499 research outputs found
Anne-baba Soruyor, Akademisyen Cevap Veriyor
No full text##nofulltext##Özgülük, Sıdıka Burcu (MEF Author)..
Investigation of the Role Self- Compassion and Basic Psychological Needs Play in Adolescents’ Cyber- Bullying Behaviors
No full textÖzgülük, Sıdıka Burcu (MEF Author)##nofulltext##..
Kablosuz Algılayıcı Ağlarda Bulut Bilişim ile Servis Kalitesinin Arttırılması
No full textGünümüzde, kablosuz algılayıcı ağlar (kaa) sağlık, askeriye, çevre, endüstri gibi birçok önemli alanda kullanılmaktadır. Ancak, kablosuz algılayıcı ağların bellek, enerji, hesaplama, iletişim ve ölçeklenebilirlik açısından sahip oldukları kısıtlar, bu alanlarda elde edilen çok sayıda kablosuz algılayıcı ağ verilerinin etkin yönetilebilmesinde önemli bir sorun oluşturmaktadır. Geleneksel kablosuz algılayıcı ağlar, ağ kapsamında bulunan çevresel bilgileri algılamak, toplamak ve işlemek için kullanılır. Toplanan verinin büyük ölçekte oluşu sebebiyle, belirli zamanlarda veri tabanlarından geçmiş veriler temizlenir. Bu durum geçmişe dönük raporların alınamamasına ve ileriye dönük tahmin hesaplarının tutarsız olmasına neden olur. Bu çalışmada, bulut bilişim, düşük maliyetle ölçeklenebilir ve sanallaştırılmış şekilde esnek hesaplama, depo alanı ve yazılım altyapısı hizmeti sağlaması sebebiyle umut verici bir teknoloji olmaktadır. Geliştirilen sistem yüksek hesaplama gücü ve sınırsız depolama kapasitesi içermesiyle, herhangi bir akıllı cihazla çevresel bilgilerin gerçek zamanlı olarak her yerden izlenebilmesini sağlanmaktadır
Dental follicle mesenchymal stem cells ameliorated glandular dysfunction in Sjögren’s syndrome murine model
No full textOBJECTIVE: Dental mesenchymal stem cells (MSCs) are potential for use in tissue regeneration in inflammatory diseases due to their rapid proliferating, multilineage differentiation, and strong anti-inflammatory features. In the present study, immunoregulatory and glandular tissue regeneration effects of the dental follicle (DF)MSCs in Sjögren’s Syndrome (SS) were investigated. METHODS: Dental follicle (DF) tissues were obtained from healthy individuals during tooth extraction, tissues were digested enzymatically and DFMSCs were cultured until the third passage. DFMSCs were labeled with Quantum dot 655 for cell tracking analysis. The induction of the SS mouse model was performed by the injection of Ro60-273-289 peptide intraperitoneally. DFMSCs were injected intraperitoneally, or into submandibular, or lacrimal glands. Splenocytes were analyzed for intracellular cytokine (IFN-γ, IL-17, IL-10) secretion in T helper cells, lymphocyte proliferation, and B lymphocyte subsets. Histologic analysis was done for submandibular and lacrimal glands with hematoxylin-eosin staining for morphologic examination. RESULTS: The systemic injection of DFMSCs significantly reduced intracellular IFN-γ and IL-17 secreting CD4+ T cells in splenocytes (p<0.05), and decreased inflammatory cell deposits and fibrosis in the glandular tissues. DFMSCs differentiated to glandular epithelial cells in submandibular and lacrimal injections with a significant reduction in lymphocytic foci. The results showed that few amounts of DFMSCs were deposited in glandular tissues when applied intraperitoneally, while high amounts of DFMSCs were located in glandular tissues and differentiated to glandular epithelial cells when applied locally in SS murine model. CONCLUSION: DFMSCs have the potential for the regulation of Th1, Th17, and Treg balance in SS, and ameliorate glandular dysfunction. DFMSCs can be a beneficial therapeutic application for SS
Identify Commonly Affected Pathways in Psychiatric Diseases
No full textBakir-Gungor, Burcu/0000-0002-2272-6270Genome-wide association studies (GWAS) are an extraordinary source of information when it comes to revealing the common variations of human complex diseases. Until now, the large amount of data generated from these studies have not been shown its full potential enough to identify the molecular and functional framework to be able to understand how a molecular system works. Following a more specific perspective, this study focused on the identification of commonly affected pathways of psychiatric diseases. The pathway term as used in molecular biology, depicts a simplified model of a process within the cell or tissue. Lately, several GWAS datasets are publicly available for various disease types such as psychiatric, immune-related, neurodegenerative, cardiovascular and such. A study on each disease and pairwise comparison to understand the behavior of disease and system would be time consuming and exhaustive. Instead of handling the results of these studies one by one, grouping diseases by target points is a more efficient way. This work aims to get one step closer to reveal key points of diseases and target these points to develop personalized medicine approaches. Especially for complex diseases, every drug doesn't show the same effect in every people. This paper contains the definition of molecular pathways, methods to identify disease related pathways, and to find common pathways pairwise in psychiatric diseases. © 2019 Elsevier B.V., All rights reserved
Demand and supply of real estate market in Turkey : a cointegration analysis
No full textCataloged from PDF version of article.Includes bibliographical references leaves 72-77.Since in a country the housing market is a leading indicator for
the whole economy, the determinants, that are affecting aggregate
housing supply and demand, are widely searched. In this study, we try
to find the variables which are affecting the demand and supply of real
estate market in Turkey between the years 1970 to 2007. We can not
specialize on the housing market and rather study the real estate
market in the aggregate‐‐‐number of dwellings is our quantity
measure‐‐‐due to data limitations. We chose Topel and Rosen’s (1988)
demand and supply models that are basically based on different short‐
and long‐run elasticity. As demand side independent variables, interest
rate, value variable, income and population are chosen and as supply
side independent variables, value, interest rate and costs are chosen.Value is used as a proxy since the market price data does not exist in
Turkey. Value is a kind of cost that is taken from the builder without
interested in what the materials are and how much the labor costs to
the builder. Also, the annual data is used because of the data
limitations. Due to the fact that all these variables are I(1), Johansen
Cointegration and VECM are preferred. According to the empirical
findings, the signs of all the variables are as expected and are
significant in the long‐run. However, in the short‐run, only interest rate
and cost variables are significant in 90% confidence level. Furthermore,
the price elasticity of supply is 1.5 in the long‐run while it is 0.13 in the
short‐run. This shows us that the adjustment costs for a change in
Turkey is significantly high. Moreover, the long‐run price elasticity of
demand is ‐4.97. Bulut, Zeynep Burc
Homofermentative lactic acid bacteria of a traditional cheese, Comlek peyniri from Cappadocia region
No full textComlek peyniri is a typical artisanal cheese in Central Anatolia. This type of cheese was made by using the indigenous lactic acid bacteria (LAB) flora of cow or ewes' milk. Majority of the samples were taken from fresh cheese because the aim was to isolate homofermentative LAB. Initially 661 microbial isolates were obtained from 17 cheese samples. Only 107 were found to be homofermentative LAB. These isolates were selected and identified by using both phenotypic and molecular methods. Phenotypic identification included curd formation from skim milk, catalase test, Gram staining and light microscopy, growth at different temperatures and salt concentrations, arginine hydrolysis, gas production from glucose, and carbohydrate fermentation. Molecular identification was based on the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) of the 16S rRNA gene-ITS (internally transcribed spacer) region. By combining the phenotypic and molecular identification results, isolates belonging to each of the following genera were determined at species or subspecies level: 54 Lactococcus lactis subsp. lactis, 21 Enterococcus faecium, 3 Ec. faecalis, 2 Ec. durans, 10 Ec. sp., 15 Lactobacillus paracasei subsp. paracasei, and 2 Lb. casei strains. Technological characterisation was also performed by culturing each of the strains in UHT skim milk, and by monitoring pH change and lactic acid production at certain time intervals through the 24 h incubation. Results of the technological characterisation indicated that 33% of the isolates (35 strains) were capable of lowering the pH of UHT milk below 5.3 after 6 h incubation at 30°C. Thirty four of these strains were Lc. lactis subsp. lactis, and only one was an Ec. faecium strain
Relationship between renewable energy and employment in European countries and Turkey : A panel data analysis
No full textBu tezde 1991 yılından 2015 yılına kadar geçen dönemde AB-15 ülkeleri ve Türkiye’deki yenilenebilir enerji tüketiminin istihdam üzerindeki etkisi incelenmektedir. Birinci bölümde sürdürülebilir kalkınma anlayışı çerçevesinde yenilenebilir enerjinin tanımı, önemi ve yenilenebilir enerji türlerine dair bilgilere yer verilmiştir. Bunun yanında yenilenebilir enerji hakkındaki güncel temel göstergeler bulunmaktadır. İkinci bölümde yeşil işlerin tanımı, gelişim süreci ve yenilenebilir enerji sektörünün yarattığı istihdam rakamları yer almaktadır. Üçüncü bölümde ise ampirik uygulama kısmı bulunmaktadır. Bu kısım literatür özeti, kullanılan yöntem hakkında bilgiler ve analiz sonuçlarını içermektedir. Toplam 16 ülkenin yer aldığı çalışmada analiz sonuçlarına göre sadece Finlandiya’da yenilenebilir enerji tüketiminden istihdama doğru nedensellik ilişkisi ortaya çıkmıştır.In this thesis, the impacts of renewable energy consumption on employment in EU-15 countries and Turkey have been examined from 1991 to 2015. In the first part of the thesis, the definition and importance of renewable energy within the framework of sustainable development understanding have been explained. In addition, information on renewable energy types and current data on renewable energy have been expressed. The second section includes the definition of green jobs, the development process and the employment data created by the renewable energy sector. In the last part of the thesis, there is an empirical application section. This section involve a summary of the literature, information about the method used and the results of the analysis. According to the results of the study, which consists of 16 countries, the causal relationship from renewable energy consumption to employment has emerged only in Finland
Exploring Pre-service Language Teachers⿿ Perceptions and Actual Practices of Giving Feedback in Micro-teaching
No full textAbstractFeedback has considerably been acknowledged as a significant component of language teaching. Although there are several studies on the effectiveness of giving feedback to pre-service language teachers to improve their teaching practices by their instructors or their peers, the actual feedback provided by them during their micro-teaching practices has not received adequate attention. Therefore, the aim is twofold: to investigate the perceptions of pre-service language teachers regarding their oral feedback providing practices during their micro-teaching implementations, and to carry out content analysis of their micro-teaching practices to determine the frequency and variety of the feedback provided by them during their micro-teaching practices. The study was carried out with 40 pre-service language teachers at Sakarya University. An open ended questionnaire with eight questions was employed in order to determine pre-service language teachers⿿ perceptions. For the actual practices, pre-service language teachers were asked to video record their micro-teachings, and two researchers watched them. The findings of the study have not been finalized yet. With the current study, similarities and differences between pre-service language teachers⿿ perceptions and their actual practices will be investigated
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