1,229 research outputs found
Practical Application of the 3Rs in Rodent Transgenesis
No full textThe principles of the 3Rs (replace, reduce, refine), as originally published by Russell and Burch, are internationally acclaimed guidelines for meeting ethical and welfare standards in animal experimentation. Genome manipulation is a standard technique in biomedical research and beyond. The goal of this chapter is to give practical advice on the implementation of the 3Rs in laboratories generating genetically modified rodents. We cover 3R aspects from the planning phase through operations of the transgenic unit to the final genome-manipulated animals. The focus of our chapter is on an easy-to-use, concise protocol that is close to a checklist. While we focus on mice, the proposed methodological concepts can be easily adapted for the manipulation of other sentient animals
Identiteter och världsbild : "hårdkokt" skriftbruk i Thorsten Jonssons noveller
No full textidentity and worldview – “hard-boiled” writing in Thorsten Jonsson’s short storiesThis article deals with the Swedish author Thorsten Jonsson (1910–50) and his first short story collection Som det brukar vara (1939) [‘As it usually is’]. The nar- rative represents a new modernistic literary trend in Swedish prose in the 1930s. i take my starting point in Burgess & ivanič’s (2010) theories of the act of writing involving many different identities, and particularly what Burgess & ivanič iden- tify as the discursive self. By contemporary readers and critics the discursive self in the short story collection was often connected with an American hard-boiled literary ideal, often linked to ernest Hemingway’s writings. in this article i dis- cuss the common textual features of the two authors’ first collections, but also the differences that emerge when looking through the linguistic surface. The analysis shows that Thorsten Jonsson’s discursive self is based upon a northern Swedish culture, Hemingway’s on an urban American one. </p
Measures of excess liquidity
Full text linkThe aim of this note is to provide an overview of various measures of excess liquidity, which can be defined as the deviation of the actual stock of money from an estimated equilibrium level. Given their dynamic nature, the excess liquidity measures under review are - in the light of long and variable lags of monetary policy - very useful tools to quantify future price pressures. In addition, excess liquidity measures consider inflation as a purely monetary phenomenon: neither the output gap nor liquidity gap - although both form an integral part of the concepts - an be held responsible for inducing a persistent rise in the price level. Despite strong theoretical support, the usefulness of excess liquidity measures depends on the stability of money demand, a question which has of course to be answered in the realm of empirical research. --P-star,excess liquidity,monetary policy,ECB
Beginnt die neue Arbeitswelt mit einer Abwesenheitsnotiz?
Full text linkWomit und wann fängt die neue Arbeitswelt an? Indem wir das Büro verlassen? Wie und wo wollen wir künftig arbeiten und welche Werkzeuge benötigen wir dafür? Microsoft Deutschland lebt die neue Arbeitswelt mit seinen flexiblen Arbeitsmodellen und der offenen Unternehmenskultur bereits seit vielen Jahren und hat mit dem Manifest für neues Arbeiten vor einem Jahr die Diskussion um die Wissensarbeit der Zukunft angestoßen. Mit dem Buch „Out of Office – Warum wir die Arbeit neu erfinden müssen“ findet diese Debatte nun ihre Fortsetzung. "Wir haben dieses Buch mit der Absicht verfasst, die Büroarbeit der Zukunft neu zu definieren,", so die Autoren Dr. Elke Frank, Personalchefin bei Microsoft Deutschland und Dr. Thorsten Hübschen, verantwortlich für das Office Geschäft. "Out of Office" erscheint im Redline-Verlag und ist ab sofort im Handel erhältlich
Beginnt die neue Arbeitswelt mit einer Abwesenheitsnotiz?
No full textWomit und wann fängt die neue Arbeitswelt an? Indem wir das Büro verlassen? Wie und wo wollen wir künftig arbeiten und welche Werkzeuge benötigen wir dafür? Microsoft Deutschland lebt die neue Arbeitswelt mit seinen flexiblen Arbeitsmodellen und der offenen Unternehmenskultur bereits seit vielen Jahren und hat mit dem Manifest für neues Arbeiten vor einem Jahr die Diskussion um die Wissensarbeit der Zukunft angestoßen. Mit dem Buch „Out of Office – Warum wir die Arbeit neu erfinden müssen“ findet diese Debatte nun ihre Fortsetzung. \"Wir haben dieses Buch mit der Absicht verfasst, die Büroarbeit der Zukunft neu zu definieren,\", so die Autoren Dr. Elke Frank, Personalchefin bei Microsoft Deutschland und Dr. Thorsten Hübschen, verantwortlich für das Office Geschäft. \"Out of Office\" erscheint im Redline-Verlag und ist ab sofort im Handel erhältlich
A case for money in the ECB monetary policy strategy
Full text linkOne major outcome of the review of the ECBs two pillar monetary policy strategy, which was published on 8 May 2003, has been the de facto downgrading of the hitherto prominent role assigned to the stock of money. According to the authors judgement, however, there is a strong theoretical and empirical rationale for the ECB monetary policy to pay close attention to the information content of money in the form of M3. However, the authors argue the ECB should make use of the so-called price gap or real money gap concept rather than the reference value as the latter runs the risk of giving misleading policy recommendations and compromising the indicator quality of the stock of money. Making use of M3 seems all the more rational as currently no better inflation indicator appears to exist in providing inflation forecasts in the euro area. --P-star,real money gap,excess liquidity,ECB
Why is unemployment so high in Bulgaria?
Full text linkThe author seeks to determine the main factors behind poor labor market outcomes in Bulgaria. Unemployment in Bulgaria is high and of long duration. The accumulation of the unemployment stock has been caused by relatively high inflows into unemployment coupled with limited outflows. These features of the Bulgarian labor market are typical of other transition economies in Central Europe and exploring their sources is of broad interest. The author focuses on determinants of and constraints to job creation. He uses data on job creation and job destruction from a survey of employment in all registered firms. He finds that the source of large inflows into unemployment is intensive enterprise restructuring associated with a high pace of job reallocation. However, job creation falls short of job destruction. Three main factors account for the limited job creation and hiring, and thus for low outflows from unemployment: a) The unfriendly business environment, reflected by a low rate of new firm formation, and a relatively small, small and medium enterprise sector. b) Labor market rigidities, including excessive hiring and firing costs. c) Skill and spatial mismatches brought about by enterprise restructuring, as well as low skills and marginalization of the long-term unemployed who cannot successfully compete for new jobs. The author recommends a three pronged strategy to improve labor market performance: (1) removing bureaucratic constraints to entry and expansion of firms; (2) enhancing labor market flexibility through lowering hiring and firing costs; and (3) improving the educational system so as to equip workers with broad and portable skills.Environmental Economics&Policies,Labor Policies,Labor Markets,Public Health Promotion,Health Monitoring&Evaluation,Environmental Economics&Policies,Labor Markets,Health Monitoring&Evaluation,Labor Standards,Banks&Banking Reform
The impact of taxation on upper and lower bounds of enterprise value
Full text linkBraun T. The impact of taxation on upper and lower bounds of enterprise value. Discussion paper / Fakultät für Wirtschaftswissenschaften, Universität Bielefeld. Bielefeld: Universität Bielefeld; 2005.This paper derives and draws on simple formulae for the upper and lower bounds to the value of a series of risky cash flows in order to provide some instructive insights in the impact of taxation on these bounds.
The formulae are based on no-arbitrage conditions in a setting that is a straightforward extension of the Cox, Ross, and Rubinstein option-pricing model to an incomplete market model and look exactly like the popular Gordon growth formula.
Although based on stylized facts concerning the tax scheme the results promise to be a reliable guide for further research in this field
Improvements to the Secure Construction and Utilization of Greedy Embeddings in Friend-to-Friend Overlays
Full text linkRouting based on greedy network embeddings enables efficient and privacy-preserving routing in overlays where connectivity is restricted to mutually trusted nodes. In previous works, we proposed security enhancements to the embedding and routing procedures to protect against denial-of-service attacks by malicious overlay participants. In this work, we propose an improved timeout scheme to reduce the stabilization overhead of secure tree maintenance in response to node failures and malicious behavior. Furthermore, we present an attack-resistant packet replication scheme that leverages alternative paths discovered during routing
Living with Wolves
Full text linkWith their return to Germany, wolves leave their traces in personal feelings, in the atmospheres of rural landscapes and even in the sentiments and moods that govern political arenas. Thorsten Gieser explores the role of affects, emotions, moods and atmospheres in the emerging coexistence between humans and wolves. Bridging the gap between anthropology and ethology, the author literally walks in the tracks of wolves to follow their affective agency in a more-than-human society. In nuanced analyses, he shows how wolves move, irritate and excite us, offering answers to the primary question: What does it feel like to coexist with these large predators
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