62 research outputs found
Pyridyl \u3cem\u3eBis\u3c/em\u3e-Urea Macrocycles as Supramolecular Synthons And the Design and Synthesis of Small Molecule Pharmaceuticals Targeting LY6K
No full textAssembled pyridyl bis-urea macrocycles have been utilized as 1D supramolecular synthons to construct hierarchical assemblies. These macrocycles have both urea and pyridyl functional groups and can form non-covalent interactions with hydrogen or halogen bond donors through symmetric, ditopic acceptor motifs. Bis-urea macrocycles offer interesting capabilities as synthons to organize donors into well-defined crystal structures. In part, this is due to the urea motifs’ propensity to assemble through hydrogen bonding. New, asymmetric pyridyl macrocycles were synthesized, crystallized, and experimentally probed to determine how symmetry affects their assembly and utility as supramolecular synthons.
The Uphadhyay group identified small molecules, including NSC11150, from the National Cancer Institute’s (NCI) library to bind lymphocyte antigen 6K (LY6K) protein by the. The LY6K protein has been implicated in the progression of several types of cancer. Docking simulations were performed on NSC11150, as well as several derivatives, to determine the binding mechanism to LY6K. NSC11150 was synthesized on a large scale and purified. Additionally, several derivatives of NSC11150 were synthesized in order to attach functional tags, such as D-biotin and BODIPY, for streptavidin binding assays or fluorescence microscopy, respectively
What's the problem?: Studies on identifying usability problems in user tests
No full textDuring the process of developing products difficulties in use (usability problems) are hard to predict. This especially holds for interactive products with embedded software. In user tests conducted during the design process analysts try to foresee which problems people will run into when using a product. Once they have identified and understood the problems, product developers may attempt to redesign the product so that the risk of users encountering usability problems will be minimized. Extracting usability problems from observed user behavior in a consistent manner has proven to be very difficult. Not only is it difficult for analysts to analyze all observations in the same way (this is called within-analyst consistency) but different analysts also tend to uncover different usability problems (across-analyst consistency). Within-consistency can be at stake when analysts become tired, less attentive or distracted during the analysis. Across-analyst consistency may also concern issues like differences in analysts' beliefs, values or preferences. In this thesis the focus is at consistency in identifying usability problems in user tests. The DEVAN (DEtailed Video ANalysis) procedure was developed to make such analyses documentable and inspectable. Next, DEVAN and its simplified variant SlimDEVAN were used in an academic setting and in a setting of professional usability labs. The aim was to determine to what extent (Slim)DEVAN exposes possible sources of inconsistency and manages to reduce inconsistencies caused by fatigue, lack of vigilance and distraction. In addition, DEVAN was applied to a comparative study in which the effect of using prototypes (instead of functioning products) in user tests is studied in detail. The thesis demonstrates how user test data analyses suffer from persistent inconsistencies. The use of (Slim)DEVAN allowed for detecting causes of persistent inconsistencies. In the comparative study the use of DEVAN revealed effects of using prototypes in user tests. For reducing less persistent inconsistencies advanced (automated) observation tools and more precise problem criteria are proposed. We suggest that further research should focus on consequences of inconsistencies in actual product development contexts. Eventually this will lead to more insight into the quality aspects of user tests, which in turn may lead to a decrease in the number of users muttering: "What's the problem? Why does this thing not do what I want it to do?"Industrial Design Engineerin
Modeling employment outcome post brain injury resource facilitation
No full textDisability following traumatic brain injury (TBI) can impact community integration as well as employment post injury. Considering the impact unemployment can have on quality of life, recovery, and the economy, several targeted interventions have been identified in the literature. One successful evidence-based intervention is called resource facilitation (RF). RF is an intervention targeted at improving employment rates in the TBI community with resulting return to work rates well above established return to work rates published in the brain injury population. Even with the success of RF, variability in outcome in a concern. Identification of variables that contribute to positive or negative employment outcomes could help target at-risk patients earlier in the treatment protocol and influence clinical recommendations during treatment. This project was designed to identify the complex relationship between predictor variables and return to work after participation in the RF program. Although many models exist currently in the literature, none of the published models are appropriate for the RF population. Additionally, currently published models typically involve linear regression models making the relationships between predictor variables difficult to detect. Structural equation modeling (SEM) was used to test the variables identified in the literature and identify direct and indirect predictors of outcome. SEM allows for direct testing of mediating variables as well as proposed latent variables within one prediction model. A preliminary model based on theoretical considerations as well as empirical evidence was used as a starting point. Although the initially hypothesized model was not an appropriate fit for the current dataset, two statistically sound models were generated during post hoc testing. Upon successfully identifying the two prediction models, results indicate that brain injury survivors with childhood injuries cannot be modeled in the same sample as brain injury survivors injured as adults, suggesting a difference between rehabilitation patients and “habilitation” patients.Ph.D.Includes bibliographical referencesby Devan Parrot
Privacy Issues and the Paparazzi
No full textIn order to understand the current statutes and their implication for privacy issues, Part I explores the history of the paparazzi and their invasion into the lives and privacy of celebrities as a safety concern. Part II reviews the history of both California Penal Code 11414 and California Civil Code 1708.8. Part III examines the text of California Penal Code 11414 and California Civil Code 1708.7, 1708.8, and 1708.9, as amended by the three bills. Part IV analyzes how the statutes as amended interact with the common law torts of intrusion and trespass and discusses how the statutes interact with the common law defenses of assumption of risk and waiver. Part V compares the current version of the California privacy statutes and how they compare to the developments taken in other states and countries. Part VI concludes the paper with a brief analysis of potential First Amendment arguments against the statute.
This abstract has been taken from the author\u27s introduction
Recommended from our members
Privacy Issues and the Paparazzi
No full textIn order to understand the current statutes and their implication for privacy issues, Part I explores the history of the paparazzi and their invasion into the lives and privacy of celebrities as a safety concern. Part II reviews the history of both California Penal Code 11414 and California Civil Code 1708.8. Part III examines the text of California Penal Code 11414 and California Civil Code 1708.7, 1708.8, and 1708.9, as amended by the three bills. Part IV analyzes how the statutes as amended interact with the common law torts of intrusion and trespass and discusses how the statutes interact with the common law defenses of assumption of risk and waiver. Part V compares the current version of the California privacy statutes and how they compare to the developments taken in other states and countries. Part VI concludes the paper with a brief analysis of potential First Amendment arguments against the statute.
This abstract has been taken from the author\u27s introduction
Privacy Issues and the Paparazzi
No full textIn order to understand the current statutes and their implication for privacy issues, Part I explores the history of the paparazzi and their invasion into the lives and privacy of celebrities as a safety concern. Part II reviews the history of both California Penal Code 11414 and California Civil Code 1708.8. Part III examines the text of California Penal Code 11414 and California Civil Code 1708.7, 1708.8, and 1708.9, as amended by the three bills. Part IV analyzes how the statutes as amended interact with the common law torts of intrusion and trespass and discusses how the statutes interact with the common law defenses of assumption of risk and waiver. Part V compares the current version of the California privacy statutes and how they compare to the developments taken in other states and countries. Part VI concludes the paper with a brief analysis of potential First Amendment arguments against the statute.
This abstract has been taken from the author\u27s introduction
The Perceived Value of Acquiring Data Seals of Approval Study Dataset and Associated Files
No full textThis package contains the data and associated analyses for a study which examined the benefits of acquiring Data Seals of Approval (DSAs) from the point of view of those who have them. This package includes data from a series of 15 semi-structured interviews with representatives from 16 different organizations in which participants described the benefits of having DSAs in their own words. The four files in this package include: 1) the coded interview transcripts and description of codes (i.e., codebook) in NVivo for Mac Version 11.3.2 (1888) file format (e.g., .nvpx), 2) the raw dataset that lists the frequency with which each benefit was mentioned by DSA board members and non-DSA board members in IBM SPSS Statistics 24 file format (e.g., .spv), and 3) the processed/analysed data from the Mann-Whitney U tests in two different file formats (e.g., .doc and .spv).This project was funded by a Research Data Alliance United States Data Share Fellowship from the Alfred P. Sloan Foundation.This study investigates the value of acquiring DSAs from the perspectives of those who have them. To avoid data collector characteristics and bias that could potentially affect what data were collected and how they were analysed, only those without prior experience in the development of the DSA were selected to be a part of the research team that handled data collection and analysis. Specifically, this study included a data collector who is knowledgeable about repository standards but yet did not play an active role in the development of any of them. The data collector also does not serve as a formal third-party auditor, a contrast from existing research on this topic. Approval for conducting this research was received from the Indiana University Human Subjects Office.
Our findings are drawn from data collected during interviews conducted between August 2015 and February 2016. All participants were at organizations whose repositories successfully acquired DSAs. We selected these individuals because only digital repository staff members at institutions which successfully acquired DSAs would be able to speak from experience about the actual benefits of having them. The list of 64 acquired seals on the DSA website constituted the sampling frame. The first author recruited participants by emailing representatives from each of the repositories that acquired the DSA and inviting their participation. The first author sent follow-up emails on two separate occasions to try to increase participation. As a result of these efforts, we successfully recruited 15 representatives from these repositories to participate in this study, with a response rate of 23%.
The primary purpose of conducting the semi-structured, 30-minute interviews was to understand the value of the audit process and certification from the perspective of actual digital repository staff members. The first author asked respondents to discuss: how they learned about the DSA certification, how they decided to undergo audit, how they prepared for it, what the process was like, any lessons learned, the perceived value of the audit process, and the perceived value of certification since attaining it. No incentives for participation were provided.
All interviews took place by telephone or via Skype and were audio recorded. Afterwards, all interviews were transcribed. Transcripts were then coded using NVivo – a qualitative data analysis software tool. Prior to analyzing the transcripts, the first author developed a codebook based primarily on the list of benefits on the DSA website. The first author also remained open to identifying additional themes as a result of analyzing the transcripts. The first author and a hired graduate student coded the transcripts. We calculated inter-rater reliability using Cohen’s Kappa. We achieved a score of 0.87; thus, on average, we agreed on codes 87% of the time.
Some participants played an active role in the development of the DSA, either as past or present DSA board members. This was seen as a potential threat to the validity of the data. In particular, DSA board members could subconsciously or consciously over-report the benefits of acquiring DSAs based on their knowledge of and experience with the standard. For this reason, additional data analyses were performed. Specifically, a series of Mann-Whitney U tests were performed to detect whether any statistically significant differences existed between DSA board members and non-DSA board members regarding the frequency with which they reported benefits of acquiring DSAs. All statistical analyses were performed using IBM SPSS Statistics 24.To access the coded interview transcripts and description of codes (i.e., codebook), you need NVivo for Mac Version 11.3.2 (1888). To access the raw dataset that lists the frequency with which each benefit was mentioned by DSA board members and non-DSA board members, you need IBM SPSS Statistics 24. To access the processed/analysed data from the Mann-Whitney U tests, you need IBM SPSS Statistics 24 to access the .spv file and Microsoft Word to access the .doc file
Feminismo en la poesía de Claribel Alegría
No full textDate on title page reads 5/22/2010 - author verifies typo and correct date to be 5/22/2014.Claribel Alegría is an important Central American essayist, novelist, poet, and feminist. She was born in Nicaragua, and then raised in El Salvador because of the exile of her parents by the dictator, Anastasio Somoza Debayle. During her childhood she was influenced by the deaths and disappearances of many Nicaraguans during the Somoza dictatorship as well as the aftermath of the massacre of over 30,000 peasants in El Salvador. These violent and turbulent events inspired her writing. Many scholars have analyzed and celebrated her most famous novels for their political and social commentaries; however few have investigated her poetry. My research gives a more complete picture of the works of Claribel Alegría through the analysis of five books of her poetry. This investigation revealed that Claribel Alegría not only deals with themes of social and political justice, but also themes of feminism. In her poetry she questions the official history, and instead demonstrates events through a woman’s lens, criticizes traditional gender roles in both the public and private spheres, and changes images of women in famous literary works to empower them and treat them as literary subjects, instead of literary objects.SUNY BrockportModern Languages and CulturesSenior Honors These
ON THE NA’T GHAZALS OF ABDURAHMAN JAMI AND ALISHER NAVAI
No full textThe article deals with a comparative study of na’t ghazals of the great figures of the Persian and Turkic poetry – Abdurahman Jami and Alisher Navois’ Devans. The ghasals play an important role for the evaluation of the XV century’s religious-philosophical and artistic thinking. In Alisher Navoi\u27s ‘Khazoyin ul-maoni’, which consists of four devan and n’at ghazals of A. Jami’s three devans, which deals with the subject-matters about Muhammad (s.a.v)’s lifestyle , khadises, miracles sent to him and his role in the life of a human being have been stated. Author analyzes the na’ts by both poets’ ghazals, in particular the subject of the artistic knowledge of several images and concepts: Mecca, Batho, Ka\u27ba, Medina, Yasrib, Zamzam, Prophethood, Adam, Khatam al-Anbiya, Hadisand others. According to the placement of na’t ghazals of A. Navai’s devan, the author emphasizes that they have a stable arrangement in the composition of devons, unlike of A. Jami’s ghazals, which is linked with ‘Shawahid un- Nubuwat’, the life-style of the Prophet Muhammad
Acquisitions et services bibiiographiques
No full textcanada canada The author has granted a nonexclusive licence aiiowing th
- …
