173 research outputs found
Ellipse detection on embryo imaging using Random Sample Consensus (RANSAC) method based on arc segment
Full text linkIn Vitro Fertilization (IVF) is a method which is used to help couples who have a fertility problem. One of the problems of IVF is the success rate, which is only about 30%. One cause of the problem is the embryo morphology observation done by embryologist manually. Morphologically normal embryo does not mean the embryos are genetically normal. The aforementioned phenomena can be tested by using time lapse recording in which unavailable in the manual observation. Therefore it is very important to establish method for time lapsed recording of the embryos. This can be done by automatic observation on the embryo image, where the first step is to create a system that can automatically detect the embryo. This paper proposed Random Sample Consensus (RANSAC) method based on Arc Segment to automatically detect embryo.From the experiment that have been conducted, the proposed method can detect single and multiple ellipse on embryo with a better accuracy than the previous method, EDCircles by 6% and 3% for single and double respectively
The Effect of Metformin and Cinnamon on Serum Anti-Mullerian Hormone in Women Having PCOS: A Double-Blind, Randomized, Controlled Trial
No full textBackground: Polycystic ovary syndrome (PCOS) is known to be associated with insulin resistance and anti-Mullerian hormone (AMH), leading to the use of insulin-sensitizing agents (ISAs) to manage PCOS. Metformin is the most widely used ISA to treat irregular menstruation; however, the gastrointestinal side effects are quite debilitating. The development of herbal medicines such as bioactive fraction DLBS3233 offers a possibly effective treatment with minimal side effects. Aim: To determine the effect of metformin and DLBS3233 on serum AMH level. Materials and Methods: This study was a double-blind, randomized, controlled trial conducted between March 2013 and June 2015 at Yasmin Clinic, RSCM Kencana, Jakarta and Hasan Sadikin Hospital, Bandung. The patients with PCOS were diagnosed using the Rotterdam criteria. All participants received daily treatment consisting of 1500 mg metformin divided into two doses or 100 mg DLBS3233 for 6 months. An evaluation of serum AMH level was conducted before and after the completion of therapy. Results: Twenty patients received metformin, whereas 18 patients received DLBS3233. The levels of AMH prior to the intervention were 9.30 ± 5.06 ng/mL and 11.27 ± 6.47 ng/mL. After 6 months of therapy, we found that the decrease in AMH level was higher in the metformin group compared to the DLBS3233 group (ΔAMH = 1.83 ng/mL, P = 0.003 and ΔAMH = 1.15 ng/mL, P = 0.077, respectively). However, more side effects were observed in the metformin group compared to the DLBS3233 group (P = 0.01). A total of seven patients (18.42%) were confirmed as pregnant during the study. Conclusion: There was a significant decrease in the serum AMH level after administration of either metformin or DLBS3233
Demand Readiness Level: Upaya Menembus Batas Inovasi Bidang Kesehatan di Era "New Normal"
No full text  
The Role of Dominant Follicular Diameter and LH in Predicting Ovulation in Cycle with Clomiphene Citrate
Full text linkObjective: To improve diagnostic method to predict ovulation in cycle with clomiphene citrate.
Method: This diagnostic research was done in RSUPN Dr. Cipto Mangunkusumo between January 2011 - October 2011 with 31 women who taking CC 50 mg/day and 30 women with normal cycle.
Result: Affecting with ovulation in the two groups, it was found that in groups with CC, the follicle diameter is 24.33 ± 3.87 mm with LH 14.21 ± 7.95 IU/l, meanwhile in normal group, follicular diameter is 17.62 ± 3.45 mm with LH 14.42 ± 5.91 IU/l. Cut-off point for follicular diameter simultaneously with ovulation determined by ROC curve was found in 24.33mm (AUC 0.67, sensitivity 0.64, specificity 0.56), meanwhile the cut-off for LH is 14.40 IU/l
(AUC 0.61, sensitivity 0.57, specificity 0.43).
Conclusion: In group with CC, ovulation occurred in bigger follicular diameter than normal cycle, while LH does not different significantly.
[Indones J Obstet Gynecol 2011; 35-3: 128-9]
Keywords: clomiphene citrate, follicular diameter, luteinizing hormon
Anti Mullerian Hormone Serum Level Indicates Ovarian Response in Controlled Ovarian Hyperstimulation of IVF Cycles
Full text linkObjective: To evaluate the clinical value of Anti Mullerian Hormone
serum (AMH) level as one of ovarian response indicator in
controlled ovarian hyperstimulation in IVF cycles.
Method: This cohort-prospective study was conducted in Dr.
Cipto Mangunkusumo General Hospital. The subjects of this study
were infertile couples who underwent controlled ovarian hyperstimulation in IVF cycles. The measurement of FSH level, estradiol level, AMH level, and antral follicles count was done in the beginning of IVF cycles. The cycles were divided into two groups, good
responder group and poor responder group. Good responder group
had three or more mature oocytes, while the poor responder group
had two or less mature oocytes. Statistical analysis was done using
T-Test and Receiver Operator Characteristic area under curve
(ROCAUC) to measure the predictive value of AMH, FSH, estradiol,
age, and antral follicle count as ovarian response predictors.
Results and Discussion: From 92 IVF cycles, there were 15
poor responder cycles (16.3%) and 77 good responder cycles. AMH
serum level was 3.75 ± 2.77 μg/ml in good responder cycles and
1.04 ± 1.39 μg/ml in poor responder cycles (p < 0.0001). AMH serum
level was more superior than other ovarian response predictors
(AUC 0.846) with cut-off value of 1.40 μg/ml. AMH serum level ≥
1.40 μg/ml had good predictive value as ovarian reserve or ovarian
reserve parameter with 81% sensitivity and 87% specificity.
Conclusion: AMH serum level was more superior ovarian reserve
and ovarian response predictor compared to other parameters.
[Indones J Obstet Gynecol 2010; 34-3: 114-8]
Keywords: anti-Mullerian hormone, ovarian reserve, ovarian
respons
Predictive Factors for Pregnancy in IVF: An Analysis of 348 Cycles
Full text linkObjective: To determine predictive factors for pregnancy after
IVF.
Method: The subject of this study were three hundred and forty
eight IVF cycles in 266 couples who underwent controlled ovarian
hyperstimulation in IVF cycles between January 2005 and March
2010. Categorical variables were compared using Chi Square test
and continuous variables were analyzed using Independent t-test, p
< 0.05 was considered statistically significant. Multivariate logistic
regression analysis was done to test correlations between clinical
variables and the occurrence of pregnancy.
Results: The women’s age significantly influenced pregnancy
rate since women under 35 years old has the best chance for pregnancy
(56.4%). Endometrial thickness on the day of hCG administration
also significantly influenced pregnancy in IVF (p < 0.001)
because 64.1% of pregnancy occurred if endometrial thickness ≥
10.95 mm. Serum FSH on 3rd day of period that can predict ovarian
reserve also has significance on pregnancy. On the other hand,
61.5% pregnancy occurred if more than 6 mature oocytes were retrieved
(p < 0.001). Among 92 patients of 348 cycles we found
strong correlation between AMH level with number of mature oocytes
retrieved (p < 0.001; r 0.659). Logistic regression done revealed
the couple with best chance of pregnancy can be described
as follows: women with endometrial thickness ≥ 10.95 mm, number
of mature oocytes > 6 and age under 35 years old.
Conclusion: This study enabled the characterization of many
prognostic factors for pregnancy.
[Indones J Obstet Gynecol 2010; 34-4: 180-4]
Keywords: in vitro fertilization, clinical pregnancy, age, mature
oocytes, endometrial thicknes
- …
