1,320 research outputs found
Recovery through contradiction?
No full textWith this new drug strategy, the circle has turned. It was a Conservative government
that introduced the first drug strategy, Tackling Drugs Together, in 1995. This aimed
to reduce drug related crime, protect young people and reduce health harms by
discouraging drug use. It was criticised at the time for having unrealistic, intangible
aims and for not providing the necessary funding. New Labour’s strategies introduced
increasingly specific targets and massively expanded the funding of treatment. This
new Coalition strategy has no targets and provides no new funding
105 - Alex M Fout
No full textIncludes bibliographical references.This poster was presented at the 2017 Colorado State University Graduate Student Showcase, 9 November 2017.Determining the interface between two interacting proteins can help illuminate cellular biology, improve our understanding of disease, and aid pharmaceutical research. Such determination is expensive and time consuming using wet-lab experiments, which has motivated the development of computational methods. Inspired by the success of deep learning in image processing and other application areas, we adapt convolutional neural networks to work with irregularly structured data, such as proteins. We construct a novel pairwise classification architecture which is trained and tested with data from the Docking Benchmark Dataset versions 4.0 and 5.0. This outperforms the existing state-of-the-art prediction method, PAIRpred.Graduate Student Council - New Graduate Student - Research Top Scholar
Infrastructure bottlenecks, private provision, and industrial productivity : a study of Indonesian and Thai cities
No full textThis research project followed an earlier similar project on Nigeria, applying the same methods. A sample of manufacturers was surveyed to document their responses to infrastructure deficiencies in electricity, water, transport, telecommunications, and waste disposal. They found the manufacturers undertook significant expenditures to offset deficiencies in publicly provided infrastructure services, and that changing public policy toward privately supplied infrastructure and changing the pricing of public infrastructure could yield significant savings in social costs. Thailand and Indonesia have made significant strides in following the policies for private sector participation in infrastructure provision. Nigeria, where public infrastructure monopolies still dominate, lags behind, yet stands to benefit most from such policy reform. Government policy toward the industrial organization and pricing of infrastructure sectors can significantly help a developing economy realize the benefits of private sector participation in the provision of infrastructure services.Banks&Banking Reform,Decentralization,Public Sector Economics&Finance,Environmental Economics&Policies,Municipal Financial Management,Banks&Banking Reform,Municipal Financial Management,Urban Services to the Poor,Urban Services to the Poor,Public Sector Economics&Finance
Correction to: The ‘can do, do do’ concept in COPD; quadrant interpretation, affiliation and tracking longitudinal changes
No full textFollowing publication of the original article [1], the authors identified a mistake in the author names, as both forename and initials were stated. Initially published author names: A. J. Alex van ’t Hul, E. H. Noortje Koolen, H. W. Jeroen van Hees, B. Bram van den Borst and M. A. Martijn Spruit Correct author names: Alex J. van ‘t Hul, Noortje H. Koolen, Jeroen W. van Hees, Bram van den Borst, Martijn A. Spruit. The original article has been corrected.</p
When the lights go down in Chinatown. / Words by / ALEX GERBER. / Music by / MALIVIN M FRANKLIN.
No full textBox no. 1This item has been bound together with items gma-doc-00525 and gma-doc-00034.Malvin M. Franklin: When the lights go down in Chinatown; music printItem type: book | Content type: music and text | Counting of pages: page numbersVocal-instrumental score | staff notation; tonic sol-fa | voice; piano"Ev'ry evening when the sun goes down [...]
Multi-Objective Calibration For Agent-Based Models
No full textAgent-based modelling is already proving to be an immensely useful tool for scientific and industrial modelling applications. Whilst the building of such models will always be something between an art and a science, once a detailed model has been built, the process of parameter calibration should be performed as precisely as possible. This task is often made difficult by the proliferation of model parameters with non-linear interactions. In addition to this, these models generate a large number of outputs, and their ‘accuracy’ can be measured by many different, often conflicting, criteria. In this paper we demonstrate the use of multi-objective optimisation tools to calibrate just such an agent-based model. We use an agent-based model of a financial market as an exemplar and calibrate the model using a multi-objective genetic algorithm. The technique is automated and requires no explicit weighting of criteria prior to calibration. The final choice of parameter set can be made after calibration with the additional input of the domain expert
Kirchhoff migrated vibroseismic section on Thwaites Glacier, Antarctica from 2023/24
No full textThis vibroseismic survey was conducted on Thwaites Glacier in West Antarctica in 2023/24, as part of the International Thwaites Glacier Collaboration's project GHOST (Geophysical Habitat of Subglacial Thwaites). The 134 km long seismic profile (section 20240551) was measured perpendicular to the flow direction. The recorded raw vibroseismic data were compressed by a cross-correlation with a synthetic source signal. The individual traces were assigned geometry from idealized shot locations and group intervals to organize common midpoint (CMP) gathers. Next, noisy or dead traces were removed. In particular, we removed the eight channels closest to the source as these were generally clipped. A frequency filter from 10–190 Hz was applied to reduce high-frequency noise, and a notch filter at 190 Hz was applied to reduce ringing from the spurious response of the geophones. We performed a zero-phase spike deconvolution to compress the wavelet to a spike. Afterwards, we re-sorted the data into CMP gathers and determined the stacking velocities. Stacking velocities were analysed using an automated constant velocity stacking method. We tested numerous NMO corrections for a broad range of velocities spanning from 3000 to 5000 m/s with 10 m/s intervals. We divided the TWT into segments of 20 ms with 10 ms overlap. For each segment, we identified the optimal stacking velocity based on the stack with the highest amplitude. Next, we estimated the stacking velocities of the ice base, of the base of geological features beneath the ice and of the bed. The stacking velocity at the ice base was calculated from the average of three TWT segments encompassing the ice base. A similar procedure was applied for the geological features. To determine the stacking velocity of the bed, we averaged the velocities of five TWT segments situated approximately 250 ms beneath the ice base or beneath geological features, respectively. For ice and bed, we averaged the stacking velocities over a wide range of 500 CMP gathers and for geological features over 50 CMP gathers. The resulting velocity field was used to perform the normal moveout (NMO) correction. We stacked the NMO-corrected CMP gathers to improve the signal-to-noise ratio. To remove diffraction hyperbolas, we migrated the stacked section with a time-space Kirchhoff migration using interval velocities of ice, geological features and the bed. We estimated the interval velocity of ice to be 3770±35 m/s from an alignment of the ice thickness with airborne radar-derived ice thicknesses. The interval velocities of geological features were determined based on the Dix-Dürbaum-Krey equation using the stacking velocities. We estimated the interval velocity for the transparent features to be 1960±420 m/s. We assumed a constant interval velocity of the bed of 4000 m/s. Finally, we applied a two-way traveltime (TWT) to depth conversion with these interval velocities. This dataset contains the Kirchhoff migrated section in standard SEG-Y format. The individual traces were assigned idealized geometry of CMP locations. The CMP coordinates, bed elevation, ice thickness, and basal slope are given in the .csv file
Development of the Zimbabwe family planning program
No full textFamily planning was introduced in Zimbabwe as a voluntary movement in the 1950s. Volunteers formed a Family Planning Association in the mid-1960s. The government became interested in family planning in the late 1960s after analysis of the 1961 population census. It gave the Family Planning Association an annual grant, allowed contraceptives to be available through Ministry of Health facilities, and allowed nonmedical personnel to initiate and resupply family planning clients with condoms and pills. But before Zimbabwe achieved independence in 1980, family planning was viewed with great suspicion by the black majority, so the program's effectiveness was limited to the urban few. A new era began after independence. The new government took over theFamily Planning Association and changed its outlook completely. Through government and international donor support, the family planning program was restructured and expanded. The number of family planning personnel more than doubled in some units. More service delivery points were set up - particularly in rural areas. And the information, education, and communication and evaluation and research units were established. Through a World Bank-assisted project (with grant funding from Norway and Denmark), the Ministry of Health began strengthening its family planning capabilities. These efforts helped increase the contraceptive prevalence rate from about 14 percent in 1982 to 43 percent in 1988. But the program's growth is beginning to stall. More effort and resources are needed if the program is to grow or even maintain its present status. Particularly important are the following: designing innovative strategies to reach hard-to-reach populations; giving more emphasis to information, education, and communication, especially for men and youths, using multimedia; involving other sectors in the delivery of family planning services; broadening the mix of contraceptive methods (especially promoting long-term and permanent methods); making use of alternative family planning delivery systems, such as the use of depot holders, volunteers, and government extension workers; establishing a national population policy; and considering cost recovery and other measures for self-sustainment and program growth.Agricultural Knowledge&Information Systems,ICT Policy and Strategies,Gender and Health,Health Monitoring&Evaluation,Adolescent Health
Kirchhoff migrated vibroseismic section on Thwaites Glacier, Antarctica from 2022/23
No full textThis vibroseismic survey was conducted on Thwaites Glacier in West Antarctica in 2022/23, as part of the International Thwaites Glacier Collaboration's project GHOST (Geophysical Habitat of Subglacial Thwaites). The 210 km long seismic profile was measured parallel to the average flow direction. The processing of the recorded vibroseismic data to produce a Kirchhoff migrated section involves several standard steps outlined below. The recorded raw vibroseismic data were compressed by a cross-correlation with a synthetic source signal. The individual traces were assigned geometry from idealized shot locations and group intervals to organize common midpoint (CMP) gathers. Next, noisy or dead traces were removed. In particular, we removed the eight channels closest to the source as these were generally clipped. A frequency filter from 10–190 Hz was applied to reduce high-frequency noise, and a notch filter at 190 Hz was applied to reduce ringing from the spurious response of the geophones. We performed a zero-phase spike deconvolution to compress the wavelet to a spike. Afterwards, we re-sorted the data into CMP gathers and determined the stacking velocities. Stacking velocities were analysed using an automated constant velocity stacking method. We tested numerous NMO corrections for a broad range of velocities spanning from 3000 to 5000 m/s with 10 m/s intervals. We divided the TWT into segments of 20 ms with 10 ms overlap. For each segment, we identified the optimal stacking velocity based on the stack with the highest amplitude. Next, we estimated the stacking velocities of the ice base, of the base of geological features beneath the ice and of the bed. The stacking velocity at the ice base was calculated from the average of three TWT segments encompassing the ice base. A similar procedure was applied for the geological features. To determine the stacking velocity of the bed, we averaged the velocities of five TWT segments situated approximately 250 ms beneath the ice base or beneath geological features, respectively. For ice and bed, we averaged the stacking velocities over a wide range of 500 CMP gathers and for geological features over 50 CMP gathers. The resulting velocity field was used to perform the normal moveout (NMO) correction. We stacked the NMO-corrected CMP gathers to improve the signal-to-noise ratio. To remove diffraction hyperbolas, we migrated the stacked section with a time-space Kirchhoff migration using interval velocities of ice, geological features and the bed. We estimated the interval velocity of ice to be 3770±35 m/s from an alignment of the ice thickness with airborne radar-derived ice thicknesses. The interval velocities of geological features were determined based on the Dix-Dürbaum-Krey equation using the stacking velocities. We estimated the interval velocity for a large sedimentary basin to be 2680±440 m/s. We assumed a constant interval velocity of the bed of 4000 m/s. Finally, we applied a two-way traveltime (TWT) to depth conversion with these interval velocities. This dataset contains the Kirchhoff migrated section in standard SEG-Y format. The individual traces were assigned idealized geometry of CMP locations. The CMP coordinates, bed elevation, ice thickness, and basal slope are given in the .csv file
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