1,720,989 research outputs found
Chronic Venous Ulceration of the lower limbs and Thrombosis.
No full textChronic venous ulceration is a major complication of chronic venous disorder with important implications in terms of mor- bidity and social expenditure. Venous thrombosis and throm- bophilia are widespread conditions, often associated with venous ulcers of the lower limbs. This link has not yet been widely described in the literature and aim of this work was to analyze the relationship between these two conditions review- ing the current literature. PubMed, Scopus and ScienceDirect databases were searched for articles using the terms: throm- bophilia, venous ulceration, chronic venous disorders and the significant full text were downloaded and analyzed. From the literature review, a description of the most common throm- bofilic abnormalities found in literature and the relation- ship with CVU was given. Conditions such as antithrombin deficiency, protein C deficiency, protein S deficiency, factor V Leiden, hyperhomocystinaemia, prothrombin G20210A mutation, antiphospholipid antibodies, elevated factor VIII levels, elevated factor XI levels, plasminogen activator inhibi- tor type 1 mutations, cancer, obesity, pregnancy and trauma through current literature were statistically linked to the presence of chronic venous ulceration. The main conclusion to be drawn from the available literature is that patients with chronic venous ulceration of the lower limbs appear to have a prevalence of thrombophilia and/or thromboembolic events that is much higher than in the general populatio
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Metalloproteinases-9 and Neutrophil Gelatinase-Associtated Lipocalin Plasma and Tissue Levels Evaluation in Middle Cerebral Artery Aneurysms
No full textBackground. Cerebral aneurysms are relatively common
in adults, with a prevalence ranging between 1% and 5%. Subarachnoid hemorrhage, following aneurismal rupture,
is a major cause of death and disability in these patients.
Matrix Metalloproteinases (MMPs) and Neutrophil Gelatinase- Associated Lipocalin (NGAL) seem to be involved in the pathogenesis and in the clinical course of aneurysms. In this study, we evaluated the relationship between tissue and
plasma levels of MMP-9 and NGAL in patient with ruptured
and unruptured middle cerebral artery aneurysms. Methods.
An open label study was conducted on 7 patients with middle cerebral aneurysms. Three patients had ruptured aneurysms (Group I) and four patients had unruptured aneurysms (Group II). All patients underwent aneurysm clipping. Plasma levels of MMP-9 and NGAL were evaluated through ELISA Test. During the surgery, biopsies of the aneurysmatic arteries were taken and frozen ( 80°C) for Western blot evaluation of MMPs and NGAL expression. Four healthy volunteers (Group III) represented the control group for ELISA testing. Results. Both plasma MMP-9 and NGAL levels were significantly high in aneurysmatic patients respect to those of control patients, and these levels were higher (P 0.01) in patients with ruptured aneurysms respect to patients with unruptured aneurysms (P 0.01). The latest findings were similarly evident in tissue evaluation of MMP-9 and NGAL between ruptured and unruptured aneurysms. Conclusion. This study suggests that MMP-9 and NGAL plasma levels may be useful to predict the clinical course of a cerebral aneurysms in order to evaluate the progression of the disease and the tendency of an aneurysm to rupture
Angiosome-targeted revascularisation in diabetic foot ulcers.
No full textPeripheral vascular disease is a common complication of type 2 diabetes and is often more severe and diffuse than in non-diabetic individuals with a higher risk of major amputations in the lower limbs. Diabetic foot revascularisation using both traditional bypass surgery and endovascular therapy are often burdened by the failure and the inevitable subsequent massive amputation. In this study, we examined the clinical response of diabetic patients with critical limb ischaemia and extended ischaemic wounds, treated with a new angiosome-based revascularisation technique. In a 3-year period, nine diabetic patients with imminent amputation threatening and foot ulcers with no feasible arterial revascularisation options were treated by the angiosome- based surgical technique by means of deep vein arterialisation. The postoperative tcPO2 evaluation showed a mean increase in the cutaneous oxygen tension in all patients treated. The overall survival rates were 88·88%, 88·88% and 77·77% at 12, 24 and 36 months, respectively. Limb salvage was 100% at 1year and steady at 88·88% thereafter. Surgical deep venous arterialisation might be considered as an extreme alternative to attempt tissue preservation in limbs unfit for conventional arterial revascularisations. This technique would give advantages to the patients in terms of better compliance to the minor amputations and thus avoiding major limb amputation
Haemodynamic Surgery versus Conventional Surgery in Chronic Venous Disease: A multicenter retrospective study.
No full textAim. Chronic venous disease (CVD) is a common disease with a high prevalence in western countries. Standard open vari- cose vein surgery, usually sapheno-femoral junction ligation, great saphenous vein stripping and multiple phlebectomies, has been used to treat varicose veins for a long time. Within the last decade new alternatives to surgical treatment have been developed such us hemodynamic surgery. Aim of this study was to compare hemodynamic strategy versus stand- ard open surgery.
Methods. A retrospective multicenter study, between 1994 and 2012, was conducted; 11026 patients (4051 M; 6975F) with CVD were surgically treated for their conditions (me- dian age 45.5 years; age range 21-67); 6044 were treated with CHIVA procedure (Group A) and 4982 were treated with Stripping procedure (Group B). All patients were followed- up for the following parameters: pain; edema; ectasia; pig- mentation; duplex ultrasound controls; recurrence rate. Results. The median follow-up was 9 years for both groups. Duplex controls showed in Group A (CHIVA) respect to Group B (stripping), from the very beginning of follow-up, an optimal improvement of hemodynamic situation. Disappear- ance of symptoms and signs was more evident in Group B (stripping) compared to Group A (CHIVA) at the early follow- up. In the middle and in the late follow-up, a higher number of patients of Group A (CHIVA) showed an improvement of all symptoms and signs respect to Group B (stripping). Conclusion. Hemodynamic surgery, compared to conven- tional surgery, seems to improve results improving clinical and instrumental conditions of treated patients reducing also recurrence of varicose veins
- …
