3,845 research outputs found
Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct.
Full text linkVasopressin and vasopressin antagonists are finding expanded use in mouse models of disease and in clinical medicine. To provide further insight into the physiological role of V1a and V2 vasopressin receptors in the human and mouse kidney, intrarenal localization of the receptors mRNA was determined by in situ hybridization. V2-receptor mRNA was predominantly expressed in the medulla, whereas mRNA for V1a receptors predominated in the cortex. The segmental localization of vasopressin-receptor mRNAs was determined using simultaneous in situ hybridization and immunohistochemistry for segment-specific markers, including aquaporin-2, Dolichos biflorus agglutinin, epithelial Na channels, Tamm Horsfall glycoprotein, and thiazide-sensitive Na(+)-Cl(-) cotransporter. Notably, V1a receptor expression was exclusively expressed in V-ATPase/anion exchanger-1-labeled alpha-intercalated cells of the medullary collecting duct in both mouse and human kidney. In cortical collecting ducts, V1a mRNA was more widespread and detected in both principal and intercalated cells. V2-receptor mRNA is diffusely expressed along the collecting ducts in both mouse and human kidney, with higher expression levels in the medulla. These results demonstrate heterogenous axial expression of both V1a and V2 vasopressin receptors along the human and mouse collecting duct. The restricted expression of V1a-receptor mRNA in intercalated cells suggests a role for this receptor in acid-base balance. These findings further suggest distinct regulation of renal transport function by AVP through V1a and V2 receptors in the cortex vs. the medulla
Performances of the HL (Hyperloop) transport system
No full textThis paper deals with an analysis of performances of the HL (Hyperloop) transport system considered as an advanced transport alternative to the existing APT (Air Passenger Transport) and HSR (High Speed Rail) systems. The considered performances are operational, financial, social and environmental. The operational performance include capacity and quality of service provided to the system’s users-passengers with attributes such as door-to-door travel time consisting of the access and egress time, schedule delay, in-vehicle time, and interchange time. The economic performances embrace the costs and revenues of operating the system. The costs include that for infrastructure, vehicles, traffic management facilities and equipment, and employees. The revenues embrace earnings from pricing users/passengers. The environmental performances include energy consumption and related emissions of GHGs (Green House Gases), and land use. The social performances are considered to be noise and safety. The analytical models of indicators of these performances are developed and applied to the scenario of operating the HL system on the short- to medium-haul travel distances/routes. These are then compared to the corresponding performances of the HSR and APT. This comparison has shown that the HL system may possess some advantages but also disadvantages regarding particular performances.Transport and PlanningOLD Urban and Regional Developmen
Letter to David V. Whiting from W. T. H. Brooks
No full textLetter to David V. Whiting, Secretary of the Terrritory of New Mexico from W. T. H. Brooks regarding a reply from Colonel Dunne. Sturgis. Also note about the request to transfer the public buildings in Santa Fe from the United States War Department to the civil authorities of New Mexico on a permanent basis, Brooks would prefer this be better done by those in Washington, D.C. Palace of the Governors, grounds. Document is damaged, in English, 1 pp/fr, missing heading page
Analysis and modelling of performances of the HL (Hyperloop) transport system
No full textIntroduction: Hyperloop (HL) is presented as an efficient alternative of HSR (High Speed Rail) and APT (Air Passenger Transport) systems for long-distance passenger transport. This paper explores the performances of HL and compares these performances to HSR and APT. Methods: The following performances of the HL system are analytically modeled and compared to HSR and APT: (i) operational performance; (ii) financial performance; (iii) social/environmental performance. Results: The main operational result is that the capacity of HL is low which implies a low utilization of the infrastructure. Because the infrastructure costs dominate the total costs, the costs per passenger km are high compared to those for HSR and APT. The HL performs very well regarding the social/environmental aspects because of low energy use, no GHG emissions and hardly any noise. The safety performance needs further consideration. Conclusions: The HL system is promising for relieving the environmental pressure of long-distance travelling, but has disadvantages regarding the operational and financial performances.Transport and PlanningOLD Urban and Regional Developmen
Note to Horace Brooks from Edwin Vose Sumner
No full textNote to Colonel Horace Brooks, United States Army, from Edwin Vose Sumner, Governor and Superintendent of Indian Affairs, Santa Fe, that in his absense he was to give a ration of meat, bread and sugar to any Indians that may arrive during his absence. Document in English, 1 pp/fr, missing heading page
Letter to Horace Brooks from the citizens of Santa Fe
No full textSanta Fe, letter to Horace Brooks, lieutenant Colonel of the United States Army, in Santa Fe, from the citizens of Santa Fe thanking him for the placement of a military unit in the city and for the fine military display on the main plaza. Military to prevent any outbreaks among the native population as in the recent troubles of the Territory, revolts of 1846 - 1847? No signatures. Document in English, 1 pp/fr, missing heading page
How does kinetic friction depend on the contact surface area of a solid?
Full text linkThis essay studies the friction phenomenon to answer the question: “how does kinetic friction depend on the contact surface area of a solid?” The object of research, kinetic friction, has been modified from the sole term “friction” to narrow down the scope of investigation and get accurate results about the factor investigated. Since it is a mechanical subject and it is rather practical to build a setup, an experimental approach is chosen to investigate the topic. The experiment is done in several steps by changing the setup which is a block released from an inclined plane. The angle, distance and mass of the solid is changed for blocks with five different surface areas and the acceleration is measured. Depending on the theoretical correlations between the kinetic friction and the distance, mass and angle of the position of the solid, data for five different surface areas have been obtained.
According to data and graphs, it is seen that, there is no significant relationship between the surface area and the kinetic friction. My hypothesis is concluded to be wrong, however, theoretical works are in coherence with the result of the experiment. Thus, the experiment is done without major errors and the aim is attained
The contribution of social networks to the health and self-management of patients with long-term conditions: a longitudinal study
No full textAim: to determine how the social networks of people with long-term conditions (diabetes and heart disease) are associated with health-related outcomes and changes in outcomes over time.Methods: patients with chronic heart disease (CHD) or diabetes (n = 300) randomly selected from the disease registers of 19 GP practices in the North West of England. Data on personal social networks collected using a postal questionnaire, alongside face-to-face interviewing. Follow-up at 12 months via postal questionnaire using a self-report grid for network members identified at baseline.Analysis: multiple regression analysis of relationships between health status, self-management and health-economics outcomes, and characteristics of patients' social networks.Results: findings indicated that: (1) social involvement with a wider variety of people and groups supports personal self-management and physical and mental well-being; (2) support work undertaken by personal networks expands in accordance with health needs helping people to cope with their condition; (3) network support substitutes for formal care and can produce substantial saving in traditional health service utilisation costs. Health service costs were significantly (p<0.01) reduced for patients receiving greater levels of illness work through their networks.Conclusions: support for self-management which achieves desirable policy outcomes should be construed less as an individualised set of actions and behaviour and more as a social network phenomenon. This study shows the need for a greater focus on harnessing and sustaining the capacity of networks and the importance of social involvement with community groups and resources for producing a more desirable and cost-effective way of supporting long term illness managemen
Studies on the HL--A antigens Distributions among Normal Korean Population and Gastric Cancer Patients
No full textEven though the HL-A antigens as the major
histocompatibility antigens have been contributing
an important role in the immunological aspect of the
clinical transplantation. and recently considerable
attentions are focusing on the possible association
of various disease or malignant disease with the
certain HL-A specifities, any datas for the distribution
of the HL-A antigens in Korean population and
the HL-A serotyping for the kidney transplant is
not available at present time.
This present report is a studies on the HL-A
antigens distribution among 155 normal Korean
population and 76 gastric cancer patients with the
method of Boyum's lymphocyte isolation technic
with Ficoll and Isopaque mixture and the method
of Terasaki's microlymphocytotoxicity test with 29
NIH standard antisera for 16 HL-A specificities at
Seoul National University Hospital.
The results are as following;
1. The HL-A antigens are rather evenly distributed
throughout the first and second series in both normal
Koreans and gastric cancer patient which is a good
evidence of diversity in the polymorphism of HL-A
antigens.
2. The most frequent HL-A antigens are HL-A 2,13.12 and 10 in normal control group. and HL-A
10.5.2 and 13 in gastric cancer patient. HL-A 9 is
rather infrequent compared to other Oriental populations,
and HL-A 1 which has heen recognized to be
absent from Orientals occurs 17.4%.
3. It is interesting findings that in gastric cancer
group HL~A 10 from first sublocus and 5 from second
sublocus are markedly increased than normal control
group and HL-A 11 from first sublocus and 12 from
second sublocus are markedly decreased than normal
control group. The author strongly feels that
. additional study to confirm the above findings
should be done.
4. There is a relatively large proportion of blank
alleles: 24% (first series) and 15% (second series) in
normal control group, and 22% (first series) and
15% (second series) in gastric cancer group, which
seems to be related to the limited number of antisera
and the limited number of serum panels used in this
study, and related to the probable existence of
unknown specifities in OUf native Korean population
Sawtooth-driven neoclassical tearing modes in HL-2A plasmas
No full textNeoclassical tearing modes (NTMs) of m = 2, n = 1 induced by sawtooth crashes in tokamak plasmas are studied based on the results of HL-2A tokamak experiments. A model of sawtooth-driven Delta' for NTMs due to the toroidal coupling effect is proposed and applied to the observed growth of 2/1 islands with the sawtooth oscillation observed in the HL-2A experiment. The neoclassical tearing island growth is calculated based on the model and the result is found to be in good agreement with experimental data.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000312579500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Physics, Fluids & PlasmasPhysics, NuclearSCI(E)EI4ARTICLE12null5
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