305,664 research outputs found
IL TRATTAMENTO CHIRURGICO DELLE NEOPLASIE VESCICALI INFILTRANTI
No full textIL TRATTAMENTO CHIRURGICO DELLE NEOPLASIE VESCICALI INFILTRANT
Prostate cancer: Lymph node metastases: not always the same prognosis
No full textIn a recently published paper, Touijer and colleagues1 showed that pathological Gleason score, as well as the number of positive nodes, was significantly correlated with prostate cancer outcome in one of the largest retrospective series of node-positive patients treated with radical prostatectomy without adjuvant therapy (369 consecutive patients). In particular, the Gleason score and the number of positive nodes were important predictors of metastasis-free and biochemical-relapse (BCR)-free survival on multivariate analysis
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
PSMA PET/CT to stage high-risk prostate cancer: Is already the time to replace conventional imaging?
No full textCOMPLICANZE E MORTALITÀ PERIOPERATORIE DELLA CISTECTOMIA RADICALE: ANALISI RETROSPETTIVA UTILIZZANDO UNA CLASSIFICAZIONE STANDARDIZZATA
No full textHow can mpMRI help surgical planning in high risk prostate cancer?
No full textMultiparametric magnetic resonance imaging (mpMRI)represents nowadays an essential tool to guide radicalprostatectomy (RP). Despite nerve sparing (NS) approachwas traditionally precluded in high risk prostate cancer(HRPC) patients, Kumar et al. [1] suggested that a selectiveNS could be feasible even in HRPC patients with acceptablepositive surgical margins (PSMs) rates. Of note, accuratepreoperative selection of ideal candidates to NS surgery,especially in HRPC [2], is key. For this reason, we readwith interest the article by Baack et al. [3], thought theinnovative way of retrospective survey, the authors eval-uated the impact of mpMRI on surgical plan in HRPC bothconsidering NS approach, pelvic lymph node dissection(PLND) template, bladder neck approach and surgicaltechnique. They found that all patients had at least onechange to their surgical plan by urologists. Interestingly,considering the NS technique, the authors found that NSapproach was changed in 58% of cases with overallappropriateness of 72%, which is consistent with our pre-vious data with overall change in roughly 50% of cases,resulting an overall appropriateness of 75% [4]. This paperconfirms the important role of mpMRI even in HRPC inwhich NS approach is usually not considered for higher riskof extracapsular extension, suggesting that in selective casesof HRPC an incremental NS approach could be oncologi-cally safe only with a preoperative mpMRI.However, one important limitation is the lack of com-parison between the intended approach from the survey andthe real surgical plan performed during surgery. As weknow, the preoperative intended surgical plan (even afterrevision of mpMRI) could go through some modifications during surgery. Moreover, the definition of appropriatenessof the surgical plan change (defined as presence of extra-prostatic extension at pathologic specimen) is not ideal,since it considers only thefirst surgical outcomes of roboticRP (moreover it does not consider the presence of PSMs)rather than a real oncologic outcome (i.e. biochemicalrecurrence) or the postoperative erectile function.One more important aspect the authors underline is thepotential role of mpMRI to impact the PNLD template,suggesting that the use of mpMRI can modify the surgicalextension of PLND. We believe that an accurate mpMRI isuseful to investigate both the local stage of PC and the nodaland skeletal status within the pelvis, which is the mostcommon andfirst site of dissemination. Moreover, the PCcharacteristics detected at mpMRI, combined with clinicaldata, have the potential to influence surgeon during PLND.In fact, Gandaglia et al. [5] found that the information frommpMRI (i.e clinical stage at mpMRI, grade group at MRI-targeted biopsy and maximum size of index lesion) canimprove the accuracy of Briganti’s nomogram to predict thepresence of nodal metastases in patients with PC detected atMRI-targeted biopsy. Of course, further studies are neededto evaluate the role of mpMRI for both preoperative plan-ning of NS approach and the decision when to perform orhow to modify the template of PLND
Nuove tecniche di imaging in uro-oncologia: cosa è mito e cosa è realtà?
No full textLe tecniche di imaging accompagnano sempre più l’uro-oncologo in tutte le sue fasi decisionali. Le nuove
tecniche disponibili oggi sono in grado di cambiare la strategia terapeutica in molti ambiti, mentre in altri
non è chiaro ancora il loro reale impatto clinico. Per le piccole masse renali e testicolari l’imaging, insieme
alla caratterizzazione istologica, ha notevolmente contribuito a cambiare la strategia terapeutica.
Nella diagnosi e nella stadiazione del carcinoma prostatico la PET/CT e la risonanza magnetica MR multiparametrica
rappresentano metodiche d’avanguardia, ma il reale impatto clinico e il costo/beneficio non
sono ancora completante definiti, essendo spesso sovrautilizzate. Il presente corso si prefigge di affrontare
i topics attualmente di maggiore interesse nell’ambito della diagnostica uro-oncologica e di trattare
le principali problematiche cliniche in una prospettiva multidisciplinare
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
RIASSEGNAZIONE CHIRURGICA DEL SESSO IN TRANSESSUALISMO ANDRO-GINOIDE: EVOLUZIONE DELLA TECNICA CHIRURGICA E COMPLICANZE A MEDIO E LUNGO TERMINE
No full textRIASSEGNAZIONE CHIRURGICA DEL SESSO IN TRANSESSUALISMO ANDRO-GINOIDE: EVOLUZIONE DELLA TECNICA CHIRURGICA E COMPLICANZE A MEDIO E LUNGO TERMIN
Surgical treatment for pelvic bone metastases.
No full textThe pelvis is the second most common site of bone metastases after the spine. Pain, bone destruction causing mechanical instability and pathological fractures are the most common manifestations. Traditional treatments for pelvic bone metastases include surgery and external beam radiation therapy. If bone destruction is limited, analgesics, radiation therapy, hormonal therapy, chemotherapy, embolization, bisphosphonates and minimally invasive techniques such as radiofrequency ablation, osteoplasty and cryosurgery can be considered [6]. Lesions of the hemipelvis not directly involving the hip joint, pathological fractures sustained through an area of the pelvis other than the acetabulum and avulsion fractures of the anterior superior/inferior iliac spines, iliac crest and pubic rami seldom require surgical stabilization and reconstruction because pelvic stability is maintained. By contrast, diffuse involvement of the pelvis, impending or existing pelvic discontinuity and bony destruction of the periacetabular area warrants surgical treatment [4,7–10]. The use of poly(methyl methacrylate) to bridge large defects and suspend an acetabular component, conventional total hip replacement, massive allograft or saddle megaprosthetic reconstruction are likely to fail because of the deficient bone and the progressive osteolytic disease [1]
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