina ostalih analiziranih proteina ne povezuje s obrascem metastaziranja.Papillary carcinoma is the most common thyroid cancer with the incidence increasing worldwide. It is characterized by a high number of cervical metastases. Research of the invasiveness and metastatic processes identified matrix metalloproteinases (MMP) as a key enzyme family in tumor progression, especially MMP-1, -2 and -9. MMP activity can be modulated by tissue inhibitors of matrix metalloproteinase (TIMP 1-4). This research retrospectively investigated the expression of MMP-1, -2 and -9, as well as TIMP-1 and -2 in papillary thyroid carcinoma tissue. The aim of the study was to determine the association of MMP and TIMP with papillary thyroid cancer metastasis pattern by immunohistochemistry. The results obtained showed highest expression of MMP-1 and TIMP-1 in cancer tissue of patients with metastasis in the lateral region, while MMP-2, MMP-9 and TIMP-2 did not differ statistically according to the metastasis pattern. Comparing clinical features with expression data, MMP-1 significantly correlated with the disease stage and number of positive lymph nodes, TIMP-1 with number of positive lymph nodes and tumor stage, and TIMP-2 with tumor size and number of positive lymph nodes. According to this study, MMP-1 and TIMP-1, unlike other proteins analysed, appear to be associated with the papillary thyroid cancer metastasis patter
Uloga metaloproteinaza matriksa i njihovih inhibitora u razvoju vratnih metastaza papilarnoga karcinoma štitne žlijezde [Role of matrix metalloproteinases and their inhibitors in the development of cervical metastases in papillary thyroid cancer]
Get PDFPapillary carcinoma is the most common thyroid cancer with the incidence increasing worldwide. It is characterized by a high number of cervical metastases. Research of the invasiveness and metastatic processes identified matrix metalloproteinases (MMP) as a key enzyme family in tumor progression, especially MMP-1, -2 and -9. MMP activity can be modulated by tissue inhibitors of matrix metalloproteinase (TIMP 1-4). This research retrospectively investigated the expression of MMP-1, -2 and -9, as well as TIMP-1 and -2 in papillary thyroid carcinoma tissue. The aim of the study was to determine the association of MMP and TIMP with papillary thyroid cancer metastasis pattern by immunohistochemistry. The results obtained showed highest expression of MMP-1 and TIMP-1 in cancer tissue of patients with metastasis in the lateral region, while MMP-2, MMP-9 and TIMP-2 did not differ statistically according to the metastasis pattern. Comparing clinical features with expression data, MMP-1 significantly correlated with the disease stage and number of positive lymph nodes, TIMP-1 with number of positive lymph nodes and tumor stage, and TIMP-2 with tumor size and number of positive lymph nodes. According to this study, MMP-1 and TIMP-1, unlike other proteins analysed, appear to be associated with the papillary thyroid cancer metastasis patter
Role of matrix metalloproteinases and their inhibitors in the development of cervical metastases in papillary thyroid cancer
No full textPapilarni karcinom najčešći je karcinom štitnjače s porastom incidencije u svijetu. Obilježen je visokim brojem vratnih metastaza. Istraživanja invazije i metastaziranja identificirala su metaloproteinaze matriksa (MMP) kao ključne enzime u procesima tumorske diseminacije, osobito MMP-1, -2 i -9. Aktivnost MMP-a mogu modulirati tkivni inhibitori metaloproteinaza matriksa (TIMP 1-4). Ovo je istraživanje retrospektivno i istražuje ekspresije MMP-1, -2 i -9 te TIMP-1 i -2 u tkivu papilarnog karcinoma štitnjače. Cilj istraživanja bio je imunohistokemijski utvrditi povezanost MMP-a i TIMP-a s obrascem metastaziranja papilarnog karcinoma. Dobiveni rezultati pokazuju da su najviše ekspresije MMP-1 i TIMP-1 bile kod bolesnika s metastazama u lateralnim regijama vrata, dok se ekspresije MMP-2, MMP-9 i TIMP-2 nisu statistički razlikovale ovisno o obrascu metastaziranja. Analizirajući bolesnike u skupinama s metastazama i bez njih uočila se povezanost ekspresije ponovno MMP-1 i TIMP-1 s metastatskom skupinom. Uspoređujući kliničko patološke značajke i ekspresiju, zabilježene su značajne pozitivne korelacije MMP-1 sa stadijem bolesti i brojem zahvaćenih limfnih čvorova, TIMP-1 s brojem limfnih čvorova i stadijem tumora te TIMP-2 s veličinom tumora i brojem limfnih čvorova. Sukladno ovom istraživanju pretpostavljamo da su ekspresije MMP-1 i TIMP-1 povezane s obrascem metastaziranja papilarnog karcinoma štitnjače, dok se razina ostalih analiziranih proteina ne povezuje s obrascem metastaziranja.Papillary carcinoma is the most common thyroid cancer with the incidence increasing worldwide. It is characterized by a high number of cervical metastases. Research of the invasiveness and metastatic processes identified matrix metalloproteinases (MMP) as a key enzyme family in tumor progression, especially MMP-1, -2 and -9. MMP activity can be modulated by tissue inhibitors of matrix metalloproteinase (TIMP 1-4). This research retrospectively investigated the expression of MMP-1, -2 and -9, as well as TIMP-1 and -2 in papillary thyroid carcinoma tissue. The aim of the study was to determine the association of MMP and TIMP with papillary thyroid cancer metastasis pattern by immunohistochemistry. The results obtained showed highest expression of MMP-1 and TIMP-1 in cancer tissue of patients with metastasis in the lateral region, while MMP-2, MMP-9 and TIMP-2 did not differ statistically according to the metastasis pattern. Comparing clinical features with expression data, MMP-1 significantly correlated with the disease stage and number of positive lymph nodes, TIMP-1 with number of positive lymph nodes and tumor stage, and TIMP-2 with tumor size and number of positive lymph nodes. According to this study, MMP-1 and TIMP-1, unlike other proteins analysed, appear to be associated with the papillary thyroid cancer metastasis patter
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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