425 research outputs found
BUDGET PERSPECTIVES 2007
No full text1. DISABILITY BENEFIT – CONTROLLED OR UNDER-CONTROLLED?
Brenda Gannon p. 3
2. CHILD POVERTY AND CHILD INCOME SUPPORTS: IRELAND IN COMPARATIVE PERSPECTIVE
Tim Callan, Kieran Coleman, Brian Nolan and John Walsh p. 23
3. STATE FINANCIAL SUPPORT FOR HORSE RACING IN IRELAND
Tony Fahey and Liam Delaney p. 3
DS_10.1177_0363546519852622 – Supplemental material for Subsequent Injury Risk Is Elevated Above Baseline After Return to Play: A 5-Year Prospective Study in Elite Australian Football
No full textSupplemental material, DS_10.1177_0363546519852622 for Subsequent Injury Risk Is Elevated Above Baseline After Return to Play: A 5-Year Prospective Study in Elite Australian Football by Jordan J. Stares, Brian Dawson, Peter Peeling, Jarryd Heasman, Brent Rogalski, Jack Fahey-Gilmour, Gregory Dupont, Michael K. Drew, Marijke Welvaert and Liam Toohey in The American Journal of Sports Medicine</p
Reforming the City through, by or in spite of Law? Exploring Legal and Anthropological Perspectives on Banking and Finance
No full textDuring a public event hosted by the City Law School (City University of London) on Thursday 25 February 2016, Dr Castellano discussed the relationship between regulation and financial markets in the aftermath of the Global Financial Crisis with Joris Luyendijk (author, anthropologist and journalist with The Guardian), Brett Scott (author, anthropologist), and Elaine Fahey (City Law School)
Carsey Perspectives: Children in United States, Both White and Black, Are Growing Up in Dramatically Smaller Families
No full textIn this perspectives brief, author Tony Fahey presents novel findings on how much smaller family sizes are among children in the United States today, particularly African American children, than they were fifty years ago. Using data from the Integrated Public Use Microdata Series from the U.S. Census and the Current Population Survey, he reports that the average African American child was one of 6.53 siblings in 1960 and today is one of 3.18. Because smaller families may enable parents to devote more resources to each child, these trends raise the so-far unrecognized possibility that the fall in children’s family size, especially among the less well-off, may have been a positive and egalitarian transformation in their lives. The trend toward smaller families potentially offsets some of the negative effects on children of the transition from two-parent families to single-parent families. The loss of family resources caused by the absence of one parent is paired with a smaller number of siblings who need support. To better understand how family change has affected children’s well-being, the hidden story of children’s family size and how it relates to other aspects of children\u27s changing family circumstances needs to be recognized and explore
Housing Expenditures, Housing Poverty and Housing Wealth: Irish Home Owners Brian Nolan In Comparative Context
No full textInjection of botulinum toxin for treatment of chronic lateral epicondylitis: systematic review and meta-analysis
No full textObjectives: lateral epicondylitis can be chronic and difficult to manage with conservative measures such as physical therapy and corticosteroid injection. We attempted to determine the efficacy of botulinumtoxin for the treatment of chroniclateral epicondylitis.Methods: we searched PubMed, MEDLINE, CINAHL, Google Scholar, EMBASE, PEDro, and ISI web of Science databases from inception until November 2009. Studies were included if they used any formulation of botulinumtoxin A for treatment of chroniclateral epicondylitis and reported at least 1 pain outcome. One author extracted the relevant data using a standardized data extraction sheet and a second author checked the data. We performed a meta-analysis by computing effect sizes for each study separately for pain and grip strength at 3 months after injection. Impact of bias was assessed independently by 2 authors.Results: the search found 10 studies relevant to the question. Four of these were randomized controlled trials that could be pooled in a meta-analysis. Results showed a moderate effect for pain favoring botulinumtoxin (effect size ?0.5, 95% CI ?0.9, ?0.1, I2 = 56%) at 3 months and a no effect for grip strength. Qualitative analysis of the studies that could not be pooled also showed improvement in pain, but was limited by potential bias.Conclusions: present literature provides support for use of botulinumtoxin A injections into the forearm extensor muscles (60 units) for treatment of chronictreatment-resistant lateral epicondylitis. It is minimally invasive and can be performed in an outpatient settin
Crown Architecture and Xylem-Borne Sucrose Production in Stand-grown Sugar Maple (Acer saccharum Marsh.) of the Adirondack Mountains.
No full textThe concept of the ideotype is applied to trees grown for maple syrup production. While leaf area had been hypothesized as the controlling parameter it had not been actually measured, nor had individual tree yield been assessed on a per hectare basis.
Based on the hypothesis that leaf area and sap and sugar yield are causally related, a basic reassessment was conducted of both crown architecture and the temporal and spatial variation of xylem-borne sucrose production. Destructive sampling was conducted to measure above-ground allometry in 18 trees up to 43.5 cm dbh. Between 1981 and 1989, up to 86 trees were sampled for xylem sugar following several sap runs each year; of these trees, seven were open-grown and five were harvested at varying heights.
While crown volume was the best variable for predicting leaf area, it was not as effective as projected crown area or dbh in accounting for variation in sap and sugar yields among trees. Open-grown trees produced the largest amounts of sap and sugar, but when viewed on a per hectare basis, their yield was almost half of the maximum for stand-grown trees. Percent sap sugar was significantly higher with increasing tap height, and while sap volume flow was greatly reduced, it did occur throughout the sap season, and without vacuum extraction, from single taps 14 m aboveground. Within year, the maximum recorded percent sap sugar appeared to coincide with the date at which the regression of the mean daily temperature rises above 0 oC.
Variation among years is clearly the largest source of variance in sap and sugar yield; however, previous defoliation studies indicate that xylem sugar and starch accumulation or photosynthetic capacity is not coupled. Research reported here supports this conclusion by showing a poor correlation of leaf area to percent sugar. Xylem embolization driven by leafless stem transpiration could be affecting sap yields and sugar concentration not only within the crown but also at breast height among different trees. Wintertime evaporative demand could, therefore, be more important than summertime photosynthesis in determining sap and sugar yield within and among seasons
The impact of Account Management on the motivation and performance of a sales team in an Irish insurance company
No full textThis study aims to discover the impact of outcome based sales force control systems on the motivation and performance of sales people. Businesses strive for service efficiency, a customer relationship focus and most importantly growth in income. The case study focuses on one example of a control system used to meet these objectives in the form of account management introduced into the direct sales force of an Irish insurance company. It is also a means to performance manage employees and manage by objectives. But, there is a lack of empirical evidence to show how successful account management is in this context and its impact on employees’ motivation to achieve those objectives which this study provides.
A quantitative research method is used to answer the research question by surveying a sample of the sales force using an online questionnaire. The data is analysed using descriptive and inferential statistics to summarise the findings.
The study finds that goals set for employees within account management satisfy the 5 key principles of goal setting and are motivating factors. Goals were also found to be specific, measureable, achievable, realistic and timely (SMART). Intrinsic motivators that have a greater effect on sales people were evident with one exception being the lack of personal recognition. The characteristics of job designs that positively influence psychological states were also satisfied by account management. Goals were found to be closer aligned to company objectives and employees believed that account management had a positive effect on their own and the company’s performance.
The study concludes that employee motivation to achieve objectives and performance is enhanced by the introduction of account management and poses a further related research question by asking if goals are too challenging, difficult or complex do these goals then become demotivating factors
The Effect of Cancer-Associated SETD2 Mutations on Transcription and Chromatin Organization
No full textClear cell renal cell carcinoma is characterized by mutations in chromatin modifying enzymes. Among these is SETD2, a non-redundant histone H3 lysine 36 methyltransferase. Mutations in SETD2 in ccRCC are either early-inactivating, occur in the catalytic SET domain, or are found in the Set2 Rpb1-interacting domain. We inactivated SETD2 in ccRCC cells lines and reintroduced a truncated but functional wildtype SETD2 (tSETD2), as well as three ccRCC-associated point mutations in order to examine the effect on DNA damage repair, chromatin organization, transcription, and H3K36 trimethylation. We found that SETD2 loss results in complete loss of H3K36me3. SETD2Δ cells do not resolve γH2A.X foci after DNA damage and show altered chromatin accessibility. Transcription is largely unaffected by SETD2 loss. tSETD2 restores H3K36me3 to loci marked by H3K36me3 in wildtype cells, indicating that the N-terminus of SETD2 in not required for H3K36me3 placement. The first examined point mutant, R1625C, occurs in the SET domain and disrupts catalytic activity of SETD2 by reducing the interaction between SETD2 and histone H3, which results in decreased protein stability in the cell. The second examined point mutation, R2510H, occurs in the SRI domain. This SRI domain mutant is catalytically active. The third mutation, T2457*, deletes the SRI domain from tSETD2, and is also catalytically active. Both the R2510H and the T2457* mutations disrupt the interaction between SETD2 and RNA polymerase II. Surprisingly, both of these mutants also restore H3K36me3 to loci marked by wildtype SETD2. These mutants also show increased H3K36me3 levels near the TSS relative to wildtype. This suggests that the SRI domain is necessary for interaction with RNAPII, is not required for normal H3K36me3 placement across the genome, and may be involved at the TSS for H3K36me3 marking. The separation of function for the SET and SRI domains is of important consideration when developing therapeutics which target SETD2 mutation in ccRCC.Doctor of Philosoph
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