1,921 research outputs found
Children's folklore: a source book
No full textEdited by Brian Sutton-Smith, Jay Mechling, Thomas W. Johnson, Felicia R. McMahon.Includes bibliographical references and index.A collection of original essays by scholars from a variety of fields--including American studies, folklore, anthropology, psychology, sociology, and education--Children's Folklore: A Source Book moves beyond traditional social-science views of child development. It reveals the complexity and artistry of interactions among children, challenging stereotypes of simple childhood innocence and conventional explanations of development that privilege sober and sensible adult outcomes. Instead, the play and lore of children is shown to be often disruptive, wayward, and irrational. The contributors variably consider and demonstrate contextual and "textual" ways of studying the folklore of children. Avoiding a narrow definition of the subject, they examine a variety of resources and approaches for studying, researching, and teaching it. These range from surveys of the history and literature of children's folklore to methods of field research, studies of genres of lore, and attempts to capture children's play and games".--Provided by publisher.Introduction: What Is Children's Folklore? / Brian Sutton-Smith -- Who Are the Folklorists of Childhood? / Sylvia Ann Grider -- Overview: History of Children's Folklore / Brian Sutton-Smith -- The Complexity of Children's Folklore / Rosemary Levy Zumwalt -- The Transmission of Children's Folklore / John H. McDowell -- Overview: Methods in Children's Folklore / Brian Sutton-Smith -- Double Dutch and Double Cameras: Studying the Transmission of Culture in an Urban School Yard / Ann Richman Beresin -- Children's Games and Gaming / Linda A. Hughes -- Methodological Problems of Collecting Folklore from Children / Gary Alan Fine -- Overview: Children's Folklore Concerns / Brian Sutton-Smith -- Songs, Poems, and Rhymes / C.W. Sullivan III -- Riddles / Danielle M. Roemer -- Tales and Legends / Elizabeth Tucker -- Teases and Pranks / Marilyn Jorgensen -- Overview: Settings and Activities / Brian Sutton-Smith -- Children's Lore in School and Playgrounds / Bernard Mergen -- Material Folk Culture of Children / Simon J. Bronner -- Children's Folklore in Residential Institutions: Summer Camps, Boarding Schools, Hospitals, and Custodial Facilities / Jay Mechling -- Conclusion: The Past in the Present: Theoretical Directions for Children's Folklore / Felicia R. McMahon, Brian Sutton-Smith -- Bibliography of Children's Folklore / Thomas W. Johnson, Felicia R. McMahon
Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen
No full textThe monoclonal IgM cold agglutinins that bind to the I/i carbohydrate Ags on the surface of RBCs all have Ig H chains encoded by the V4-34 gene segment. This mandatory use indicates that distinctive amino acid sequences may be involved in recognition. Critical amino acids exist in framework region 1 (FR1) of V4-34-encoded Ig, and these generate a specific Id determinant which apparently lies close to the I binding site. However, I binding by Id-expressing Ig can be modulated by sequences in complementarity-determining region (CDR)H3. Examination of the crystal structure of an anti-I cold agglutinin has revealed a hydrophobic patch in FR1 involving residue W7 on {beta}-strand A and the AVY motif (residues 23–25) on {beta}-strand B. In this study we used mutagenesis to show that each of the strand components of the hydrophobic patch is required for binding the I carbohydrate Ag. In addition, the crystal structure reveals that amino acids in the carboxyl-terminal region of CDRH3 form a surface region adjacent to the hydrophobic patch. We propose that the I carbohydrate Ag interacts simultaneously with the entire hydrophobic patch in FR1 and with the outside surface of CDRH3. This interaction could leave most of the conventional binding site available for binding other Ags.<br/
2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope
No full textAbstract not availableRobert S. Sheldon, Blair P. Grubb II, Brian Olshansky, Win-Kuang Shen, Hugh Calkins, Michele Brignole, Satish R. Raj, Andrew D. Krahn, Carlos A. Morillo, Julian M. Stewart, Richard Sutton, Paola Sandroni, Karen J. Friday, Denise Tessariol Hachul, Mitchell I. Cohen, Dennis H. Lau, Kenneth A. Mayuga, Jeffrey P. Moak, Roopinder K. Sandhu, Khalil Kanjwa
The structure of PghL hydrolase bound to its substrate poly-γ-glutamate
No full textThe identification of new strategies to fight bacterial infections in view of the spread of multiple resistance to antibiotics has become mandatory. It has been demonstrated that several bacteria develop poly-?-glutamic acid (?-PGA) capsules as a protection from external insults and/or host defence systems. Among the pathogens that shield themselves in these capsules are Bacillus anthracis, Francisella tularensis and several Staphylococcus strains. These are important pathogens with a profound influence on human health. The recently characterised ?-PGA hydrolases, which can dismantle the ?-PGA-capsules, are an attractive new direction that can offer real hope for the development of alternatives to antibiotics, particularly in cases of multidrug resistant bacteria. We have characterised in detail the cleaving mechanism and stereospecificity of the enzyme PghL (previously named YndL) from Bacillus subtilis encoded by a gene of phagic origin and dramatically efficient in degrading the long polymeric chains of ?-PGA. We used X-ray crystallography to solve the three-dimensional structures of the enzyme in its zinc-free, zinc-bound and complexed forms. The protein crystallised with a ?-PGA hexapeptide substrate and thus reveals details of the interaction which could explain the stereospecificity observed and give hints on the catalytic mechanism of this class of hydrolytic enzymes
On morphology, molecular composition and breakdown behaviour in semi-crystalline polymers
No full textFIGURES 77–84 in New species and host plants of Anastrepha (Diptera: Tephritidae) primarily from Suriname and Pará, Brazil
No full textFIGURES 77–84. Eversible membranes, dorsal unless otherwise indicated: 77–78, A. crassaculeus (Colombia: Pamplonita, ICAMF00000437; Suriname: Brownsberg, USNMENT00875105); 79–80, A. curvivenis (Brazil: Rio Urucu, USN- MENT01526558; 80, lateral); 81, A. curvivenis (Peru: Tarapoto, USNMENT00744647); 82–83, A. fuscoalata (Suriname: Berg en Dal, USNMENT01526233; 83, dorsoapical); 84, A. gangadini (Suriname: Brownsberg, USNMENT00875038).Published as part of Norrbom, Allen L., Muller, Alies, Gangadin, Anielkoemar, Sutton, Bruce D., Rodriguez, Erick J., Savaris, Marcoandre, Lampert, Silvana, Rodriguez, Pedro A., Steck, Gary J., Moore, Matthew R., Nolazco, Norma, Troya, Henry, Keil, Clifford B., Padilla, Anabel, Wiegmann, Brian M., Cassel, Brian, Branham, Marc & Ruiz-Arce, Raul, 2021, New species and host plants of Anastrepha (Diptera: Tephritidae) primarily from Suriname and Pará, Brazil, pp. 1-74 in Zootaxa 5044 (1) on page 63, DOI: 10.11646/zootaxa.5044.1.1, http://zenodo.org/record/553202
Preclinical evaluation of the effect of the combined use of the Ethicon Securestrap® Open Absorbable Strap Fixation Device and Ethicon Physiomesh™ Open Flexible Composite Mesh Device on surgeon stress during ventral hernia repair [Corrigendum]
No full textSutton N, MacDonald MH, Lombard J, et al. [Med Devices (Auckl)]. 2018;11:1–9. On page 1, the co-author’s name was incorrectly listed as Bodgan Ilie. His correct name should be Bogdan Ilie. Read the original articl
Limiting Avoidable Microbiological Variability
No full text[ "Microbiology Topics" discusses various topics in microbiology of practical use in validation and compliance. We intend this column to be a useful resource for daily work applications. Reader comments, questions, and suggestions are needed to help us fulfill our objective for this column. Case studies from readers are most welcome. Please send your comments and suggestions to column coordinator Scott Sutton at scott.sutton@microbiol. org or journal coordinating editor Susan Haigney at [email protected]. KEY POINTS The following key points are discussed in this article: • Quality control (QC) microbiology test data are subject to significant variability, both avoidable and unavoidable • Good microbiological procedures, backed by sound microbiological practices, can serve to minimize avoidable variability • The lab's standard operating procedure (SOP) system is a powerful tool to describe and document compliance with good practice • The lab should determine critical areas of coverage for the SOP system to ensure a comprehensive program • The SOP for a lab test should describe critical parameters of the test and meet the criteria of regulatory requirements and guidance for that procedure. The documentation of compliance with these requirements is both a legitimate good manufacturing practice (GMP) audit concern and a useful source of information for investigations. • A sound SOP system can serve to minimize avoidable variability in the microbiology lab • SOPs may be categorized into testing methods, documentation and SOPs, environmental monitoring, and laboratory support activities • Training for the members of the lab should be tightly tied to the SOP system, and can support functional specialization of staff • SOPs for each functional area are described • The content of this discussion should serve to benchmark your system, guide regulatory compliance, and be a framework for training • Considering the SOP system from a functional perspective links job skills to SOPs and facilitates tracking of revisions • Controlling variability and avoidable error is critical to successful microbiology laboratory operation because microbiology is exquisitely sensitive to personnel performance and techniques. INTRODUCTION Microbiology in the QC laboratory is subject to variability in the test results, in the samples taken, in the manner in which they are taken (with severe limitations in sample size contributing to the problem), and Limiting Avoidable Microbiological Variability Scott Sutton ABOUT THE AUTHOR Scott Sutton, Ph.D., is owner and operator of The Microbiology Network (www.microbiol.org), which provides services to microbiology-related user's groups. Dr. Sutton can be reached at scott. [email protected]. g x p a n d j v t . c o
Social-ecological analysis of climate induced changes in biodiversity – outline of a research concept
No full textThe interactions of changes in climate and biodiversity with societal actions, structures and processes are a priority topic within the international scientific debate – and thus, a relevant subject matter for BiKF’s work. This paper outlines a concept for transdisciplinary research within BiKF. It focuses on the analysis of social-ecological systems supporting society with biodiversity driven ecosystem services. Such research is considering different issues: defining sustainable societal adaptations to climate induced biodiversity changes; permitting adequate understanding of the social-ecological reproduction of ecosystem functions, including their conservation and restoration; analysing the societal values and socio-economic utilisation of ecosystem services. Gaining knowledge in these areas provides an improved basis for decision-making in biodiversity and resource management
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