173,196 research outputs found
Sensitivity of target cells to immunotoxins: possible role of cell-surface antigens
No full textIn this paper, we describe the activity of conjugates constituted of monoclonal antibodies chemically coupled to ricin and the ricin A-chain-like toxin gelonin. Several antibody-toxin conjugates (immunotoxins) were assayed against a Thy 1.2+ and Lyt 2.2+ T-cell line. Anti-Thy 1.2-gelonin and anti-Lyt 2.2-ricin immunotoxins (IT) had a good cytotoxic activity against target cells, whereas anti-Lyt 2.2-gelonin showed weak or no cytotoxicity. An anti-Lyt 2.2-gelonin IT displayed detectable cytotoxicity only when cells were pretreated with ammonium chloride. IT binding activity was very similar for anti-Thy 1.2 and anti-Lyt 2.2 IT, and surface antigen density was of the same order of magnitude for Thy 1.2 and Lyt 2.2 antigens. Our results suggest that intrinsic properties of the surface target antigen are able to influence the IT cytotoxic efficacy
Jean-François Breton L'Arabie heureuse au temps de la reine de Saba' -VIIe -Ier siècles avant J.-C. (La vie quotidienne)
No full textBron François. Jean-François Breton L'Arabie heureuse au temps de la reine de Saba' -VIIe -Ier siècles avant J.-C. (La vie quotidienne). In: Syria. Tome 77, 2000. p. 336
Jean-François Breton L'Arabie heureuse au temps de la reine de Saba' -VIIe -Ier siècles avant J.-C. (La vie quotidienne)
No full textBron François. Jean-François Breton L'Arabie heureuse au temps de la reine de Saba' -VIIe -Ier siècles avant J.-C. (La vie quotidienne). In: Syria. Tome 77, 2000. p. 336
C. A. De Leeuw. Aelius Aristides als Bron voor de Kennis van zijn Tijd
No full textCrahay Roland. C. A. De Leeuw. Aelius Aristides als Bron voor de Kennis van zijn Tijd. In: L'antiquité classique, Tome 9, fasc. 1, 1940. pp. 131-132
Openness and innovation: an empirical analysis in firms located in the Republic of San Marino
No full textOpening up the innovation process to include collaboration with external partners is an increasingly common practice among
firms. Today, also small and medium-sized firms appear to have understood the usefulness of forming alliances and building
networks in order to compete in the knowledge economy. This paper aims to further investigate the actors, the phases of the
innovation process, the dynamics and the determinants that prompt businesses in a small state such as San Marino, to collaborate
in innovation beyond their company and territorial boundaries. A survey has been conducted among manufacturing companies
operating in San Marino state with direct structured interviews to the company directors or persons in charge of R&D. Very few
empirical analyses have been conducted in literature on this subject, and in general these analyses have not focused on Small and
Medium Enterprises. Moreover, this paper investigated a territorial context (Republic of San Marino) which until now have
never been analyzed in terms of innovation. From an academic point of view, the results fill a gap in the literature investigating
the influence of competitive factors during the innovation process. Regarding the actors, the openness of NDP phases and the
determinants of open innovation our study for the most part confirm the literature. The opening up of certain innovation
activities is generally implemented with the aim of integrating and expanding new knowledge and skills and reducing a
product’s time to market. With regard to the variables that influence the openness of the innovation process, the most important
are time, added service and environmental friendliness. From a management point of view, this paper is especially useful to
company directors and government agencies in activating, supporting and guiding innovation policies
Jean-François Breton et Muhammad 'Abd Al Qàdir BàfaqIh, avec M. 'Amir, R. Audouin, M. BaPafïr, F. Baratte, J. Barrera, M. Kazanski, J. Koltès, Ch. Robin, J.-C. Roux, S. Tassinari, Kh. Az-Zubaydï, Trésors du wādī Dura (République du Yemen), Fouille franco- yèmènite de la nécropole de Hajar am- Dhaybiyya, (Bibliothèque archéologique et historique, tome 141)
No full textBron François. Jean-François Breton et Muhammad 'Abd Al Qàdir BàfaqIh, avec M. 'Amir, R. Audouin, M. BaPafïr, F. Baratte, J. Barrera, M. Kazanski, J. Koltès, Ch. Robin, J.-C. Roux, S. Tassinari, Kh. Az-Zubaydï, Trésors du wādī Dura (République du Yemen), Fouille franco- yèmènite de la nécropole de Hajar am- Dhaybiyya, (Bibliothèque archéologique et historique, tome 141). In: Syria. Tome 72 fascicule 1-2, 1995. pp. 279-281
Blik op de stofwisseling als bron der eigene warmte van platen en dieren
No full textBLIK OP DE STOFWISSELING ALS BRON DER EIGENE WARMTE VAN PLATEN EN DIEREN
Blik op de stofwisseling als bron der eigene warmte van platen en dieren (-
Inscriptions from museums in the region of Dhamār : Qatabanians in Baynūn and the goddess Athirat (ʾṯrtn)
No full textIn this volume in honour of Francesco Bron (as I always called François, affectionately Italianizing his name), I publish two inscriptions from two museums
in the governorate of Dhamār: the Museum of Baynūn and the Regional Museum of Dhamār. The first inscription is Qatabanic — F. Bron contributed greatly to our knowledge of the language and culture of Qatabān with his attentive editions of many Qatabanic texts — and the second is on an incense burner dedicated to the goddess Athirat (F. Bron, too, wrote an article about the goddess)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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