170,019 research outputs found

    Il turismo a Roma tra dinamiche quotidiane, appuntamenti internazionali e grandi eventi

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    Il settore turistico laziale è chiamato ad affrontare la duplice sfida che lo attende dopo la crisi dovuta alla pandemia da Covid 19 e il rimbalzo espansivo c he ne è seguito. L’orizzonte del mercato globale, che riguarda anzitutto i flussi turistici verso Roma ma inizia ad interessare anche altre desti- nazioni regionali, richiede uno sforzo di riorganizzazione del- l’offerta che sappia selezionare e competere sui livelli più alti della domanda. La prospettiva assai promettente di una ro- busta domanda di turismo di prossimità, a sua volta, obbliga l’intero tessuto territoriale regionale ad attrezzarsi in forme integrate di rappresentazione e gestione dell’offerta che rappresentano una straordinaria opportunità di sviluppo per le aree interne e marginali. A tali sfide, il sistema formativo delle competenze adeguate, soggette a una rapidissima spinta di innovazione, deve saper rispondere con flessibilità e tempestività

    Neurological assessment of late-preterm infants during the first year of age.

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    Sars-cov-2 detection in fecal sample from a patient with typical findings of covid-19 pneumonia on ct but negative to multiple sars-cov-2 rt-pcr tests on oropharyngeal and nasopharyngeal swab samples

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    Reverse transcriptase polymerase chain reaction (RT-PCR) negative results in the upper respiratory tract represent a major concern for the clinical management of coronavirus disease 2019 (COVID-19) patients. Herein, we report the case of a 43-years-old man with a strong clinical suspicion of COVID-19, who resulted in being negative to multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR tests performed on different oropharyngeal and nasopharyngeal swabs, despite serology having confirmed the presence of SARS-CoV-2 IgM. The patient underwent a chest computed tomography (CT) that showed typical imaging findings of COVID-19 pneumonia. The presence of viral SARS-CoV-2 was confirmed only by performing a SARS-CoV-2 RT-PCR test on stool. Performing of SARS-CoV-2 RT-PCR test on fecal samples can be a rapid and useful approach to confirm COVID-19 diagnosis in cases where there is an apparent discrepancy between COVID-19 clinical symptoms coupled with chest CT and SARS-CoV-2 RT-PCR tests’ results on samples from the upper respiratory tract

    Uterine Leiomyosarcoma Metastatic to the Brain: Case Report

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    Background We report a leiomyosarcoma of the uterus, an uncommon tumor with a very aggressive course and poor prognosis due to the fact that, despite complete resection, it recurs with micrometastases. The most common metastatic sites are the lung, intraperitoneal, pelvic and paraaortic lymph nodes, and liver. Brain and skull metastases are very rare. Case A 57-year-old woman underwent a hysterectomy and bilateral salpingo-oophorectomy for a grade T2N0M0 uterine leiomyosarcoma. There was no evidence of other lesions. Three months later a total-body PET scan demonstrated the presence of metastases in both lungs, and the patient was started on chemotherapy. One year later a cranial MRI demonstrated a brain metastasis to the temporal lobe. Emergency complete resection of the recurrence was performed, followed by whole-brain radiation and adjuvant chemotherapy. Conclusions Given the limited treatment options, the gold standard for uterine leiomyosarcoma brain metastasis is total surgical removal. Chemotherapy and radiation therapy may provide only palliative benefit. </jats:sec

    Could SARS-CoV-2 Have Bacteriophage Behavior or Induce the Activity of Other Bacteriophages?

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    SARS-CoV-2 has become one of the most studied viruses of the last century. It was assumed that the only possible host for these types of viruses was mammalian eukaryotic cells. Our recent studies show that microorganisms in the human gastrointestinal tract affect the severity of COVID-19 and for the first time provide indications that the virus might replicate in gut bacteria. In order to further support these findings, in the present work, cultures of bacteria from the human microbiome and SARS-CoV-2 were analyzed by electron and fluorescence microscopy. The images presented in this article, in association with the nitrogen (15N) isotope-labeled culture medium experiment, suggest that SARS-CoV-2 could also infect bacteria in the gut microbiota, indicating that SARS-CoV-2 could act as a bacteriophage. Our results add new knowledge to the understanding of the mechanisms of SARS-CoV-2 infection and fill gaps in the study of the interactions between SARS-CoV-2 and non-mammalian cells. These findings could be useful in suggesting specific new pharmacological solutions to support the vaccination campaign

    Cervicothoracic epidural hematoma after chiropractic spinal manipulation therapy. Case report and review of the literature

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    A spinal epidural hematoma is an extremely rare complication of cervical spine manipulation therapy (CSMT). The authors present the case of an adult woman, otherwise in good health, who developed Brown-Séquard syndrome after CSMT. Decompressive surgery performed within 8 hours after the onset of symptoms allowed for complete recovery of the patient's preoperative neurological deficit
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