188,711 research outputs found
Association between polymorphisms and oxidative stress genes in patients with common complex diseases
No full textAvtoimune kompleksne bolezni, kot so kronična vnetna črevesna bolezen, multipla skleroza in astma, nastanejo kot posledica delovanja genetskih in okoljskih dejavnikov. Pomembno vlogo pri nastanku teh bolezni ima oksidativni stres, saj poveča vnetje, sproži apoptozo celic ter zniža imunsko odpornost. Diplomsko delo prikazuje vpliv sprememb v genih oksidativnega stresa na razvoj astme, multiple skleroze in kronične vnetne črevesne bolezni v slovenski populaciji.
V diplomskem delu smo pri slovenskih bolnikih z astmo, multiplo sklerozo in kronično vnetno črevesno bolezenijo ter pri kontrolni skupini zdravih posameznikov s tehniko talilne krivulje visoke ločljivosti genotipizirali polimorfizme posameznega nukleotida (SNP) v genih oksidativnega stresa, in sicer SNP rs4880 na genu SOD2 in SNP rs2107538 na genu CCL5.
Ugotovili smo statistično značilno povezavo med polimorfizmom SNP rs4880 na genu SOD2 in multiplo sklerozo. Pri bolnikih z multiplo sklerozo je bila frekvenca alela C višja (0,559) v primerjavi s kontrolno skupino (0,471, p=0,019). To pripišemo izgubi funkcije MnSOD, do katere pride zaradi zamenjave timina s citozinom na 47. mestu. Povezave med rs2107538 na genu CCL5 in analizirami boleznimi nismo potrdili.
Ugotovili smo, da SNP rs4880 na genu oksidativnega stresa SOD2 prispeva k patogenezi multiple skleroze in prav tako nakazuje na povezavo z razvojem astme. Rezultati diplomskega dela nakazujejo na vlogo genov oksidativnega stresa pri nastanku kompleksnih bolezni.Autoimmune complex diseases, such as chronic inflammatory bowel disease, multiple sclerosis and asthma, develop as a result of genetic and environmental factors. Oxidative stress has an important role in the development of these diseases as it increases inflammation, triggers apoptosis and weakens the immune system. Diploma thesis demonstrates influence of damaged oxidative stress genes on the development of asthma, multiple sclerosis and chronic inflammatory bowel disease in Slovenian population.
In diploma we genotyped single nucleotide polymorphisms (SNP) rs4880 on SOD2 gene and rs2107538 on CCL5 gene, with a high resolution melting technique on patients with asthma, multiple sclerosis and chronic inflammatory bowel disease in Slovenian population.
We found a statistically significant correlation among SNP rs4880 on SOD2 gene and multiple sclerosis. Multiple sclerosis patients had a higher allele C frequency (0,559) in comparison to control group (0,471, p=0,019). The cause of MnSOD function loss was attributed to thymine swap with cytosine on 47th nucleotide. There is no noticeable connection among rs2107538 and any of the diseases.
We discovered that SNP rs4880 on SOD2 gene contributes to MS pathogenesis, as well as connection to the development of asthma. Results of the diploma thesis represent that genes of oxidative stress play a significant role in the development of complex diseases
Supplementary Data for "Accumulation of radiocarbon in ancient terrestrial landscapes: A small but significant input of unknown origin"
No full textThis study examined the organic carbon content of ~28-33 Ma paleosols. The files in this data set include the raw TG-DSC-EGA data generated with a laboratory instrument, and serve as supplemental materials to the corresponding manuscript. Thermal and Evolved Gas Analysis raw data for two paleosol samples (Luca and Kskus pedotypes from Retallack et al. 2000) are reported here. A Setaram Labsys Evo differential scanning calorimeter (DSC) / thermal gravimeter (TG) connected to a Pfeiffer Omnistar quadrupole mass spectrometer (QMS) was configured to operate similarly to the SAM evolved gas analyzer. The SAM instrument does not have TG/DSC capabilities, but these components permit a better understanding of phase transitions and chemical reactions in laboratory experiments. Approximately 50 mg ± 3 mg of ground paleosol sample were placed in an Al2O3 sample crucible. The sample crucible and an identical empty reference crucible were placed in the furnace and then the system was purged twice with helium gas and set to a pressure of 30 mbar. Helium was chosen as a carrier gas because it is inert and because it used as a carrier gas in the SAM instrument. The crucibles were heated from approximately 35 °C to 1000 °C at a heating rate of 35°C/min and at a flow rate of 10 sccm. Volatiles ranging from mass/charge (m/z) 1 - 100 were measuredRetallack, G.J., Bestland, E.., and Fremd, T.., 2000, Eocene and Oligocene Paleosols of Central Oregon: Geological Society of America Special Paper, v. 344, p. 1–192, doi:10.1046/j.1365-3091.2001.0394c.x
The Cult of Personality of Josip Broz Tito
No full textA cult of personality is an eternally relevant historical and social topic. This
paper will showcase the main elements of the cult of personality of Josip Broz
Tito, the leader of Yugoslavia, and one of the most prominent historical figures
in general. The meaning of the term ‘’cult of personality’’ will be explained, as
well as the main elements that led to its establishment. Some of the elements,
which were approved by most of the population of Yugoslavia and used for the
establishment of Tito’s untouchable reign, will also be provided, as well as the
ways in which they were used to achieve said reign
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A simple new hydrazine-free synthesis of methyl 1,4,5-trisubstituted 1H-pyrazole-3-carboxylates
No full textConditions for successful syntheses of poly-
substituted pyrazole-3-carboxylates have been found. The
methodology consists in mixing equimolar amounts of
diazonium tetrafluoroborates and enaminoesters in pres-
ence of sodium acetate. 1-Methylpyrrolidone has appeared
to be the solvent of choice. The compounds prepared have
been characterized by means of nuclear magnetic reso-
nance (NMR) spectroscopy, elemental analysis, and in two
cases, also by X-ray diffraction. The advantage of the
methodology is a simple implementation without necessity
of working under inert atmosphere. The presence of other
functional groups enables further synthetic transformations
of the products
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Dr. Edward P. Wimberly, ITC, July 2011
No full textThis video is a conversation with Dr. Edward P. Wimberly. Dr. Wimberly talks about his book, "No Shame in Wesley's Gospel: A Twenty-First Century Pastoral Gospel". Brad Ost, AUC Woodruff Library, is the interviewer
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