240 research outputs found
Memoiren. [Fragment] /
No full textAltmann tells the story of the Jewish community in Nikolsburg starting in 1370. He focuses specifically on the history of the Altmann family, especially Siegfried Altmann's grandparents. The second part of the manuscript deals with stories of Rabbi Mordechai Benet (1753-1829) as told to the author by his grand-aunt.See also archival collection.Altmann was born in Nikolsburg (Maehren) in 1887 and died in 1963 in New York. He was the director of the Institute for the Blind "Hohe Warte" in Vienna.see archival collection AR 1788Benet, MordechaiWalter, BrunoNikolsburg (Moravia)digitize
Fashion Culture: Fashion Metropolis Berlin
No full textBerlin was a fashion capital in the 1920s, with hundreds of thriving clothing manufacturers, most of them Jewish, before it was decimated by the Nazis. Author Uwe Westphal shares this history in a discussion with FIT historian Keren Ben-Horin and journalist Jennifer Altmann, whose grandfather ran one of Berlin’s fashion houses.Organized in partnership with the Museum at Eldridge Street
Controlling osteoblastmorphology and proliferation via surface micro-topographies of implant biomaterials
No full textCurrent research on surface modifications has yielded advanced implant biomaterials. Various implant surface modifications have been shown to be promising in improving bone target cell response, but more comprehensive studies whether certain implant surface modifications can directly target cell behavioural features such as morphogenesis and proliferation are needed. Here, we studied the response of primary alveolar bone cells on various implant surface modifications in terms of osteoblast morphology and proliferation in vitro. Analyses of surface modifications led to surface-related test parameters including the topographical parameters micro-roughness, texture aspect and surface enlargement as well as the physicochemical parameter surface wettability. We compared osteoblast morphology and proliferation towards the above-mentioned parameters and found that texture aspect and surface enlargement but not surface roughness or wettability exhibited significant impact on osteoblast morphology and proliferation. Detailed analysis revealed osteoblast proliferation as a function of cell morphology, substantiated by an osteoblast size- and morphology-dependent increase in mitotic activity. These findings show that implant surface topography controls cell behavioural morphology and subsequently cell proliferation, thereby opening the road for cell instructive biomaterials
Economics in Persian-period biblical texts : their interactions with economic developments in the Persian period and earlier biblical traditions
No full textLarge-scale economic change such as the rise of coinage occurred during the Persian-dominated centuries (6th –4th centuries BCE) in the Eastern Mediterranean and ancient Near East. How do the biblical texts of the time respond to such developments?
In this study, Peter Altmann lays out foundational economic conceptions from the ancient Near East and earlier biblical traditions in order to show how Persian-period biblical texts build on these traditions to address the challenges of their day. Economic issues are central to the way that Ezra and Nehemiah approach the topics of temple building and of Judean self-understanding. Economic terminology and considerations also appear in Second Isaiah and the “Holiness Code.” Following significant interaction with the material culture and extra-biblical texts, the author devotes special attention to the ascendancy of economics and its theological and identity implications as structuring metaphors for divine action and human community in the Persian period.
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Dynamic release kinetics and biological impact of leachables from 3d-printed oral devices: an integrated in vitro and computational exposure model
No full textResearch has highlighted the release of monomers and leachables from additively manufactured (AM) oral devices, raising concerns about their potential biological impact. The oral cavity's dynamic epithelial system necessitates exposure models that accurately reflect real-world conditions. Traditional static models often overestimate or underestimate patient exposure, failing to predict in vivo risks effectively. To address this gap, we developed an advanced dynamic oral tissue exposure model that simulates the release kinetics of leachables, saliva flow, and gingival tissue perfusion. This dynamic approach, integrated with an in vitro human gingival keratinocyte (HGK) model, was applied for the first time in this study. We quantified urethane dimethacrylate (UDMA) release from AM biomaterials through extraction experiments, generating data for computational modeling. The model revealed that dynamic in vivo monomer exposure peaks at specific time points before declining, a pattern not captured by static calculations. In vitro analysis showed that UDMA exposure inhibited metabolic activity and reduced Ki-67 expression in HGK cultures at micromolar concentrations. While inhibitory in vitro concentrations exceeded predicted in vivo estimates, low-dose effects on Ki-67 expression were still observed. These findings suggest that although calculated UDMA exposure remains sub-cytotoxic, it may still induce sensitizing effects. Overall, the dynamic exposure model introduced in this study represents a significant advancement in risk assessment, offering more accurate predictions of the biological effects of leachables and contributing to the safety evaluation of AM biomaterials.Statement of significanceAdditively manufactured (AM) oral devices are a significant source of monomer release into the oral cavity, raising concerns about tissue exposure. Traditional static models provide limited or inaccurate risk estimates due to the cavity’s dynamic nature. In this study, we developed a dynamic oral tissue exposure model that estimates in vivo-relevant monomer and leachable concentrations in saliva and oral mucosa while integrating an in vitro gingival keratinocyte model to assess biological effects. The model provides key insights into predicted in vivo exposure to monomers and leachables, improving in vitro evaluations of biological effects. Overall, it serves as a valuable risk assessment tool for the research community by enhancing predictions of patient exposure to potential monomers and leachables, thereby supporting AM biomaterial safety
Reinhard Köhler's Scientific Production: Words, Numbers and Pictures, di Arjuna Tuzzi
No full textThis study draws upon statistical analysis techniques of textual data to examine a corpus composed of 22 research articles published between 1997 and 2010 by Reinhard Köhler as a single author or in collaboration with other scholars. The aim of this article is to draw a representation of the main areas of interest of his research. After having drawn an overall representation of the corpus, Köhler’s latest work – an unpublished volume on Quantitative Syntax Analysis – was analysed to understand its role within the context of his research
Assessment of Novel Long-Lasting Ceria-Stabilized Zirconia-Based Ceramics with Different Surface Topographies as Implant Materials
No full textThe development of long-lasting zirconia-based ceramics for implants, which are not prone to hydrothermal aging, is not satisfactorily solved. Therefore, this study is conceived as an overall evaluation screening of novel ceria-stabilized zirconia–alumina–aluminate composite ceramics (ZA8Sr8-Ce11) with different surface topographies for use in clinical applications. Ceria-stabilized zirconia is chosen as the matrix for the composite material, due to its lower susceptibility to aging than yttria-stabilized zirconia (3Y-TZP). This assessment is carried out on three preclinical investigation levels, indicating an overall biocompatibility of ceria-stabilized zirconia-based ceramics, both in vitro and in vivo. Long-term attachment and mineralized extracellular matrix (ECM) deposition of primary osteoblasts are the most distinct on porous ZA8Sr8-Ce11p surfaces, while ECM attachment on 3Y-TZP and ZA8Sr8-Ce11 with compact surface texture is poor. In this regard, the animal study confirms the porous ZA8Sr8-Ce11p to be the most favorable material, showing the highest bone-to-implant contact values and implant stability post implantation in comparison with control groups. Moreover, the microbiological evaluation reveals no favoritism of biofilm formation on the porous ZA8Sr8-Ce11p when compared to a smooth control surface. Hence, together with the in vitro in vivo assessment analogy, the promising clinical potential of this novel ZA8Sr8-Ce11 as an implant material is demonstrated
The lipidome and proteome of microsomes from the methylotrophic yeast Pichia pastoris
No full textThe methylotrophic yeast Pichia pastoris is a popular yeast expression system for the production of heterologous proteins in biotechnology. Interestingly, cell organelles which play an important role in this process have so far been insufficiently investigated. For this reason, we started a systematic approach to isolate and characterize organelles from P. pastoris. In this study, we present a procedure to isolate microsomal membranes at high purity. These samples represent endoplasmic reticulum (ER) fractions which were subjected to molecular analysis of lipids and proteins. Organelle lipidomics included a detailed analysis of glycerophospholipids, fatty acids, sterols and sphingolipids. The microsomal proteome analyzed by mass spectrometry identified typical proteins of the ER known from other cell types, especially Saccharomyces cerevisiae, but also a number of unassigned gene products. The lipidome and proteome analysis of P. pastoris microsomes are prerequisite for a better understanding of functions of this organelle and for modifying this compartment for biotechnological applications. (C) 2013 Elsevier B.V. All rights reserved
Präklinische in vitro Evaluierung von neuen Zirkon-basierten Nanokompositen und deren Oberflächenstrukturen für die Entwicklung von Implantaten. DGBM Jahrestagung, Freiburg, Deutschland,
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