17,230 research outputs found
Functional Analysis of the Chemokine Receptor CCR3 on Airway Epithelial Cells
No full textThe function of chemokine receptors on structural cells is only partially known. We previously reported the expression of a functional CCR3 receptor on airway epithelial cells (EC). We speculated that CCR3 might drive wound repair and expression of inflammatory genes in epithelium. The human airway EC lines BEAS-2B, 16-HBE, and primary bronchial EC were used to test the effect of in vitro challenge with the CCR3 ligands CCL11/eotaxin, CCL24/eotaxin-2, or CCL26/eotaxin-3 on 1) wound repair, using an established wound model; 2) cell proliferation and chemotaxis, using specific fluorometric assays; and 3) gene expression, using pathway-specific arrays for inflammatory and profibrotic cytokines, chemokines, and chemokine receptor genes. Agonist specificity was tested by cell pretreatment with an AstraZeneca CCR3 antagonist (10(-8) - 10(-6) M). CCL24 challenge significantly accelerated epithelial wound closure, with similar effects exerted by CCL11 and CCL26. This effect was time dependent, submaximal at 1 nM, and comparable in potency to epidermal growth factor. CCL24 induced a concentration-dependent increase in EC proliferation and chemotaxis, with significant effects observed at 10 nM. The AstraZeneca compound selectively inhibited these CCL24-mediated responses. CCL11 induced the up-regulation of several profibrogenic molecules such as fibroblast growth factor 1 and 5 and of several CC and CXC chemokines. Epithelial immunostaining for CCR3 was stronger in bronchial biopsies of asthmatics displaying marked inflammatory changes than in nondiseased samples. Epithelial CCR3 participates in key functions for wound repair, amplifies the expression of profibrogenic and chemokine transcripts, and appears up-regulated in inflamed asthmatic airways
The Story of "Me" Contemporary American Autofiction
No full textCover -- Title Page -- Copyright Page -- Contents -- Acknowledgments -- Introduction -- 1. Masculinity, Whiteness, and Postmodern Self-Consciousness -- 2. Rage against the Dying of the Author -- 3. The New Journalism as the New Fiction -- 4. Trauma Autofiction, Dissociation, and the Authenticity of "Real" Experience -- 5. Memoir vs. Autofiction as the Story of Me vs. the Story of "Me" -- Coda -- Appendix -- Notes -- References -- IndexDescription based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Remember Me A Novella about Finding Our Way to the Cross
No full textShades of Light.Cover -- Title Page -- Copyright -- Dedication Page -- Contents -- 1 The Word Became Flesh -- 2 The Gift of Myrrh -- 3 Taking the Cup -- 4 With a Kiss -- 5 Awakened -- 6 Accused -- 7 Bearing the Cross -- 8 Lament -- 9 Stripped -- 10 Pierced -- 11 It Is Finished -- 12 Into Your Hands -- 13 Buried -- 14 Risen -- Epilogue -- Journey to the Cross -- Acknowledgments -- Also Available -- Praise for Remember Me -- About the Author -- More Titles from InterVarsity PressShades of Light.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes.
No full text"Test me and treat me" - attitudes to vitamin D deficiency and supplementation: a qualitative study
No full text© 2015 BMJ Open, "Test me and treat me"-attitudes to vitamin D deficiency and supplementation: a qualitative study. This manuscript version is made available under the Creative Commons Attribution Licens
Book of the month: Kennetta Hammond Perry's London is the Place for Me
No full textAuthor: Desmond L. Kemp Indiana University Purdue University Our book recommendation of the month is London is the Place for me whereby activism in London and America has been an ongoing challenge for Black people. Perry delivers a solid account of how post-war Afro-Caribbean migrants resisted British racism to establish their citizenship in England. The introduction begins with a calypso music tribute in "Windrush Politics", sets the tone of social history for migrants with a tale of the arr..
Basa Village Project
No full textJeff Rasley - author of several books (including Monsters of the Doorway, Light in the Mountains, a thriller titled False Prophet, Islands in My Dreams, and Bringing Progress to Paradise) about combining adventure travel with philanthropy. Jeff practiced law in the Indianapolis (US) region for 30 years and is currently the partner of Knowledge Capture Publishing and Editing as well as the president of the Basa Village Foundation. Amazingly he is also able to act as a liaison for Adventure Geo-Treks LTD, while teaching students. We’ll learn all about this today, but before we do let me give you his website information now…
Find today’s guest at: http://www.JeffreyRasley.com and you can find the hosts at: http://Brummet.c
Remind Me to Investigate
No full textPolitical cartoon depicting United States Senator James O. Eastland of Mississippi dictating to his secretary, Remind Me to Investigate the Ole Miss Affair, My Findings Will Be as Follows; Source: unknown; Unknown datehttps://egrove.olemiss.edu/jws_clip/1054/thumbnail.jp
Dynamics of Network Formation Processes in the Co-Author Model
No full textThis article studies the dynamics in the formation processes of a mutual consent network in game theory setting: the Co-Author Model. In this article, a limited observation is applied and analytical results are derived. Then, 2 parameters are varied: the number of individuals in the network and the initial probability of the links in the network in its initial state. A simulation result shows a finding that is consistent with an analytical result for a state of equilibrium while it also shows different possible equilibria.Dynamics, Network, Game Theory, Model,Simulation, Equilibrium, Complexity
- …
