1,720,974 research outputs found
Epigenetic regulation of the 4q35 subtelomeric locus and contribution of the D4Z4 macrosatellite in FSHD
No full textTroisième dystrophie musculaire en terme d’incidence, la dystrophie facio-scapulo-humérale est une maladie qui reste encore énigmatique. Bien qu’elle a été montrée comme associée à la contraction d’un macrosatellite, D4Z4, au niveau du subtélomère 4q35 au début des années 1990, l’origine des modifications observées chez les patients est encore mal connue. C’est pourquoi nous nous sommes intéressés à différents aspects de la pathologie. Tout d’abord, nous avons étudié l’expression des gènes de la région 4q35 ainsi que de gènes impliqués dans la physiologie musculaire chez des fœtus et des adultes porteurs ou non d’une contraction du nombre de D4Z4 et avons ainsi pu mettre en évidence que les dérégulations géniques étaient déjà observable chez les fœtus, faisant de ceux-ci un modèle relevant d’étude de la pathogénèse précoce de la FSHD. Nous nous sommes ensuite intéressés à la régulation épigénétique de deux gènes situés au niveau du locus 4q35 et avons pu observer que des modifications épigénétiques globales pouvaient, ou non, moduler l’expression de ces gènes et ce dépendamment du nombre de répétitions du macrosatellite. Enfin, nous avons analysé la régulation de la région par l’effet de position télomérique et avons remarqué que seuls certains gènes de la région, distants, étaient régulés par ce mécanisme épigénétique. Ces résultats nous ont permis d’avancer un peu plus dans la connaissance de la dystrophie facio-scapulo-humérale et de valider un nouveau modèle d’étude de la pathologie.Hird more frequently myopathy, the facioscapulohumeral dystrophy is an enigmatic disease. It is associated with the macrosatellite D4Z4 contraction since 90’s but the origin of the modifications observable in patients remains unclear. That’s why, we have focused our work in different aspects of this disease. First of all, we have studied expression of 4q35 and muscular genes in fetuses and adults carrying a contraction of the D4Z4 macrosatellite and shown that the molecular deregulations can be observed since the fetal stage. So, we have validated this model as an interesting model to study the early FSHD pathogenesis. Secondly, we have been interested in epigenetic regulation of two genes located in the 4q35 region and have observed a modulation of their expression in a global epigenetic modulation contest. Those deregulations depend on the number of D4Z4 repeats. Finally, we have analyzed the region regulation by telomere position effect and have noted only some genes are deregulated by this epigenetic mechanism. With those results, we have progressed in the FSHD pathogenesis knowledge and we have validated a new model to study this pathology
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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